FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033713750> ?p ?o ?g. }

• W2033713750 endingPage "4841" @default.
• W2033713750 startingPage "4836" @default.
• W2033713750 abstract "We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength.The objective of this study was to quantify changes in muscle protein kinetics, body composition, and strength during a clinical bed rest model reflecting both physical inactivity and the hormonal stress response to injury or illness.Muscle protein kinetics were calculated during a primed, continuous infusion (0.08 micromol/kg.min) of 13C6-phenylalanine on d 1 and 28 of bed rest.The setting for this study was the General Clinical Research Center at the University of Texas Medical Branch.Participants were healthy male volunteers (n = 6, 28 +/- 2 yr, 84 +/- 4 kg, 178 +/- 3 cm).During bed rest, hydrocortisone sodium succinate was administered iv (d 1 and 28) and orally (d 2-27) to reproduce plasma cortisol concentrations consistent with trauma or illness (approximately 22 microg/dl).We hypothesized that inactivity and hypercortisolemia would reduce lean muscle mass, leg extension strength, and muscle protein synthesis.Volunteers experienced a 28.4 +/- 4.4% loss of leg extension strength (P = 0.012) and a 3-fold greater loss of lean leg mass (1.4 +/- 0.1 kg) (P = 0.004) compared with our previous bed rest-only model. Net protein catabolism was primarily due to a reduction in muscle protein synthesis [fractional synthesis rate, 0.081 +/- 0.004 (d 1) vs. 0.054 +/- 0.007%/h (d 28); P = 0.023]. There was no change in muscle protein breakdown.Prolonged inactivity and hypercortisolemia represents a persistent catabolic stimulus that exacerbates strength and lean muscle loss via a chronic reduction in muscle protein synthesis." @default.
• W2033713750 created "2016-06-24" @default.
• W2033713750 creator A5055903272 @default.
• W2033713750 creator A5059467218 @default.
• W2033713750 creator A5060298854 @default.
• W2033713750 creator A5063047004 @default.
• W2033713750 creator A5074476359 @default.
• W2033713750 creator A5074550434 @default.
• W2033713750 creator A5075773160 @default.
• W2033713750 date "2006-12-01" @default.
• W2033713750 modified "2023-10-02" @default.
• W2033713750 title "Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress" @default.
• W2033713750 cites W139880502 @default.
• W2033713750 cites W1810460453 @default.
• W2033713750 cites W1908806204 @default.
• W2033713750 cites W1935064934 @default.
• W2033713750 cites W1971512681 @default.
• W2033713750 cites W1978784950 @default.
• W2033713750 cites W1984380517 @default.
• W2033713750 cites W1984662779 @default.
• W2033713750 cites W1997279776 @default.
• W2033713750 cites W2003347119 @default.
• W2033713750 cites W2005965768 @default.
• W2033713750 cites W2016803694 @default.
• W2033713750 cites W2026853182 @default.
• W2033713750 cites W2060234059 @default.
• W2033713750 cites W2064803824 @default.
• W2033713750 cites W2074020347 @default.
• W2033713750 cites W2075956591 @default.
• W2033713750 cites W2077174217 @default.
• W2033713750 cites W2083626903 @default.
• W2033713750 cites W2096487945 @default.
• W2033713750 cites W2126105025 @default.
• W2033713750 cites W2128154716 @default.
• W2033713750 cites W2137048653 @default.
• W2033713750 cites W2139656274 @default.
• W2033713750 cites W2143745192 @default.
• W2033713750 cites W2164294710 @default.
• W2033713750 cites W2166821055 @default.
• W2033713750 cites W2171654087 @default.
• W2033713750 cites W2414082932 @default.
• W2033713750 cites W88469083 @default.
• W2033713750 doi "https://doi.org/10.1210/jc.2006-0651" @default.
• W2033713750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16984982" @default.
• W2033713750 hasPublicationYear "2006" @default.
• W2033713750 type Work @default.
• W2033713750 sameAs 2033713750 @default.
• W2033713750 citedByCount "217" @default.
• W2033713750 countsByYear W20337137502012 @default.
• W2033713750 countsByYear W20337137502013 @default.
• W2033713750 countsByYear W20337137502014 @default.
• W2033713750 countsByYear W20337137502015 @default.
• W2033713750 countsByYear W20337137502016 @default.
• W2033713750 countsByYear W20337137502017 @default.
• W2033713750 countsByYear W20337137502018 @default.
• W2033713750 countsByYear W20337137502019 @default.
• W2033713750 countsByYear W20337137502020 @default.
• W2033713750 countsByYear W20337137502021 @default.
• W2033713750 countsByYear W20337137502022 @default.
• W2033713750 countsByYear W20337137502023 @default.
• W2033713750 crossrefType "journal-article" @default.
• W2033713750 hasAuthorship W2033713750A5055903272 @default.
• W2033713750 hasAuthorship W2033713750A5059467218 @default.
• W2033713750 hasAuthorship W2033713750A5060298854 @default.
• W2033713750 hasAuthorship W2033713750A5063047004 @default.
• W2033713750 hasAuthorship W2033713750A5074476359 @default.
• W2033713750 hasAuthorship W2033713750A5074550434 @default.
• W2033713750 hasAuthorship W2033713750A5075773160 @default.
• W2033713750 hasBestOaLocation W20337137501 @default.
• W2033713750 hasConcept C1008401 @default.
• W2033713750 hasConcept C120863210 @default.
• W2033713750 hasConcept C126322002 @default.
• W2033713750 hasConcept C134018914 @default.
• W2033713750 hasConcept C147583825 @default.
• W2033713750 hasConcept C185592680 @default.
• W2033713750 hasConcept C197683979 @default.
• W2033713750 hasConcept C2776214593 @default.
• W2033713750 hasConcept C2776263037 @default.
• W2033713750 hasConcept C2777431362 @default.
• W2033713750 hasConcept C2777854218 @default.
• W2033713750 hasConcept C2778709874 @default.
• W2033713750 hasConcept C2779572773 @default.
• W2033713750 hasConcept C2779959927 @default.
• W2033713750 hasConcept C2910616045 @default.
• W2033713750 hasConcept C515207424 @default.
• W2033713750 hasConcept C55493867 @default.
• W2033713750 hasConcept C62231903 @default.
• W2033713750 hasConcept C71924100 @default.
• W2033713750 hasConcept C96942376 @default.
• W2033713750 hasConceptScore W2033713750C1008401 @default.
• W2033713750 hasConceptScore W2033713750C120863210 @default.
• W2033713750 hasConceptScore W2033713750C126322002 @default.
• W2033713750 hasConceptScore W2033713750C134018914 @default.
• W2033713750 hasConceptScore W2033713750C147583825 @default.
• W2033713750 hasConceptScore W2033713750C185592680 @default.
• W2033713750 hasConceptScore W2033713750C197683979 @default.
• W2033713750 hasConceptScore W2033713750C2776214593 @default.
• W2033713750 hasConceptScore W2033713750C2776263037 @default.

• next