Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033715459> ?p ?o ?g. }
- W2033715459 endingPage "4789" @default.
- W2033715459 startingPage "4776" @default.
- W2033715459 abstract "Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular levels of proteins. Whereas de novo protein synthesis is a comparatively slow process, proteins are rapidly degraded at a rate compatible with the control of cell cycle transitions and cell death induction. A major pathway for protein degradation is initiated by the addition of multiple 76-amino acid ubiquitin monomers via a three-step process of ubiquitin activation and substrate recognition. Polyubiquitination targets proteins for recognition and processing by the 26S proteasome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recycles ubiquitin. The critical roles played by ubiquitin-mediated protein turnover in cell cycle regulation makes this process a target for oncogenic mutations. Oncogenes of several common malignancies, for example colon and renal cell cancer, code for ubiquitin ligase components. Cervical oncogenesis by human papillomavirus is also mediated by alteration of ubiquitin ligase pathways. Protein degradation pathways are also targets for cancer therapy, as shown by the successful introduction of bortezomib, an inhibitor of the 26S proteasome. Further work in this area holds great promise toward our understanding and treatment of a wide range of cancers." @default.
- W2033715459 created "2016-06-24" @default.
- W2033715459 creator A5051729520 @default.
- W2033715459 creator A5086050905 @default.
- W2033715459 date "2005-07-20" @default.
- W2033715459 modified "2023-10-17" @default.
- W2033715459 title "The Ubiquitin-Proteasome Pathway and Its Role in Cancer" @default.
- W2033715459 cites W133702455 @default.
- W2033715459 cites W135235169 @default.
- W2033715459 cites W1479851678 @default.
- W2033715459 cites W1489931243 @default.
- W2033715459 cites W1496897161 @default.
- W2033715459 cites W1497941038 @default.
- W2033715459 cites W1502675762 @default.
- W2033715459 cites W1510153624 @default.
- W2033715459 cites W1516397282 @default.
- W2033715459 cites W1517718286 @default.
- W2033715459 cites W1529177388 @default.
- W2033715459 cites W1529476232 @default.
- W2033715459 cites W153676044 @default.
- W2033715459 cites W1538028541 @default.
- W2033715459 cites W1539814399 @default.
- W2033715459 cites W1540183118 @default.
- W2033715459 cites W1546177497 @default.
- W2033715459 cites W1549375498 @default.
- W2033715459 cites W1552201117 @default.
- W2033715459 cites W1554815317 @default.
- W2033715459 cites W1558846872 @default.
- W2033715459 cites W1569755992 @default.
- W2033715459 cites W1573531091 @default.
- W2033715459 cites W1576686733 @default.
- W2033715459 cites W1582195464 @default.
- W2033715459 cites W1584082469 @default.
- W2033715459 cites W1620032110 @default.
- W2033715459 cites W1640635403 @default.
- W2033715459 cites W1646203193 @default.
- W2033715459 cites W1832030339 @default.
- W2033715459 cites W1856530031 @default.
- W2033715459 cites W1868874850 @default.
- W2033715459 cites W1889990604 @default.
- W2033715459 cites W190015672 @default.
- W2033715459 cites W1913862483 @default.
- W2033715459 cites W1958512987 @default.
- W2033715459 cites W1963533810 @default.
- W2033715459 cites W1963899781 @default.
- W2033715459 cites W1964918262 @default.
- W2033715459 cites W1965049479 @default.
- W2033715459 cites W1968229731 @default.
- W2033715459 cites W1969434750 @default.
- W2033715459 cites W1969807455 @default.
- W2033715459 cites W1970174108 @default.
- W2033715459 cites W1971254046 @default.
- W2033715459 cites W1971357333 @default.
- W2033715459 cites W1971376982 @default.
- W2033715459 cites W1972032694 @default.
- W2033715459 cites W1972220674 @default.
- W2033715459 cites W1972659631 @default.
- W2033715459 cites W1973422080 @default.
- W2033715459 cites W1973904343 @default.
- W2033715459 cites W1975460230 @default.
- W2033715459 cites W1975462016 @default.
- W2033715459 cites W1975993620 @default.
- W2033715459 cites W1978173977 @default.
- W2033715459 cites W1979408355 @default.
- W2033715459 cites W1979618971 @default.
- W2033715459 cites W1980189056 @default.
- W2033715459 cites W1981024715 @default.
- W2033715459 cites W1981864085 @default.
- W2033715459 cites W1981908755 @default.
- W2033715459 cites W1985009222 @default.
- W2033715459 cites W1985531090 @default.
- W2033715459 cites W1986464453 @default.
- W2033715459 cites W1986627314 @default.
- W2033715459 cites W1987605482 @default.
- W2033715459 cites W1988088522 @default.
- W2033715459 cites W1988617344 @default.
- W2033715459 cites W1988935612 @default.
- W2033715459 cites W1989382065 @default.
- W2033715459 cites W1989970319 @default.
- W2033715459 cites W1991494214 @default.
- W2033715459 cites W1991843895 @default.
- W2033715459 cites W1991915276 @default.
- W2033715459 cites W1995254238 @default.
- W2033715459 cites W1996015633 @default.
- W2033715459 cites W1996460413 @default.
- W2033715459 cites W1998790265 @default.
- W2033715459 cites W1999119754 @default.
- W2033715459 cites W1999998370 @default.
- W2033715459 cites W2001274114 @default.
- W2033715459 cites W2002404925 @default.
- W2033715459 cites W2003849992 @default.
- W2033715459 cites W2004759810 @default.
- W2033715459 cites W2005088732 @default.
- W2033715459 cites W2007249806 @default.
- W2033715459 cites W2008044453 @default.
- W2033715459 cites W2008415422 @default.
- W2033715459 cites W2008798771 @default.
- W2033715459 cites W2010369105 @default.