Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033718244> ?p ?o ?g. }
- W2033718244 endingPage "118" @default.
- W2033718244 startingPage "101" @default.
- W2033718244 abstract "Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response could be mediated by a feedback signaling pathway involving protein kinase C (PKC), p38 mitogen activated protein kinase (p38MAPK) and phospholipase C (PLC). Further, to elucidate the downstream effector pathway, we studied the X-ray-induced adaptive response in cultured mouse and human cells with different genetic background relevant to the DNA damage response pathway, such as deficiencies in TP53, DNA-PKcs, ATM and FANCA genes. The results showed that p53 protein played a key role in the adaptive response while DNA-PKcs, ATM and FANCA were not responsible. Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), mimicked the priming irradiation in that the inhibitor alone rendered the cells resistant against the induction of chromosome aberrations and apoptosis by the subsequent X-ray irradiation. The adaptive response, whether it was afforded by low-dose X-rays or wortmannin, occurred in parallel with the reduction of apoptotic cell death by challenging doses. The inhibitor of p38MAPK which blocks the adaptive response did not suppress apoptosis. These observations indicate that the adaptive response and apoptotic cell death constitute a complementary defense system via life-or-death decisions. The p53 has a pivotal role in channeling the radiation-induced DNA double-strand breaks (DSBs) into an adaptive legitimate repair pathway, where the signals are integrated into p53 by a circuitous PKC-p38MAPK-PLC damage sensing pathway, and hence turning off the signals to an alternative pathway to illegitimate repair and apoptosis. A possible molecular mechanism of adaptive response to low-dose ionizing irradiation has been discussed in relation to the repair of DSBs and implicated to the current controversial observations on the expression of adaptive response." @default.
- W2033718244 created "2016-06-24" @default.
- W2033718244 creator A5001843986 @default.
- W2033718244 creator A5026771975 @default.
- W2033718244 creator A5052954746 @default.
- W2033718244 creator A5061491197 @default.
- W2033718244 creator A5067788481 @default.
- W2033718244 creator A5077988648 @default.
- W2033718244 creator A5084395887 @default.
- W2033718244 date "2002-07-01" @default.
- W2033718244 modified "2023-10-06" @default.
- W2033718244 title "DNA damage response pathway in radioadaptive response" @default.
- W2033718244 cites W1543815058 @default.
- W2033718244 cites W1583256888 @default.
- W2033718244 cites W1623897355 @default.
- W2033718244 cites W1640195411 @default.
- W2033718244 cites W1650797637 @default.
- W2033718244 cites W1888473517 @default.
- W2033718244 cites W189821932 @default.
- W2033718244 cites W1966761762 @default.
- W2033718244 cites W1970232857 @default.
- W2033718244 cites W1972195403 @default.
- W2033718244 cites W1973505881 @default.
- W2033718244 cites W1974010399 @default.
- W2033718244 cites W1975644211 @default.
- W2033718244 cites W1976423026 @default.
- W2033718244 cites W1976445136 @default.
- W2033718244 cites W1977800776 @default.
- W2033718244 cites W1978122481 @default.
- W2033718244 cites W1978331091 @default.
- W2033718244 cites W1978863345 @default.
- W2033718244 cites W1983832776 @default.
- W2033718244 cites W1984755213 @default.
- W2033718244 cites W1985446280 @default.
- W2033718244 cites W1985999867 @default.
- W2033718244 cites W1986179131 @default.
- W2033718244 cites W1986320226 @default.
- W2033718244 cites W1990781647 @default.
- W2033718244 cites W1991841649 @default.
- W2033718244 cites W1993142423 @default.
- W2033718244 cites W1993276497 @default.
- W2033718244 cites W1993977673 @default.
- W2033718244 cites W1995284691 @default.
- W2033718244 cites W1995865760 @default.
- W2033718244 cites W1998530321 @default.
- W2033718244 cites W1999471119 @default.
- W2033718244 cites W2000216893 @default.
- W2033718244 cites W2000912535 @default.
- W2033718244 cites W2005946108 @default.
- W2033718244 cites W2006607764 @default.
- W2033718244 cites W2006613327 @default.
- W2033718244 cites W2007935491 @default.
- W2033718244 cites W2008258524 @default.
- W2033718244 cites W2008684482 @default.
- W2033718244 cites W2009291101 @default.
- W2033718244 cites W2010429822 @default.
- W2033718244 cites W2010901031 @default.
- W2033718244 cites W2011320725 @default.
- W2033718244 cites W2012090280 @default.
- W2033718244 cites W2012970337 @default.
- W2033718244 cites W2013233393 @default.
- W2033718244 cites W2014438192 @default.
- W2033718244 cites W2014722055 @default.
- W2033718244 cites W2017297714 @default.
- W2033718244 cites W2022762967 @default.
- W2033718244 cites W2030502631 @default.
- W2033718244 cites W2032621328 @default.
- W2033718244 cites W2033950216 @default.
- W2033718244 cites W2034562158 @default.
- W2033718244 cites W2035154953 @default.
- W2033718244 cites W2035852033 @default.
- W2033718244 cites W2035910115 @default.
- W2033718244 cites W2036771063 @default.
- W2033718244 cites W2039109181 @default.
- W2033718244 cites W2040169548 @default.
- W2033718244 cites W2041443477 @default.
- W2033718244 cites W2045214898 @default.
- W2033718244 cites W2045872949 @default.
- W2033718244 cites W2048458949 @default.
- W2033718244 cites W2048663295 @default.
- W2033718244 cites W2049422138 @default.
- W2033718244 cites W2052245510 @default.
- W2033718244 cites W2053926251 @default.
- W2033718244 cites W2054208935 @default.
- W2033718244 cites W2055109499 @default.
- W2033718244 cites W2055542550 @default.
- W2033718244 cites W2056036386 @default.
- W2033718244 cites W2056176935 @default.
- W2033718244 cites W2058601529 @default.
- W2033718244 cites W2058800908 @default.
- W2033718244 cites W2059760067 @default.
- W2033718244 cites W2061217748 @default.
- W2033718244 cites W2064795157 @default.
- W2033718244 cites W2065378097 @default.
- W2033718244 cites W2067984289 @default.
- W2033718244 cites W2068560989 @default.
- W2033718244 cites W2075883601 @default.
- W2033718244 cites W2075906592 @default.