FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033718576> ?p ?o ?g. }

• W2033718576 endingPage "2109" @default.
• W2033718576 startingPage "2098" @default.
• W2033718576 abstract "Magnetic Resonance Imaging (MRI) provides various imaging modes to study the brain. We tested the benefits of a joint analysis of multimodality MRI data in combination with a large-scale analysis that involved simultaneously all image voxels using joint independent components analysis (jICA) and compared the outcome to results using conventional voxel-by-voxel unimodality tests. Specifically, we designed a jICA to decompose multimodality MRI data into independent components that explain joint variations between the image modalities as well as variations across brain regions. We tested the jICA design on structural and perfusion-weighted MRI data from 12 patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and 12 cognitively normal elderly individuals. While unimodality analyses showed widespread brain atrophy and hypoperfusion in the patients, jICA further revealed two significant joint components of variations between atrophy and hypoperfusion across brain regions. The 1st joint component revealed associated brain atrophy and hypoperfusion predominantly in the right brain hemisphere in behavioral variant frontotemporal dementia, and the 2nd joint component revealed greater atrophy relative to hypoperfusion affecting predominantly the left hemisphere in behavioral variant frontotemporal dementia. The patterns are consistent with the clinical symptoms of behavioral variant frontotemporal dementia that relate to asymmetric compromises of the left and right brain hemispheres. The joint components also revealed that that structural alterations can be associated with physiological alterations in spatially separated but potentially connected brain regions. Finally, jICA outperformed voxel-by-voxel unimodal tests significantly in terms of an effect size, separating the behavioral variant frontotemporal dementia patients from the controls. Taken together, the results demonstrate the benefit of multimodality MRI in conjunction with jICA for mapping neurodegeneration, which may lead ultimately to an improved diagnosis of behavioral variant frontotemporal dementia and other forms of neurodegenerative diseases." @default.
• W2033718576 created "2016-06-24" @default.
• W2033718576 creator A5009052142 @default.
• W2033718576 creator A5043086041 @default.
• W2033718576 creator A5044485966 @default.
• W2033718576 creator A5046120768 @default.
• W2033718576 creator A5072009949 @default.
• W2033718576 date "2012-02-01" @default.
• W2033718576 modified "2023-10-15" @default.
• W2033718576 title "MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia" @default.
• W2033718576 cites W1515345627 @default.
• W2033718576 cites W1932510543 @default.
• W2033718576 cites W1944065075 @default.
• W2033718576 cites W1966848686 @default.
• W2033718576 cites W1973609741 @default.
• W2033718576 cites W1973913291 @default.
• W2033718576 cites W1974583546 @default.
• W2033718576 cites W1978161337 @default.
• W2033718576 cites W1983480505 @default.
• W2033718576 cites W1984148891 @default.
• W2033718576 cites W1994487817 @default.
• W2033718576 cites W1994839798 @default.
• W2033718576 cites W1996489679 @default.
• W2033718576 cites W1998328512 @default.
• W2033718576 cites W2004222997 @default.
• W2033718576 cites W2006412233 @default.
• W2033718576 cites W2013447183 @default.
• W2033718576 cites W2024576158 @default.
• W2033718576 cites W2024846174 @default.
• W2033718576 cites W2030063570 @default.
• W2033718576 cites W2034416540 @default.
• W2033718576 cites W2041161976 @default.
• W2033718576 cites W2049128488 @default.
• W2033718576 cites W205204687 @default.
• W2033718576 cites W2062004140 @default.
• W2033718576 cites W2063473981 @default.
• W2033718576 cites W2076960269 @default.
• W2033718576 cites W2079500256 @default.
• W2033718576 cites W2082207932 @default.
• W2033718576 cites W2085116579 @default.
• W2033718576 cites W2087167911 @default.
• W2033718576 cites W2093889187 @default.
• W2033718576 cites W2094843559 @default.
• W2033718576 cites W2103158542 @default.
• W2033718576 cites W2104289741 @default.
• W2033718576 cites W2109347546 @default.
• W2033718576 cites W2110065044 @default.
• W2033718576 cites W2111240150 @default.
• W2033718576 cites W2114133705 @default.
• W2033718576 cites W2115820990 @default.
• W2033718576 cites W2128058309 @default.
• W2033718576 cites W2129006179 @default.
• W2033718576 cites W2129821250 @default.
• W2033718576 cites W2130686832 @default.
• W2033718576 cites W2130762902 @default.
• W2033718576 cites W2135304097 @default.
• W2033718576 cites W2137161718 @default.
• W2033718576 cites W2141279969 @default.
• W2033718576 cites W2144773945 @default.
• W2033718576 cites W2145714441 @default.
• W2033718576 cites W2151227755 @default.
• W2033718576 cites W2154633730 @default.
• W2033718576 cites W2159763350 @default.
• W2033718576 cites W2161591846 @default.
• W2033718576 cites W2162290386 @default.
• W2033718576 cites W2162615138 @default.
• W2033718576 doi "https://doi.org/10.1016/j.neuroimage.2011.10.031" @default.
• W2033718576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3254855" @default.
• W2033718576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22036676" @default.
• W2033718576 hasPublicationYear "2012" @default.
• W2033718576 type Work @default.
• W2033718576 sameAs 2033718576 @default.
• W2033718576 citedByCount "15" @default.
• W2033718576 countsByYear W20337185762013 @default.
• W2033718576 countsByYear W20337185762014 @default.
• W2033718576 countsByYear W20337185762015 @default.
• W2033718576 countsByYear W20337185762016 @default.
• W2033718576 countsByYear W20337185762017 @default.
• W2033718576 countsByYear W20337185762018 @default.
• W2033718576 countsByYear W20337185762019 @default.
• W2033718576 crossrefType "journal-article" @default.
• W2033718576 hasAuthorship W2033718576A5009052142 @default.
• W2033718576 hasAuthorship W2033718576A5043086041 @default.
• W2033718576 hasAuthorship W2033718576A5044485966 @default.
• W2033718576 hasAuthorship W2033718576A5046120768 @default.
• W2033718576 hasAuthorship W2033718576A5072009949 @default.
• W2033718576 hasBestOaLocation W20337185762 @default.
• W2033718576 hasConcept C126838900 @default.
• W2033718576 hasConcept C142724271 @default.
• W2033718576 hasConcept C143409427 @default.
• W2033718576 hasConcept C15744967 @default.
• W2033718576 hasConcept C169760540 @default.
• W2033718576 hasConcept C2778641062 @default.
• W2033718576 hasConcept C2779134260 @default.
• W2033718576 hasConcept C2779483572 @default.
• W2033718576 hasConcept C2781172350 @default.
• W2033718576 hasConcept C54170458 @default.
• W2033718576 hasConcept C71924100 @default.

• next