FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033723622> ?p ?o ?g. }

• W2033723622 endingPage "365" @default.
• W2033723622 startingPage "358" @default.
• W2033723622 abstract "<i>Background:</i> α-Interferon, thalidomide and celecoxib inhibit tumour angiogenesis by differing mechanisms. <i>Patients and Methods:</i> In a randomized phase II trial to assess tolerability and safety, we assigned patients with advanced slow-growing solid tumours to 1 of 6 two- or three-drug combinations: α-interferon 0.5 million IU b.i.d., thalidomide (100 mg b.i.d. reduced to 100 mg daily), or celecoxib (400 mg daily reduced to 200 mg). Circulating endothelial cells and progenitors (CECs, CEPs) and vascular endothelial growth factor were also studied. <i>Results:</i> From January 2002 to September 2005, 62 patients were enrolled. Four months after initiating treatment, 3 (4%) had partial response, 40 (64%) had stable disease and 19 (30%) had disease progression. Median duration of clinical benefit (partial response/stable disease) was 11.3 months. Patients receiving a third drug had significantly less stable disease plus partial response (χ² test, p = 0.002) than those receiving two drugs. The treatments were generally well tolerated, but neurotoxicity (G3 lethargy) occurred in 6 patients. Baseline CEPs were lower (p = 0.004) in patients with clinical benefit at 6 months than those without benefit. After 2 months of treatment CECs were lower than at baseline (p = 0.018) in patients without clinical benefit, and CEPs were higher than at baseline (p = 0.003) in patients with benefit. <i>Conclusions:</i> In pretreated patients with advanced slow-growing solid tumours, long-term metronomic administration of two-drug combinations of α-interferon, thalidomide or celecoxib was well tolerated and had antitumour activity. Low baseline CEPs in patients with subsequent clinical benefit suggest that CEC count may identify patients likely to benefit from long-term metronomic anti-angiogenic treatment." @default.
• W2033723622 created "2016-06-24" @default.
• W2033723622 creator A5003897511 @default.
• W2033723622 creator A5007502698 @default.
• W2033723622 creator A5031697040 @default.
• W2033723622 creator A5034667041 @default.
• W2033723622 creator A5040885322 @default.
• W2033723622 creator A5042749385 @default.
• W2033723622 creator A5052353123 @default.
• W2033723622 creator A5062234802 @default.
• W2033723622 creator A5064646828 @default.
• W2033723622 creator A5067487266 @default.
• W2033723622 creator A5069268885 @default.
• W2033723622 creator A5069836898 @default.
• W2033723622 creator A5079789461 @default.
• W2033723622 creator A5085512648 @default.
• W2033723622 creator A5086260594 @default.
• W2033723622 date "2009-01-01" @default.
• W2033723622 modified "2023-10-17" @default.
• W2033723622 title "Safety, Tolerability and Biological Effects of Long-Term Metronomic Administration of Non-Cytotoxic Anti-Angiogenic Agents" @default.
• W2033723622 cites W110134706 @default.
• W2033723622 cites W1679125225 @default.
• W2033723622 cites W1857696541 @default.
• W2033723622 cites W1912068049 @default.
• W2033723622 cites W1968539943 @default.
• W2033723622 cites W1971837077 @default.
• W2033723622 cites W1978139448 @default.
• W2033723622 cites W1978855912 @default.
• W2033723622 cites W1984750597 @default.
• W2033723622 cites W1985147506 @default.
• W2033723622 cites W2002238933 @default.
• W2033723622 cites W2004919077 @default.
• W2033723622 cites W2021547142 @default.
• W2033723622 cites W2027943349 @default.
• W2033723622 cites W2032175563 @default.
• W2033723622 cites W2049051984 @default.
• W2033723622 cites W2079738711 @default.
• W2033723622 cites W2100669312 @default.
• W2033723622 cites W2100945863 @default.
• W2033723622 cites W2103245619 @default.
• W2033723622 cites W2104316189 @default.
• W2033723622 cites W2108773352 @default.
• W2033723622 cites W2109134893 @default.
• W2033723622 cites W2117013761 @default.
• W2033723622 cites W2117859020 @default.
• W2033723622 cites W2118691146 @default.
• W2033723622 cites W2119689902 @default.
• W2033723622 cites W2136082633 @default.
• W2033723622 cites W2136783006 @default.
• W2033723622 cites W2139248078 @default.
• W2033723622 cites W2149026055 @default.
• W2033723622 cites W2149456801 @default.
• W2033723622 cites W2157769714 @default.
• W2033723622 cites W2163899134 @default.
• W2033723622 cites W2318749957 @default.
• W2033723622 cites W2336169581 @default.
• W2033723622 cites W3139763557 @default.
• W2033723622 doi "https://doi.org/10.1159/000275830" @default.
• W2033723622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20068365" @default.
• W2033723622 hasPublicationYear "2009" @default.
• W2033723622 type Work @default.
• W2033723622 sameAs 2033723622 @default.
• W2033723622 citedByCount "7" @default.
• W2033723622 countsByYear W20337236222012 @default.
• W2033723622 countsByYear W20337236222013 @default.
• W2033723622 countsByYear W20337236222014 @default.
• W2033723622 countsByYear W20337236222017 @default.
• W2033723622 crossrefType "journal-article" @default.
• W2033723622 hasAuthorship W2033723622A5003897511 @default.
• W2033723622 hasAuthorship W2033723622A5007502698 @default.
• W2033723622 hasAuthorship W2033723622A5031697040 @default.
• W2033723622 hasAuthorship W2033723622A5034667041 @default.
• W2033723622 hasAuthorship W2033723622A5040885322 @default.
• W2033723622 hasAuthorship W2033723622A5042749385 @default.
• W2033723622 hasAuthorship W2033723622A5052353123 @default.
• W2033723622 hasAuthorship W2033723622A5062234802 @default.
• W2033723622 hasAuthorship W2033723622A5064646828 @default.
• W2033723622 hasAuthorship W2033723622A5067487266 @default.
• W2033723622 hasAuthorship W2033723622A5069268885 @default.
• W2033723622 hasAuthorship W2033723622A5069836898 @default.
• W2033723622 hasAuthorship W2033723622A5079789461 @default.
• W2033723622 hasAuthorship W2033723622A5085512648 @default.
• W2033723622 hasAuthorship W2033723622A5086260594 @default.
• W2033723622 hasConcept C126322002 @default.
• W2033723622 hasConcept C197934379 @default.
• W2033723622 hasConcept C2776364478 @default.
• W2033723622 hasConcept C2776467144 @default.
• W2033723622 hasConcept C2777260799 @default.
• W2033723622 hasConcept C2778375690 @default.
• W2033723622 hasConcept C2779609412 @default.
• W2033723622 hasConcept C29730261 @default.
• W2033723622 hasConcept C31760486 @default.
• W2033723622 hasConcept C71924100 @default.
• W2033723622 hasConcept C90924648 @default.
• W2033723622 hasConcept C98274493 @default.
• W2033723622 hasConceptScore W2033723622C126322002 @default.
• W2033723622 hasConceptScore W2033723622C197934379 @default.
• W2033723622 hasConceptScore W2033723622C2776364478 @default.

• next