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• W2033728664 abstract "The sincerest form of flattery! A novel, symmetric lipid A mimetic (D1) formed by two glucose units linked through a 6-6' succinic diamide linker is active in modulating the activity of human TLR4. D1 inhibits endotoxin-stimulated TLR4 activation by inhibiting interaction of endotoxin with both receptors CD14 and MD-2 (associated to TLR4). D1 also has weak TLR4 agonist activity that makes it a promising lead compound for development as a vaccine adjuvant." @default.
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• W2033728664 date "2011-12-02" @default.
• W2033728664 modified "2023-10-12" @default.
• W2033728664 title "A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity" @default.
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• W2033728664 doi "https://doi.org/10.1002/cmdc.201100494" @default.
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