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- W2033743648 abstract "We performed Southern analysis of mitochondrial DNA (mtDNA) in 6 tissues from a patient with Kearns-Sayre syndrome and found a single deletion of 4.9 kb in all tissues. The percentage of deleted mtDNAs varied widely between tissues, from only 4% in smooth muscle to approximately 50% in skeletal muscle. Samples of DNA obtained from 3 different skeletal muscles and from separate areas of individual tissues showed little variation in percentage of deleted mtDNA. Biochemical analysis showed no clear correlation between mitochondrial enzyme activity and deleted mtDNAs." @default.
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- W2033743648 date "1990-01-01" @default.
- W2033743648 modified "2023-09-23" @default.
- W2033743648 title "Widespread tissue distribution of mitochondrial DNA deletions in Kearns-Sayre syndrome" @default.
- W2033743648 doi "https://doi.org/10.1212/wnl.40.1.24" @default.
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