FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033751129> ?p ?o ?g. }

• W2033751129 endingPage "972" @default.
• W2033751129 startingPage "967" @default.
• W2033751129 abstract "GSK-3β is a key molecule in several signalling pathways, including the Wnt/β-catenin signalling pathway. There is increasing evidence suggesting Wnt/β-catenin signalling is involved in the neural differentiation of embryonic, somatic and neural stem cells. However, a large body of evidence indicates that this pathway maintains stem cells in a proliferative state. To address this controversy, we have investigated whether the Wnt/β-catenin pathway is present and involved in the neural differentiation of newly introduced USSCs (unrestricted somatic stem cells). Our results indicate that the components of Wnt/β-catenin signalling are present in undifferentiated USSCs. We also show that the treatment of neurally induced USSCs with BIO (6-bromoindirubin-3′-oxime), a specific GSK-3β inhibitor and Wnt activator, for 5 and 10 days results in increased expression of a general neuronal marker (β-tubulin III). Moreover, the expression of pGSK-3β and stabilized β-catenin increased by BIO in neurally induced USSCs, indicates that the Wnt pathway is activated and functional in these cells. Thus, inhibition of GSK-3β in USSCs enhances their neural differentiation, which suggests a positive role of the Wnt/β-catenin signalling pathway towards neural fate." @default.
• W2033751129 created "2016-06-24" @default.
• W2033751129 creator A5003103139 @default.
• W2033751129 creator A5008190274 @default.
• W2033751129 creator A5021683396 @default.
• W2033751129 creator A5023964416 @default.
• W2033751129 creator A5052275537 @default.
• W2033751129 creator A5061761348 @default.
• W2033751129 creator A5066107059 @default.
• W2033751129 creator A5074024316 @default.
• W2033751129 creator A5080690872 @default.
• W2033751129 date "2012-09-17" @default.
• W2033751129 modified "2023-09-25" @default.
• W2033751129 title "Inhibition of GSK-3β enhances neural differentiation in unrestricted somatic stem cells" @default.
• W2033751129 cites W1492625577 @default.
• W2033751129 cites W1603850560 @default.
• W2033751129 cites W1968463611 @default.
• W2033751129 cites W1974033361 @default.
• W2033751129 cites W1974954301 @default.
• W2033751129 cites W1975703347 @default.
• W2033751129 cites W1984066326 @default.
• W2033751129 cites W1998542618 @default.
• W2033751129 cites W2007691512 @default.
• W2033751129 cites W2021226225 @default.
• W2033751129 cites W2028051736 @default.
• W2033751129 cites W2038084705 @default.
• W2033751129 cites W2040743545 @default.
• W2033751129 cites W2041534255 @default.
• W2033751129 cites W2041790420 @default.
• W2033751129 cites W2050843642 @default.
• W2033751129 cites W2062934426 @default.
• W2033751129 cites W2081152834 @default.
• W2033751129 cites W2082773762 @default.
• W2033751129 cites W2087124418 @default.
• W2033751129 cites W2089426706 @default.
• W2033751129 cites W2103279053 @default.
• W2033751129 cites W2119284420 @default.
• W2033751129 cites W2132339263 @default.
• W2033751129 cites W2135908086 @default.
• W2033751129 cites W2147164277 @default.
• W2033751129 doi "https://doi.org/10.1042/cbi20110541" @default.
• W2033751129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22775567" @default.
• W2033751129 hasPublicationYear "2012" @default.
• W2033751129 type Work @default.
• W2033751129 sameAs 2033751129 @default.
• W2033751129 citedByCount "18" @default.
• W2033751129 countsByYear W20337511292012 @default.
• W2033751129 countsByYear W20337511292013 @default.
• W2033751129 countsByYear W20337511292014 @default.
• W2033751129 countsByYear W20337511292015 @default.
• W2033751129 countsByYear W20337511292016 @default.
• W2033751129 countsByYear W20337511292018 @default.
• W2033751129 countsByYear W20337511292019 @default.
• W2033751129 countsByYear W20337511292020 @default.
• W2033751129 countsByYear W20337511292022 @default.
• W2033751129 countsByYear W20337511292023 @default.
• W2033751129 crossrefType "journal-article" @default.
• W2033751129 hasAuthorship W2033751129A5003103139 @default.
• W2033751129 hasAuthorship W2033751129A5008190274 @default.
• W2033751129 hasAuthorship W2033751129A5021683396 @default.
• W2033751129 hasAuthorship W2033751129A5023964416 @default.
• W2033751129 hasAuthorship W2033751129A5052275537 @default.
• W2033751129 hasAuthorship W2033751129A5061761348 @default.
• W2033751129 hasAuthorship W2033751129A5066107059 @default.
• W2033751129 hasAuthorship W2033751129A5074024316 @default.
• W2033751129 hasAuthorship W2033751129A5080690872 @default.
• W2033751129 hasConcept C104317684 @default.
• W2033751129 hasConcept C136834591 @default.
• W2033751129 hasConcept C137620995 @default.
• W2033751129 hasConcept C145103041 @default.
• W2033751129 hasConcept C148738053 @default.
• W2033751129 hasConcept C185592680 @default.
• W2033751129 hasConcept C28328180 @default.
• W2033751129 hasConcept C30145163 @default.
• W2033751129 hasConcept C55493867 @default.
• W2033751129 hasConcept C62478195 @default.
• W2033751129 hasConcept C86803240 @default.
• W2033751129 hasConcept C95444343 @default.
• W2033751129 hasConceptScore W2033751129C104317684 @default.
• W2033751129 hasConceptScore W2033751129C136834591 @default.
• W2033751129 hasConceptScore W2033751129C137620995 @default.
• W2033751129 hasConceptScore W2033751129C145103041 @default.
• W2033751129 hasConceptScore W2033751129C148738053 @default.
• W2033751129 hasConceptScore W2033751129C185592680 @default.
• W2033751129 hasConceptScore W2033751129C28328180 @default.
• W2033751129 hasConceptScore W2033751129C30145163 @default.
• W2033751129 hasConceptScore W2033751129C55493867 @default.
• W2033751129 hasConceptScore W2033751129C62478195 @default.
• W2033751129 hasConceptScore W2033751129C86803240 @default.
• W2033751129 hasConceptScore W2033751129C95444343 @default.
• W2033751129 hasIssue "11" @default.
• W2033751129 hasLocation W20337511291 @default.
• W2033751129 hasLocation W20337511292 @default.
• W2033751129 hasOpenAccess W2033751129 @default.
• W2033751129 hasPrimaryLocation W20337511291 @default.
• W2033751129 hasRelatedWork W1968461724 @default.
• W2033751129 hasRelatedWork W1992313721 @default.
• W2033751129 hasRelatedWork W1997752936 @default.

• next