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- W2033758973 abstract "Background: Increased IL-1 production is associated with chronic obstructive pulmonary disease (COPD) in the adult and with bronchopulmonary dysplasia (BPD) in the premature newborns. We have studied the actions of IL-1 in developing and mature lungs using a transgenic mouse with regulatable IL-1 expression in the lung epithelium. Induction of IL-1 expression in the lungs of fetal and newborn mice leads to impaired alveolarization (decreased alveolar number and increased alveolar size). Induction of IL-1 expression in the adult mouse, on the other hand, causes emphysema. Clinical studies and studies in adult animals provide convincing evidence that MMP-9 and MMP-12 play important roles in emphysema in the adult. We hypothesize that MMP-9 and MMP-12 are mediators of lung remodeling also in the developing lung. Objective: To study the mRNA expression and protein production of MMP-9 and MMP-12 in fetal and newborn mice overexpressing IL-1 and in their nontransgenic littermates. Methods: MMP-9 and MMP-12 mRNA expression was studied by real-time RT-PCR using primers specific for murine MMP-9 and -12. Immunohistochemistry was used to detect MMP-9 and -12 protein in paraffin-embedded lung sections (antibodies from R&D Systems and Santa Cruz Biotechnology, respectively). Results: MMP-9 and–12 mRNA expression at different antenatal and postnatal ages is shown below (figure; statistical significance (p<0,05) indicated by asterisk). Immunostaining for both MMPs was increased in transgenic animals at all ages studied. Conclusion: 1) The production of MMP-9 and MMP-12 is higher in IL-1 overexpressing mice than in their nontransgenic littermates both antenatally and postnatally. 2) In both IL-1 overexpressing and wild-type mice, the expression of MMP-9 and MMP-12 increases at birth. The possibility that inhibiting MMP action prevents or alleviates lung injury caused by inflammatory mediators in the newborn remains to be explored." @default.
- W2033758973 created "2016-06-24" @default.
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- W2033758973 date "2004-09-01" @default.
- W2033758973 modified "2023-10-18" @default.
- W2033758973 title "43 Increased MMP-9 and MMP-12 Production in The Lungs of Fetal and Newborn Transgenic Mice Expressing IL-1 in The Pulmonary Epithelium" @default.
- W2033758973 doi "https://doi.org/10.1203/00006450-200409000-00066" @default.
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