FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033760528> ?p ?o ?g. }

• W2033760528 abstract "Based on known anatomy and physiology, we present a hypothesis where the basal ganglia motor loop is hierarchically organized in two main subsystems: the arbitration system and the extension system. The arbitration system, comprised of the subthalamic nucleus, globus pallidus, and pedunculopontine nucleus, serves the role of selecting one out of several candidate actions as they are ascending from various brain stem motor regions and aggregated in the centromedian thalamus or descending from the extension system or from the cerebral cortex. This system is an action-input/action-output system whose winner-take-all mechanism finds the strongest response among several candidates to execute. This decision is communicated back to the brain stem by facilitating the desired action via cholinergic/glutamatergic projections and suppressing conflicting alternatives via GABAergic connections. The extension system, comprised of the striatum and, again, globus pallidus, can extend the repertoire of responses by learning to associate novel complex states to certain actions. This system is a state-input/action-output system, whose organization enables it to encode arbitrarily complex Boolean logic rules using striatal neurons that only fire given specific constellations of inputs (Boolean AND) and pallidal neurons that are silenced by any striatal input (Boolean OR). We demonstrate the capabilities of this hierarchical system by a computational model where a simulated generic animal interacts with an environment by selecting direction of movement based on combinations of sensory stimuli, some being appetitive, others aversive or neutral. While the arbitration system can autonomously handle conflicting actions proposed by brain stem motor nuclei, the extension system is required to execute learned actions not suggested by external motor centers. Being precise in the functional role of each component of the system, this hypothesis generates several readily testable predictions." @default.
• W2033760528 created "2016-06-24" @default.
• W2033760528 creator A5020058515 @default.
• W2033760528 creator A5038133032 @default.
• W2033760528 creator A5041746692 @default.
• W2033760528 creator A5084813027 @default.
• W2033760528 date "2011-01-01" @default.
• W2033760528 modified "2023-10-12" @default.
• W2033760528 title "The Arbitration–Extension Hypothesis: A Hierarchical Interpretation of the Functional Organization of the Basal Ganglia" @default.
• W2033760528 cites W1517107662 @default.
• W2033760528 cites W1558712609 @default.
• W2033760528 cites W1807195566 @default.
• W2033760528 cites W1906118694 @default.
• W2033760528 cites W1964962588 @default.
• W2033760528 cites W1966511690 @default.
• W2033760528 cites W1970239939 @default.
• W2033760528 cites W1970994015 @default.
• W2033760528 cites W1971797700 @default.
• W2033760528 cites W1976284302 @default.
• W2033760528 cites W1976504167 @default.
• W2033760528 cites W1977831899 @default.
• W2033760528 cites W1984725541 @default.
• W2033760528 cites W1985908228 @default.
• W2033760528 cites W1992092449 @default.
• W2033760528 cites W1992356214 @default.
• W2033760528 cites W1992654377 @default.
• W2033760528 cites W1994314486 @default.
• W2033760528 cites W1996535168 @default.
• W2033760528 cites W1998604625 @default.
• W2033760528 cites W2000164389 @default.
• W2033760528 cites W2005269174 @default.
• W2033760528 cites W2006414608 @default.
• W2033760528 cites W2019981460 @default.
• W2033760528 cites W2020887697 @default.
• W2033760528 cites W2020925019 @default.
• W2033760528 cites W2026547228 @default.
• W2033760528 cites W2035235513 @default.
• W2033760528 cites W2044011743 @default.
• W2033760528 cites W2047471489 @default.
• W2033760528 cites W2048213664 @default.
• W2033760528 cites W2054520155 @default.
• W2033760528 cites W2055627408 @default.
• W2033760528 cites W2058955351 @default.
• W2033760528 cites W2060588252 @default.
• W2033760528 cites W2062859517 @default.
• W2033760528 cites W2071962431 @default.
• W2033760528 cites W2075021671 @default.
• W2033760528 cites W2078014777 @default.
• W2033760528 cites W2083141675 @default.
• W2033760528 cites W2085449697 @default.
• W2033760528 cites W2086632664 @default.
• W2033760528 cites W2087470047 @default.
• W2033760528 cites W2087861759 @default.
• W2033760528 cites W2095693723 @default.
• W2033760528 cites W2099652807 @default.
• W2033760528 cites W2102248966 @default.
• W2033760528 cites W2107199167 @default.
• W2033760528 cites W2108085425 @default.
• W2033760528 cites W2127819582 @default.
• W2033760528 cites W2128464706 @default.
• W2033760528 cites W2130421880 @default.
• W2033760528 cites W2137569707 @default.
• W2033760528 cites W2145932718 @default.
• W2033760528 cites W2149661045 @default.
• W2033760528 cites W2153562927 @default.
• W2033760528 cites W2156969587 @default.
• W2033760528 cites W2160270305 @default.
• W2033760528 cites W2171706375 @default.
• W2033760528 cites W2402404590 @default.
• W2033760528 cites W83308578 @default.
• W2033760528 doi "https://doi.org/10.3389/fnsys.2011.00013" @default.
• W2033760528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3061412" @default.
• W2033760528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21441994" @default.
• W2033760528 hasPublicationYear "2011" @default.
• W2033760528 type Work @default.
• W2033760528 sameAs 2033760528 @default.
• W2033760528 citedByCount "14" @default.
• W2033760528 countsByYear W20337605282013 @default.
• W2033760528 countsByYear W20337605282014 @default.
• W2033760528 countsByYear W20337605282015 @default.
• W2033760528 countsByYear W20337605282016 @default.
• W2033760528 countsByYear W20337605282017 @default.
• W2033760528 countsByYear W20337605282019 @default.
• W2033760528 countsByYear W20337605282020 @default.
• W2033760528 countsByYear W20337605282021 @default.
• W2033760528 crossrefType "journal-article" @default.
• W2033760528 hasAuthorship W2033760528A5020058515 @default.
• W2033760528 hasAuthorship W2033760528A5038133032 @default.
• W2033760528 hasAuthorship W2033760528A5041746692 @default.
• W2033760528 hasAuthorship W2033760528A5084813027 @default.
• W2033760528 hasBestOaLocation W20337605281 @default.
• W2033760528 hasConcept C142724271 @default.
• W2033760528 hasConcept C15744967 @default.
• W2033760528 hasConcept C160151201 @default.
• W2033760528 hasConcept C166109690 @default.
• W2033760528 hasConcept C169760540 @default.
• W2033760528 hasConcept C171139928 @default.
• W2033760528 hasConcept C17744445 @default.
• W2033760528 hasConcept C199539241 @default.
• W2033760528 hasConcept C26760741 @default.

• next