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- W2033763054 abstract "ICR male mice were fed diets containing 0, 1, 25, or 100 ppm of polybrominated biphenyls (PBB) for 14 days prior to challenge with a single injection of chloroform (CHCl3). Dietary PBB potentiated the CHCl3-induced depression of p-aminohippurate accumulation by slices of renal cortex and the CHCl3-induced rise in blood urea nitrogen concentration in a PBB-intake-related manner. The kidney weight-to-body weight ratio was elevated in PBB mice but not in mice consuming control (0 ppm) diet following administration of 50 μl/kg of CHCl3. Mice ingesting food containing 100 ppm of PBB also exhibited a greater increase in serum glutamic-oxaloacetic transaminase activity than did control mice following CHCl3 administration. The 24-hr LD50 of CHCl3 in control mice was 1.28 ml/kg, while that in mice consuming 100 ppm of PBB was 0.62 ml/kg." @default.
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- W2033763054 title "Polybrominated biphenyl-induced potentiation of chloroform toxicity" @default.
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- W2033763054 doi "https://doi.org/10.1016/0041-008x(78)90177-1" @default.
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