Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033774084> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2033774084 endingPage "115" @default.
- W2033774084 startingPage "109" @default.
- W2033774084 abstract "Tissue accumulation of intermediates of the metabolism occurs in various inherited neurodegenerative disorders, including methylmalonic acidemia (MA). Animal cognition is usually tested by measuring learning/memory of rats in behavioral tasks. A procedure in which rats are chronically injected with the metabolites accumulating in the neurometabolic disorder methylmalonic acidemia from the 5th to the 28th day of life is described. The animals were allowed to recover for approximately 30 days, after which they were submitted to the Morris water maze task. This behavioral task consisted of two steps. The first one is called the acquisition phase, where rats were trained for 5 consecutive days performing four trials per day to find the submerged platform. On each trial, the rat was placed in the water in one of four start locations (N, S, W and E). The animal was then allowed to search for the platform for 60 s. Once the rat located the platform, it was permitted to remain on it for 10 s. The acquisition phase was followed by the probe trial 24 h later, in which the platform is not present. The time spent in the quadrant of the former platform position and the correct annulus crossings were obtained as a measure for spatial memory. The next step was the reversal learning (reversal phase) performed 2 weeks later. Animals were trained for 4 days (four trials per day) to find the hidden platform, which had now been moved to a position diagonally opposite (reversed) from its location in the acquisition phase. On the next day, all animals were submitted to a second probe trial, similar to the first one. We observed that rats chronically injected with methylmalonic acid (MA), although presenting no alterations in the acquisition phase, showed a long lasting reversal learning impairment. Moreover, motor activity, evaluated by the swim speed in the maze, was not altered by MA administration. These results are consistent with perseverative behavior." @default.
- W2033774084 created "2016-06-24" @default.
- W2033774084 creator A5002304573 @default.
- W2033774084 creator A5023267415 @default.
- W2033774084 creator A5026452818 @default.
- W2033774084 creator A5028727993 @default.
- W2033774084 creator A5047957337 @default.
- W2033774084 creator A5087355116 @default.
- W2033774084 date "2003-10-01" @default.
- W2033774084 modified "2023-10-18" @default.
- W2033774084 title "Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task" @default.
- W2033774084 cites W1798106032 @default.
- W2033774084 cites W1964469142 @default.
- W2033774084 cites W1972090364 @default.
- W2033774084 cites W1986704392 @default.
- W2033774084 cites W1987755799 @default.
- W2033774084 cites W2017169966 @default.
- W2033774084 cites W2033599244 @default.
- W2033774084 cites W2037483083 @default.
- W2033774084 cites W2070862983 @default.
- W2033774084 cites W2076328592 @default.
- W2033774084 cites W2080349713 @default.
- W2033774084 cites W2092143963 @default.
- W2033774084 cites W2093084011 @default.
- W2033774084 doi "https://doi.org/10.1016/j.brainresprot.2003.09.002" @default.
- W2033774084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14613813" @default.
- W2033774084 hasPublicationYear "2003" @default.
- W2033774084 type Work @default.
- W2033774084 sameAs 2033774084 @default.
- W2033774084 citedByCount "9" @default.
- W2033774084 countsByYear W20337740842013 @default.
- W2033774084 countsByYear W20337740842016 @default.
- W2033774084 crossrefType "journal-article" @default.
- W2033774084 hasAuthorship W2033774084A5002304573 @default.
- W2033774084 hasAuthorship W2033774084A5023267415 @default.
- W2033774084 hasAuthorship W2033774084A5026452818 @default.
- W2033774084 hasAuthorship W2033774084A5028727993 @default.
- W2033774084 hasAuthorship W2033774084A5047957337 @default.
- W2033774084 hasAuthorship W2033774084A5087355116 @default.
- W2033774084 hasConcept C12515866 @default.
- W2033774084 hasConcept C126322002 @default.
- W2033774084 hasConcept C15744967 @default.
- W2033774084 hasConcept C162324750 @default.
- W2033774084 hasConcept C169760540 @default.
- W2033774084 hasConcept C169900460 @default.
- W2033774084 hasConcept C187736073 @default.
- W2033774084 hasConcept C2778159418 @default.
- W2033774084 hasConcept C2780451532 @default.
- W2033774084 hasConcept C2781161787 @default.
- W2033774084 hasConcept C2985665543 @default.
- W2033774084 hasConcept C42407357 @default.
- W2033774084 hasConcept C44752575 @default.
- W2033774084 hasConcept C548259974 @default.
- W2033774084 hasConcept C71924100 @default.
- W2033774084 hasConcept C99508421 @default.
- W2033774084 hasConceptScore W2033774084C12515866 @default.
- W2033774084 hasConceptScore W2033774084C126322002 @default.
- W2033774084 hasConceptScore W2033774084C15744967 @default.
- W2033774084 hasConceptScore W2033774084C162324750 @default.
- W2033774084 hasConceptScore W2033774084C169760540 @default.
- W2033774084 hasConceptScore W2033774084C169900460 @default.
- W2033774084 hasConceptScore W2033774084C187736073 @default.
- W2033774084 hasConceptScore W2033774084C2778159418 @default.
- W2033774084 hasConceptScore W2033774084C2780451532 @default.
- W2033774084 hasConceptScore W2033774084C2781161787 @default.
- W2033774084 hasConceptScore W2033774084C2985665543 @default.
- W2033774084 hasConceptScore W2033774084C42407357 @default.
- W2033774084 hasConceptScore W2033774084C44752575 @default.
- W2033774084 hasConceptScore W2033774084C548259974 @default.
- W2033774084 hasConceptScore W2033774084C71924100 @default.
- W2033774084 hasConceptScore W2033774084C99508421 @default.
- W2033774084 hasIssue "2" @default.
- W2033774084 hasLocation W20337740841 @default.
- W2033774084 hasLocation W20337740842 @default.
- W2033774084 hasOpenAccess W2033774084 @default.
- W2033774084 hasPrimaryLocation W20337740841 @default.
- W2033774084 hasRelatedWork W1935714934 @default.
- W2033774084 hasRelatedWork W1974208459 @default.
- W2033774084 hasRelatedWork W1976501505 @default.
- W2033774084 hasRelatedWork W2027168080 @default.
- W2033774084 hasRelatedWork W2033774084 @default.
- W2033774084 hasRelatedWork W2080568176 @default.
- W2033774084 hasRelatedWork W2085032350 @default.
- W2033774084 hasRelatedWork W2157871530 @default.
- W2033774084 hasRelatedWork W2381750903 @default.
- W2033774084 hasRelatedWork W2384133576 @default.
- W2033774084 hasVolume "12" @default.
- W2033774084 isParatext "false" @default.
- W2033774084 isRetracted "false" @default.
- W2033774084 magId "2033774084" @default.
- W2033774084 workType "article" @default.