FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033779758> ?p ?o ?g. }

• W2033779758 endingPage "e26548" @default.
• W2033779758 startingPage "e26548" @default.
• W2033779758 abstract "Caenorhabditis elegans GLD-1, a maxi-KH motif containing RNA-binding protein, has various functions mainly during female germ cell development, suggesting that it likely controls the expression of a selective group of maternal mRNAs. To gain an insight into how GLD-1 specifically recognizes these mRNA targets, we identified 38 biochemically proven GLD-1 binding regions from multiple mRNA targets that are among over 100 putative targets co-immunoprecipitated with GLD-1. The sequence information of these regions revealed three over-represented and phylogenetically conserved sequence motifs. We found that two of the motifs, one of which is novel, are important for GLD-1 binding in several GLD-1 binding regions but not in other regions. Further analyses indicate that the importance of one of the sequence motifs is dependent on two aspects: (1) surrounding sequence information, likely acting as an accessory feature for GLD-1 to efficiently select the sequence motif and (2) RNA secondary structural environment where the sequence motif resides, which likely provides “binding-site accessibility” for GLD-1 to effectively recognize its targets. Our data suggest some mRNAs recruit GLD-1 by a distinct mechanism, which involves more than one sequence motif that needs to be embedded in the correct context and structural environment." @default.
• W2033779758 created "2016-06-24" @default.
• W2033779758 creator A5016475473 @default.
• W2033779758 creator A5036910519 @default.
• W2033779758 creator A5077544133 @default.
• W2033779758 creator A5012278769 @default.
• W2033779758 date "2013-10-01" @default.
• W2033779758 modified "2023-09-26" @default.
• W2033779758 title "C. elegansRNA-binding protein GLD-1 recognizes its multiple targets using sequence, context, and structural information to repress translation" @default.
• W2033779758 cites W1488917481 @default.
• W2033779758 cites W1846312500 @default.
• W2033779758 cites W1911220294 @default.
• W2033779758 cites W1954154760 @default.
• W2033779758 cites W1964042787 @default.
• W2033779758 cites W1965267927 @default.
• W2033779758 cites W1965659705 @default.
• W2033779758 cites W1966985603 @default.
• W2033779758 cites W1968934602 @default.
• W2033779758 cites W1974650065 @default.
• W2033779758 cites W1982173655 @default.
• W2033779758 cites W1983011178 @default.
• W2033779758 cites W1988692621 @default.
• W2033779758 cites W1989263240 @default.
• W2033779758 cites W1997953216 @default.
• W2033779758 cites W2000812448 @default.
• W2033779758 cites W2001320847 @default.
• W2033779758 cites W2003787418 @default.
• W2033779758 cites W2013012788 @default.
• W2033779758 cites W2014516971 @default.
• W2033779758 cites W2018548355 @default.
• W2033779758 cites W2026671856 @default.
• W2033779758 cites W2030093783 @default.
• W2033779758 cites W2036378295 @default.
• W2033779758 cites W2036468098 @default.
• W2033779758 cites W2036758739 @default.
• W2033779758 cites W2048663475 @default.
• W2033779758 cites W2050108172 @default.
• W2033779758 cites W2052028890 @default.
• W2033779758 cites W2053003053 @default.
• W2033779758 cites W2059646461 @default.
• W2033779758 cites W2061274891 @default.
• W2033779758 cites W2067020273 @default.
• W2033779758 cites W2067747544 @default.
• W2033779758 cites W2073424121 @default.
• W2033779758 cites W2087345704 @default.
• W2033779758 cites W2087895896 @default.
• W2033779758 cites W2094205892 @default.
• W2033779758 cites W2094232836 @default.
• W2033779758 cites W2099819774 @default.
• W2033779758 cites W2103621333 @default.
• W2033779758 cites W2109074647 @default.
• W2033779758 cites W2111989690 @default.
• W2033779758 cites W2112697630 @default.
• W2033779758 cites W2113978668 @default.
• W2033779758 cites W2114532236 @default.
• W2033779758 cites W2123950820 @default.
• W2033779758 cites W2126690485 @default.
• W2033779758 cites W2128179994 @default.
• W2033779758 cites W2128893980 @default.
• W2033779758 cites W2129160653 @default.
• W2033779758 cites W2129248772 @default.
• W2033779758 cites W2132863465 @default.
• W2033779758 cites W2135221645 @default.
• W2033779758 cites W2138700610 @default.
• W2033779758 cites W2141157874 @default.
• W2033779758 cites W2143087417 @default.
• W2033779758 cites W2147879818 @default.
• W2033779758 cites W2149532470 @default.
• W2033779758 cites W2151101269 @default.
• W2033779758 cites W2154166770 @default.
• W2033779758 cites W2155103279 @default.
• W2033779758 cites W2155967646 @default.
• W2033779758 cites W2157009395 @default.
• W2033779758 cites W4248502863 @default.
• W2033779758 doi "https://doi.org/10.4161/worm.26548" @default.
• W2033779758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3988121" @default.
• W2033779758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24744981" @default.
• W2033779758 hasPublicationYear "2013" @default.
• W2033779758 type Work @default.
• W2033779758 sameAs 2033779758 @default.
• W2033779758 citedByCount "10" @default.
• W2033779758 countsByYear W20337797582013 @default.
• W2033779758 countsByYear W20337797582014 @default.
• W2033779758 countsByYear W20337797582015 @default.
• W2033779758 countsByYear W20337797582016 @default.
• W2033779758 countsByYear W20337797582018 @default.
• W2033779758 countsByYear W20337797582021 @default.
• W2033779758 crossrefType "journal-article" @default.
• W2033779758 hasAuthorship W2033779758A5012278769 @default.
• W2033779758 hasAuthorship W2033779758A5016475473 @default.
• W2033779758 hasAuthorship W2033779758A5036910519 @default.
• W2033779758 hasAuthorship W2033779758A5077544133 @default.
• W2033779758 hasBestOaLocation W20337797581 @default.
• W2033779758 hasConcept C104317684 @default.
• W2033779758 hasConcept C105580179 @default.
• W2033779758 hasConcept C117745874 @default.
• W2033779758 hasConcept C121332964 @default.
• W2033779758 hasConcept C132677234 @default.

• next