Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033801133> ?p ?o ?g. }
- W2033801133 endingPage "374" @default.
- W2033801133 startingPage "366" @default.
- W2033801133 abstract "Alzheimer’s disease (AD) is one of the most common types of progressive dementias. The typical neuropathological changes in AD include extracellular senile plaques, intracellular neurofibrillary tangles, and loss of neurons. The pathogenetic mechanism of this disease is not comprehensively understood yet. Recently, endoplasmic reticulum stress (ER stress) has been considered as a potential event involved in AD development. Some AD-related factors, such as misfolded protein and Ca2+ depletion, could disrupt the homeostasis of ER lumen. In AD, the aggregated amyloid-beta peptide (Abeta) could induce ER stress in an assembly dependent way. The presenilin has been identified as a Ca2+ channel. Mutations of presenilin could change the balance of Ca2+ in ER lumen and thus disrupts the ER homeostasis. Furthermore, the ER stress could lead to cellular disorders like inflammation. Through activating the expression of inflammatory factors, ER stress triggers inflammatory response in AD pathology. Herein, we reviewed the recent progress of ER stress-induced unfolded protein response (UPR) and the roles of ER stress in AD pathological process." @default.
- W2033801133 created "2016-06-24" @default.
- W2033801133 creator A5015505590 @default.
- W2033801133 creator A5022675660 @default.
- W2033801133 creator A5033927639 @default.
- W2033801133 creator A5091150770 @default.
- W2033801133 date "2014-10-13" @default.
- W2033801133 modified "2023-10-15" @default.
- W2033801133 title "Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer’s disease" @default.
- W2033801133 cites W1484463237 @default.
- W2033801133 cites W1502115006 @default.
- W2033801133 cites W1605147833 @default.
- W2033801133 cites W1765185969 @default.
- W2033801133 cites W1821546585 @default.
- W2033801133 cites W1847337270 @default.
- W2033801133 cites W1969071483 @default.
- W2033801133 cites W1975915247 @default.
- W2033801133 cites W1976943917 @default.
- W2033801133 cites W1978582104 @default.
- W2033801133 cites W1978999653 @default.
- W2033801133 cites W1983829653 @default.
- W2033801133 cites W1988499586 @default.
- W2033801133 cites W1990553465 @default.
- W2033801133 cites W1995184566 @default.
- W2033801133 cites W1998026822 @default.
- W2033801133 cites W2006339817 @default.
- W2033801133 cites W2007426180 @default.
- W2033801133 cites W2007970434 @default.
- W2033801133 cites W2010550564 @default.
- W2033801133 cites W2016737975 @default.
- W2033801133 cites W2018269288 @default.
- W2033801133 cites W2027281915 @default.
- W2033801133 cites W2027857376 @default.
- W2033801133 cites W2029422688 @default.
- W2033801133 cites W2031267215 @default.
- W2033801133 cites W2031678297 @default.
- W2033801133 cites W2032419750 @default.
- W2033801133 cites W2033250458 @default.
- W2033801133 cites W2039676434 @default.
- W2033801133 cites W2042551819 @default.
- W2033801133 cites W2044947768 @default.
- W2033801133 cites W2045416582 @default.
- W2033801133 cites W2046503417 @default.
- W2033801133 cites W2058235401 @default.
- W2033801133 cites W2059924886 @default.
- W2033801133 cites W2066418720 @default.
- W2033801133 cites W2073539539 @default.
- W2033801133 cites W2077026981 @default.
- W2033801133 cites W2089185262 @default.
- W2033801133 cites W2089198803 @default.
- W2033801133 cites W2092349079 @default.
- W2033801133 cites W2093025761 @default.
- W2033801133 cites W2094102942 @default.
- W2033801133 cites W2103795148 @default.
- W2033801133 cites W2107301615 @default.
- W2033801133 cites W2108128188 @default.
- W2033801133 cites W2113790633 @default.
- W2033801133 cites W2119811498 @default.
- W2033801133 cites W2124121571 @default.
- W2033801133 cites W2124707930 @default.
- W2033801133 cites W2131954858 @default.
- W2033801133 cites W2135165436 @default.
- W2033801133 cites W2136003325 @default.
- W2033801133 cites W2137662702 @default.
- W2033801133 cites W2141560409 @default.
- W2033801133 cites W2142358502 @default.
- W2033801133 cites W2147502790 @default.
- W2033801133 cites W2147810846 @default.
- W2033801133 cites W2157908301 @default.
- W2033801133 cites W2166508115 @default.
- W2033801133 cites W2166625407 @default.
- W2033801133 cites W2166823635 @default.
- W2033801133 cites W2167500696 @default.
- W2033801133 cites W2167796376 @default.
- W2033801133 cites W2326077285 @default.
- W2033801133 cites W4247759744 @default.
- W2033801133 doi "https://doi.org/10.1179/1743132814y.0000000448" @default.
- W2033801133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25310352" @default.
- W2033801133 hasPublicationYear "2014" @default.
- W2033801133 type Work @default.
- W2033801133 sameAs 2033801133 @default.
- W2033801133 citedByCount "30" @default.
- W2033801133 countsByYear W20338011332014 @default.
- W2033801133 countsByYear W20338011332015 @default.
- W2033801133 countsByYear W20338011332016 @default.
- W2033801133 countsByYear W20338011332017 @default.
- W2033801133 countsByYear W20338011332018 @default.
- W2033801133 countsByYear W20338011332019 @default.
- W2033801133 countsByYear W20338011332020 @default.
- W2033801133 countsByYear W20338011332021 @default.
- W2033801133 countsByYear W20338011332022 @default.
- W2033801133 countsByYear W20338011332023 @default.
- W2033801133 crossrefType "journal-article" @default.
- W2033801133 hasAuthorship W2033801133A5015505590 @default.
- W2033801133 hasAuthorship W2033801133A5022675660 @default.
- W2033801133 hasAuthorship W2033801133A5033927639 @default.
- W2033801133 hasAuthorship W2033801133A5091150770 @default.
- W2033801133 hasConcept C139447449 @default.