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- W2033804901 endingPage "e1098" @default.
- W2033804901 startingPage "e1098" @default.
- W2033804901 abstract "Abstract Acquired resistance toward apoptosis represents one of the hallmarks of human cancer and a major cause of the inefficacy of most anticancer treatment regimens. Based on its ability to inhibit apoptosis, the B-cell lymphoma/leukemia 2 (Bcl-2) protein family has garnered the most attention as a promising therapeutic target in cancer. Accordingly, efforts have lately been focused on the development of drugs targeting Bcl-2 proteins with considerable therapeutic success, particularly in hematologic malignancies. Here, we review the previous studies and highlight the pivotal role of the Bcl-2 protein family in the homeostasis of hematologic tissue compartment. This knowledge provides more insight into why some cancers are more sensitive to Bcl-2 targeting than others and will foster the clinical evaluation of Bcl-2-targeting strategies in cancer by avoiding severe on-target side effects in the development of healthy tissues." @default.
- W2033804901 created "2016-06-24" @default.
- W2033804901 creator A5037873514 @default.
- W2033804901 creator A5051152518 @default.
- W2033804901 date "2014-03-06" @default.
- W2033804901 modified "2023-10-09" @default.
- W2033804901 title "Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?" @default.
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