FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033823376> ?p ?o ?g. }

• W2033823376 endingPage "47" @default.
• W2033823376 startingPage "37" @default.
• W2033823376 abstract "Intracellular microelectrodes were used to record electrically evoked inhibitory junction potentials (IJPs) and electrotonic potentials during spontaneous cyclical depolarisations (myoelectric complexes, MCs) in the circular muscle layer of mouse colon in vitro. In the presence of nifedipine (1-2 microM) and atropine (1 microM), MCs were recorded every 264 +/- 18 s. Between MCs, single electrical stimuli (15 V, 0.6 ms, every 8 s) elicited IJPs whose amplitudes remained constant. In comparison, during the depolarising phase of MCs, the mean IJP amplitude was reduced by 61 +/- 7%, while during the late plateau and early repolarising phase of MCs, IJP amplitude was increased (up to 20%). NG-nitro-L-arginine (NOLA, 100 microM) abolished the repolarisation phase between MCs, so that the circular muscle remained depolarised and the amplitude of MCs was reduced by 73 +/- 6%. However, the amplitude of evoked IJPs was unaffected, as was the decrease in their amplitude during the depolarising phase of the residual MCs. In the presence of NOLA (100 microM), the further addition of apamin (250 nM) reduced the amplitude of evoked IJPs by approximately half. However, the amplitudes of NOLA- and apamin-resistant IJPs were also attenuated by 82 +/- 5% during the depolarising phase of residual MCs (amplitude: 1.9 +/- 1 mV). However, during this phase, the amplitude of an electrotonic potential (evoked by extracellular current application) was not attenuated. Addition of hexamethonium (500 microM), or tetrodotoxin (TTX) (1.6 microM) to solutions containing NOLA and apamin were without effect on membrane potential, but the residual MCs and the cyclical attenuation in IJP amplitude were abolished. During the intervals between MCs, membrane potential is maintained under tonic inhibition, via spontaneous release of inhibitory neurotransmitter(s), predominantly through nitrergic mechanisms. The cyclical attenuation in the amplitude of the non-nitrergic IJP does not arise from cyclical postjunctional changes in membrane resistance or potential. Moreover, the generation of the depolarising phase of MCs involves the simultaneous suppression of both nitrergic and non-nitrergic inhibitory neurotransmission. It is suggested that MCs arise from presynaptic suppression of ongoing inhibitory neurotransmitter release." @default.
• W2033823376 created "2016-06-24" @default.
• W2033823376 creator A5041326163 @default.
• W2033823376 creator A5041392123 @default.
• W2033823376 creator A5066126497 @default.
• W2033823376 date "1998-06-01" @default.
• W2033823376 modified "2023-09-27" @default.
• W2033823376 title "Disinhibition during myoelectric complexes in the mouse colon" @default.
• W2033823376 cites W1789694251 @default.
• W2033823376 cites W1989552243 @default.
• W2033823376 cites W2008326118 @default.
• W2033823376 cites W2012277771 @default.
• W2033823376 cites W2015994586 @default.
• W2033823376 cites W2030899236 @default.
• W2033823376 cites W2037979527 @default.
• W2033823376 cites W2042439021 @default.
• W2033823376 cites W2046771387 @default.
• W2033823376 cites W2047918245 @default.
• W2033823376 cites W2048863801 @default.
• W2033823376 cites W2070716170 @default.
• W2033823376 cites W2078458588 @default.
• W2033823376 cites W2090068233 @default.
• W2033823376 cites W2090689091 @default.
• W2033823376 cites W2099657074 @default.
• W2033823376 cites W2132761800 @default.
• W2033823376 cites W2138621410 @default.
• W2033823376 cites W2152543558 @default.
• W2033823376 cites W2412219209 @default.
• W2033823376 cites W2414660074 @default.
• W2033823376 cites W350322681 @default.
• W2033823376 cites W4301969464 @default.
• W2033823376 doi "https://doi.org/10.1016/s0165-1838(98)00063-0" @default.
• W2033823376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9722193" @default.
• W2033823376 hasPublicationYear "1998" @default.
• W2033823376 type Work @default.
• W2033823376 sameAs 2033823376 @default.
• W2033823376 citedByCount "68" @default.
• W2033823376 countsByYear W20338233762012 @default.
• W2033823376 countsByYear W20338233762013 @default.
• W2033823376 countsByYear W20338233762014 @default.
• W2033823376 countsByYear W20338233762015 @default.
• W2033823376 countsByYear W20338233762016 @default.
• W2033823376 countsByYear W20338233762017 @default.
• W2033823376 countsByYear W20338233762018 @default.
• W2033823376 countsByYear W20338233762019 @default.
• W2033823376 countsByYear W20338233762020 @default.
• W2033823376 countsByYear W20338233762021 @default.
• W2033823376 countsByYear W20338233762022 @default.
• W2033823376 countsByYear W20338233762023 @default.
• W2033823376 crossrefType "journal-article" @default.
• W2033823376 hasAuthorship W2033823376A5041326163 @default.
• W2033823376 hasAuthorship W2033823376A5041392123 @default.
• W2033823376 hasAuthorship W2033823376A5066126497 @default.
• W2033823376 hasConcept C126322002 @default.
• W2033823376 hasConcept C134018914 @default.
• W2033823376 hasConcept C17077164 @default.
• W2033823376 hasConcept C185263204 @default.
• W2033823376 hasConcept C185592680 @default.
• W2033823376 hasConcept C2776741303 @default.
• W2033823376 hasConcept C2776919887 @default.
• W2033823376 hasConcept C71924100 @default.
• W2033823376 hasConcept C83743174 @default.
• W2033823376 hasConcept C86803240 @default.
• W2033823376 hasConceptScore W2033823376C126322002 @default.
• W2033823376 hasConceptScore W2033823376C134018914 @default.
• W2033823376 hasConceptScore W2033823376C17077164 @default.
• W2033823376 hasConceptScore W2033823376C185263204 @default.
• W2033823376 hasConceptScore W2033823376C185592680 @default.
• W2033823376 hasConceptScore W2033823376C2776741303 @default.
• W2033823376 hasConceptScore W2033823376C2776919887 @default.
• W2033823376 hasConceptScore W2033823376C71924100 @default.
• W2033823376 hasConceptScore W2033823376C83743174 @default.
• W2033823376 hasConceptScore W2033823376C86803240 @default.
• W2033823376 hasIssue "1" @default.
• W2033823376 hasLocation W20338233761 @default.
• W2033823376 hasLocation W20338233762 @default.
• W2033823376 hasOpenAccess W2033823376 @default.
• W2033823376 hasPrimaryLocation W20338233761 @default.
• W2033823376 hasRelatedWork W1966504330 @default.
• W2033823376 hasRelatedWork W1979139803 @default.
• W2033823376 hasRelatedWork W2005883099 @default.
• W2033823376 hasRelatedWork W2037631372 @default.
• W2033823376 hasRelatedWork W2040058909 @default.
• W2033823376 hasRelatedWork W2073023698 @default.
• W2033823376 hasRelatedWork W2421189677 @default.
• W2033823376 hasRelatedWork W2748952813 @default.
• W2033823376 hasRelatedWork W2899084033 @default.
• W2033823376 hasRelatedWork W350322681 @default.
• W2033823376 hasVolume "71" @default.
• W2033823376 isParatext "false" @default.
• W2033823376 isRetracted "false" @default.
• W2033823376 magId "2033823376" @default.
• W2033823376 workType "article" @default.