Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033826591> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2033826591 endingPage "644" @default.
- W2033826591 startingPage "627" @default.
- W2033826591 abstract "DNA is prone to structural polymorphism: its three-dimensional structure can differ markedly from the classical double helix. Nucleic acid structures composed of more than two strands have also been observed. The guanine-rich sequence of both the telomere and centromere can form a quadruplex based on G-quartets while the complementary cytosine-rich strand can fold into an intercalated tetramer called the i-motif. The G-quartet is a gold mine for structural biologists and the telomere has become a target for anti-cancer drug design since it was observed that deregulation of telomerase favors proliferation of certain tumors. Other DNA sequences may adopt unusual conformations. Polypurine-polypyrimidine sequences capable of forming a triple-stranded structure called H-DNA are found abundantly in the eukaryotic genome and may play a significant role in DNA metabolism, transcription and replication. Triplex-forming oligonucleotides are currently being developed as anti-gene agents. Unusual DNA structures may therefore be implicated in fundamental processes such as gene expression and represent unique targets for both structural-specific and sequence-specific agents. In this review, we present work characterizing some of these unusual conformations in terms of structure, stability and formation kinetics and discuss their biological implications." @default.
- W2033826591 created "2016-06-24" @default.
- W2033826591 creator A5005575509 @default.
- W2033826591 creator A5027886098 @default.
- W2033826591 creator A5031964935 @default.
- W2033826591 creator A5050656020 @default.
- W2033826591 creator A5050850407 @default.
- W2033826591 creator A5078307757 @default.
- W2033826591 creator A5091689576 @default.
- W2033826591 date "2002-09-01" @default.
- W2033826591 modified "2023-09-25" @default.
- W2033826591 title "Unusual DNA Conformations: Implications for Telomeres" @default.
- W2033826591 doi "https://doi.org/10.2174/1568011023353877" @default.
- W2033826591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12678729" @default.
- W2033826591 hasPublicationYear "2002" @default.
- W2033826591 type Work @default.
- W2033826591 sameAs 2033826591 @default.
- W2033826591 citedByCount "48" @default.
- W2033826591 countsByYear W20338265912012 @default.
- W2033826591 countsByYear W20338265912013 @default.
- W2033826591 countsByYear W20338265912014 @default.
- W2033826591 countsByYear W20338265912015 @default.
- W2033826591 countsByYear W20338265912017 @default.
- W2033826591 countsByYear W20338265912018 @default.
- W2033826591 countsByYear W20338265912019 @default.
- W2033826591 countsByYear W20338265912021 @default.
- W2033826591 countsByYear W20338265912022 @default.
- W2033826591 crossrefType "journal-article" @default.
- W2033826591 hasAuthorship W2033826591A5005575509 @default.
- W2033826591 hasAuthorship W2033826591A5027886098 @default.
- W2033826591 hasAuthorship W2033826591A5031964935 @default.
- W2033826591 hasAuthorship W2033826591A5050656020 @default.
- W2033826591 hasAuthorship W2033826591A5050850407 @default.
- W2033826591 hasAuthorship W2033826591A5078307757 @default.
- W2033826591 hasAuthorship W2033826591A5091689576 @default.
- W2033826591 hasConcept C104317684 @default.
- W2033826591 hasConcept C129312508 @default.
- W2033826591 hasConcept C177336024 @default.
- W2033826591 hasConcept C24107716 @default.
- W2033826591 hasConcept C54355233 @default.
- W2033826591 hasConcept C552990157 @default.
- W2033826591 hasConcept C70721500 @default.
- W2033826591 hasConcept C73573662 @default.
- W2033826591 hasConcept C83762044 @default.
- W2033826591 hasConcept C86803240 @default.
- W2033826591 hasConcept C94581717 @default.
- W2033826591 hasConceptScore W2033826591C104317684 @default.
- W2033826591 hasConceptScore W2033826591C129312508 @default.
- W2033826591 hasConceptScore W2033826591C177336024 @default.
- W2033826591 hasConceptScore W2033826591C24107716 @default.
- W2033826591 hasConceptScore W2033826591C54355233 @default.
- W2033826591 hasConceptScore W2033826591C552990157 @default.
- W2033826591 hasConceptScore W2033826591C70721500 @default.
- W2033826591 hasConceptScore W2033826591C73573662 @default.
- W2033826591 hasConceptScore W2033826591C83762044 @default.
- W2033826591 hasConceptScore W2033826591C86803240 @default.
- W2033826591 hasConceptScore W2033826591C94581717 @default.
- W2033826591 hasIssue "5" @default.
- W2033826591 hasLocation W20338265911 @default.
- W2033826591 hasLocation W20338265912 @default.
- W2033826591 hasOpenAccess W2033826591 @default.
- W2033826591 hasPrimaryLocation W20338265911 @default.
- W2033826591 hasRelatedWork W1964373581 @default.
- W2033826591 hasRelatedWork W1991205530 @default.
- W2033826591 hasRelatedWork W2071030152 @default.
- W2033826591 hasRelatedWork W2071737169 @default.
- W2033826591 hasRelatedWork W2098695343 @default.
- W2033826591 hasRelatedWork W2099067424 @default.
- W2033826591 hasRelatedWork W2358441296 @default.
- W2033826591 hasRelatedWork W2402321437 @default.
- W2033826591 hasRelatedWork W2993010621 @default.
- W2033826591 hasRelatedWork W328243368 @default.
- W2033826591 hasVolume "2" @default.
- W2033826591 isParatext "false" @default.
- W2033826591 isRetracted "false" @default.
- W2033826591 magId "2033826591" @default.
- W2033826591 workType "article" @default.