FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033852098> ?p ?o ?g. }

• W2033852098 endingPage "2144" @default.
• W2033852098 startingPage "2136" @default.
• W2033852098 abstract "This study sought to test the functional exercise capacity and endothelial function in a cohort of chronic heart failure (CHF) patients treated with chronic type 5 phosphodiesterase (PDE5) inhibitor.In CHF, endothelial dysfunction is involved in muscle underperfusion, ergoreflex oversignaling, and exercise ventilation inefficiency. Inhibition of PDE5 by improving endothelial dysfunction might be beneficial.Stable CHF patients were randomly assigned to placebo (23 patients) or sildenafil at the dose of 50 mg twice per day (23 patients) in addition to their current drug treatment for 6 months, with assessments (at 3 and 6 months) of endothelial function by brachial artery flow-mediated dilatation (FMD), cardiopulmonary exercise testing, and ergoreflex response.In the sildenafil group only, at 3 and 6 months we observed reduction of systolic pulmonary artery pressure (from 33.7 to 25.2 mm Hg and 23.9 mm Hg), ergoreflex effect on ventilation (from 6.9 to 2.3 l x min(-1) and 1.9 l x min(-1)), ventilation to CO2 production slope (V(E)/VCO2, from 35.5 to 32.1 and 29.8), and breathlessness (score) (from 23.6 to 16.6 and 17.2), and an increase of FMD (from 8.5% to 13.4% and 14.2%), peak VO2 (from 14.8 to 18.5 ml x min(-1) x kg(-1) and 18.7 ml x min(-1) x kg(-1)), and ratio of VO2 to work rate changes (from 7.7 to 9.3 and 10.1). All changes were significant at p < 0.01. In the sildenafil group, a significant correlation was found at 3 and 6 months between changes in FMD and those in ergoreflex. Changes in ergoreflex correlated with those in peak VO2 and V(E)/VCO2 slope. No adverse effects were noted except for flushing in 3 patients.In CHF, improvement in exercise ventilation and aerobic efficiency with sildenafil is sustained and is significantly related with an endothelium-mediated attenuation of exercising muscle oversignaling. Chronic sildenafil seems to be a remedy based on CHF pathophysiology and devoid of remarkable adverse effects." @default.
• W2033852098 created "2016-06-24" @default.
• W2033852098 creator A5013057215 @default.
• W2033852098 creator A5024847777 @default.
• W2033852098 creator A5035569490 @default.
• W2033852098 creator A5049609430 @default.
• W2033852098 creator A5054371215 @default.
• W2033852098 date "2007-11-01" @default.
• W2033852098 modified "2023-10-01" @default.
• W2033852098 title "Long-Term Use of Sildenafil in the Therapeutic Management of Heart Failure" @default.
• W2033852098 cites W1964061421 @default.
• W2033852098 cites W1972634087 @default.
• W2033852098 cites W1977354362 @default.
• W2033852098 cites W1982601738 @default.
• W2033852098 cites W1985265801 @default.
• W2033852098 cites W1988343956 @default.
• W2033852098 cites W1989228212 @default.
• W2033852098 cites W2007209181 @default.
• W2033852098 cites W2012717896 @default.
• W2033852098 cites W2045033514 @default.
• W2033852098 cites W2045769066 @default.
• W2033852098 cites W2051951308 @default.
• W2033852098 cites W2053775321 @default.
• W2033852098 cites W2061158982 @default.
• W2033852098 cites W2062075871 @default.
• W2033852098 cites W2062678616 @default.
• W2033852098 cites W2063481915 @default.
• W2033852098 cites W2082351345 @default.
• W2033852098 cites W2092761402 @default.
• W2033852098 cites W2105278937 @default.
• W2033852098 cites W2105851379 @default.
• W2033852098 cites W2106045811 @default.
• W2033852098 cites W2106356560 @default.
• W2033852098 cites W2107880459 @default.
• W2033852098 cites W2109723575 @default.
• W2033852098 cites W2114944652 @default.
• W2033852098 cites W2120921534 @default.
• W2033852098 cites W2121376498 @default.
• W2033852098 cites W2122750966 @default.
• W2033852098 cites W2124561899 @default.
• W2033852098 cites W2125142347 @default.
• W2033852098 cites W2132948786 @default.
• W2033852098 cites W2133183012 @default.
• W2033852098 cites W2135720488 @default.
• W2033852098 cites W2147232111 @default.
• W2033852098 cites W2165533293 @default.
• W2033852098 cites W2338144962 @default.
• W2033852098 cites W4244598283 @default.
• W2033852098 doi "https://doi.org/10.1016/j.jacc.2007.07.078" @default.
• W2033852098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18036451" @default.
• W2033852098 hasPublicationYear "2007" @default.
• W2033852098 type Work @default.
• W2033852098 sameAs 2033852098 @default.
• W2033852098 citedByCount "299" @default.
• W2033852098 countsByYear W20338520982012 @default.
• W2033852098 countsByYear W20338520982013 @default.
• W2033852098 countsByYear W20338520982014 @default.
• W2033852098 countsByYear W20338520982015 @default.
• W2033852098 countsByYear W20338520982016 @default.
• W2033852098 countsByYear W20338520982017 @default.
• W2033852098 countsByYear W20338520982018 @default.
• W2033852098 countsByYear W20338520982019 @default.
• W2033852098 countsByYear W20338520982020 @default.
• W2033852098 countsByYear W20338520982021 @default.
• W2033852098 countsByYear W20338520982022 @default.
• W2033852098 countsByYear W20338520982023 @default.
• W2033852098 crossrefType "journal-article" @default.
• W2033852098 hasAuthorship W2033852098A5013057215 @default.
• W2033852098 hasAuthorship W2033852098A5024847777 @default.
• W2033852098 hasAuthorship W2033852098A5035569490 @default.
• W2033852098 hasAuthorship W2033852098A5049609430 @default.
• W2033852098 hasAuthorship W2033852098A5054371215 @default.
• W2033852098 hasBestOaLocation W20338520981 @default.
• W2033852098 hasConcept C126322002 @default.
• W2033852098 hasConcept C142724271 @default.
• W2033852098 hasConcept C164705383 @default.
• W2033852098 hasConcept C204787440 @default.
• W2033852098 hasConcept C27081682 @default.
• W2033852098 hasConcept C2776768464 @default.
• W2033852098 hasConcept C2777604165 @default.
• W2033852098 hasConcept C2778198053 @default.
• W2033852098 hasConcept C2780972559 @default.
• W2033852098 hasConcept C42219234 @default.
• W2033852098 hasConcept C71924100 @default.
• W2033852098 hasConcept C84393581 @default.
• W2033852098 hasConceptScore W2033852098C126322002 @default.
• W2033852098 hasConceptScore W2033852098C142724271 @default.
• W2033852098 hasConceptScore W2033852098C164705383 @default.
• W2033852098 hasConceptScore W2033852098C204787440 @default.
• W2033852098 hasConceptScore W2033852098C27081682 @default.
• W2033852098 hasConceptScore W2033852098C2776768464 @default.
• W2033852098 hasConceptScore W2033852098C2777604165 @default.
• W2033852098 hasConceptScore W2033852098C2778198053 @default.
• W2033852098 hasConceptScore W2033852098C2780972559 @default.
• W2033852098 hasConceptScore W2033852098C42219234 @default.
• W2033852098 hasConceptScore W2033852098C71924100 @default.
• W2033852098 hasConceptScore W2033852098C84393581 @default.
• W2033852098 hasIssue "22" @default.

• next