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- W2033854478 abstract "Human platelets, prelabeled with [32P]phospate were treated with tetradecanoylphorbol acetate (TPA) for 5 min at 37°C. Phosphorylation of the components of adenylyl cyclase was determined in membranes using specific antibodies against G-proteins and the catalytic moiety. Less than 0.01 mol of [32P]phosphate/mol could be detected in immunoprecipitates using antibodies against sequences within the α-subunit of the GTP binding protein Gi. TPA, however, caused the incorporation of 0.67–1.1 mol of [32P]phosphate per mol of catalyst while 0.13-0.2 mol were found in the absence or TPA. Lack of modification of the α-subunit of Gi was also indicated by the results of reconstitution experiments with purified Giα from bovine brain: adenylyl cyclase in membranes from untreated platelets was significantly more inhibited by added Giα, than that from TPA treated cells. While β,γ-subunits were like-wise inhibitory no difference dependent on platelet-pretreatment could be observed." @default.
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- W2033854478 date "1991-07-08" @default.
- W2033854478 modified "2023-09-26" @default.
- W2033854478 title "Chemical and functional analysis of components of adenylyl cyclase from human platelets treated with phorbolesters" @default.
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- W2033854478 doi "https://doi.org/10.1016/0014-5793(91)80734-k" @default.
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