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- W2033854520 endingPage "2033" @default.
- W2033854520 startingPage "2025" @default.
- W2033854520 abstract "Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, differentiation and activity; however, not all of their functions are clear. Enamel extracts have been proposed to have numerous activities such as bone morphogenetic protein‑ and transforming growth factor β (TGF‑β)‑like activity, and activities similar to those of insulin‑like growth factor, fibroblast growth factor, platelet‑derived growth factor, vascular endothelial growth factor and epidermal growth factor. These activities have been observed at the molecular and cellular levels and in numerous animal models. Furthermore, it has been suggested that EMD contains an unidentified biologically active factor that acts in combination with TGF‑β1, and several studies have reported functional similarities between growth factors and TGF‑β in cellular processes. The effects of enamel extracts on the cell cycle and biology are summarized and discussed in this review." @default.
- W2033854520 created "2016-06-24" @default.
- W2033854520 creator A5001873535 @default.
- W2033854520 creator A5028029402 @default.
- W2033854520 creator A5072220304 @default.
- W2033854520 creator A5079636370 @default.
- W2033854520 creator A5090929315 @default.
- W2033854520 date "2015-04-07" @default.
- W2033854520 modified "2023-09-27" @default.
- W2033854520 title "Enamel matrix proteins exhibit growth factor activity: A review of evidence at the cellular and molecular levels" @default.
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