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- W2033855538 abstract "Nanopore analysis holds great promise for performing DNA footprinting, wherein the locations of binding entities can be mapped along single molecules to reveal substructure. Towards this goal, we describe progress in the use of solid-state nanopores for the detection of sequence-specific proteins bound to double-strand DNA. We detect multiple specific binding entities during translocation using a common current sensing technique. We further investigate custom molecular constructs that offer single protein binding sites as a model system. Successful implementation of this measurement technique has implications for future use in rapid genetic and epigenetic diagnostic systems." @default.
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- W2033855538 date "2013-01-01" @default.
- W2033855538 modified "2023-09-27" @default.
- W2033855538 title "Detection of Sequence-Specific Proteins Bound to DNA using Solid-State Nanopores" @default.
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- W2033855538 doi "https://doi.org/10.1016/j.bpj.2012.11.2862" @default.
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