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• W2033860215 abstract "The aim of this study was to prepare by melt agglomeration agglomerates containing solid dispersions of diazepam as poorly water-soluble model drug in order to evaluate the possibility of improving the dissolution rate. Lactose monohydrate was melt agglomerated with polyethylene glycol (PEG) 3000 or Gelucire 50/13 (mixture of glycerides and PEG esters of fatty acids) as meltable binders in a high shear mixer. The binders were added either as a mixture of melted binder and diazepam by a pump-on procedure or by a melt-in procedure of solid binder particles. Different drug concentrations, maximum manufacturing temperatures, and cooling rates were investigated. It was found to be possible to increase the dissolution rate of diazepam by melt agglomeration. A higher dissolution rate was obtained with a lower drug concentration. Admixing the binders by the melt-in procedure resulted in similar dissolution rates as the pump-on procedure. The different maximum manufacturing temperatures and cooling rates were found to have complex effects on the dissolution rate for formulations containing PEG 3000, whereas only minor effects of the cooling procedure were found with Gelucire 50/13. Gelucire 50/13 resulted in faster dissolution rates compared to PEG 3000." @default.
• W2033860215 created "2016-06-24" @default.
• W2033860215 creator A5026086652 @default.
• W2033860215 date "2003-06-18" @default.
• W2033860215 modified "2023-09-23" @default.
• W2033860215 title "The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer" @default.
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• W2033860215 doi "https://doi.org/10.1016/s0378-5173(03)00228-x" @default.
• W2033860215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12787644" @default.
• W2033860215 hasPublicationYear "2003" @default.
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