FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033862008> ?p ?o ?g. }

• W2033862008 endingPage "49" @default.
• W2033862008 startingPage "39" @default.
• W2033862008 abstract "An understanding of details of the interaction mechanisms of bacterial endotoxins (lipopolysaccharide, LPS) with the oxygen transport protein hemoglobin is still lacking, despite its high biological relevance. Here, a biophysical investigation into the endotoxin:hemoglobin interaction is presented which comprises the use of various rough mutant LPS as well as free lipid A; in addition to the complete hemoglobin molecule from fetal sheep extract, also the partial structure α-chain and the heme-free sample are studied. The investigations comprise the determination of the gel-to-liquid crystalline phase behaviour of the acyl chains of LPS, the ultrastructure (type of aggregate structure and morphology) of the endotoxins, and the incorporation of the hemoglobins into artificial immune cell membranes and into LPS. Our data suggest a model for the interaction between Hb and LPS in which hemoglobins do not react strongly with the hydrophilic or with the hydrophobic moiety of LPS, but with the complete endotoxin aggregate. Hb is able to incorporate into LPS with the longitudinal direction parallel to the lipid A double-layer. Although this does not lead to a strong disturbance of the LPS acyl chain packing, the change of the curvature leads to a slightly conical molecular shape with a change of the three-dimensional arrangement from unilamellar into cubic LPS aggregates. Our previous results show that cubic LPS structures exhibit strong endotoxic activity. The property of Hb on the physical state of LPS described here may explain the observation of an increase in LPS-mediating endotoxicity due to the action of Hb." @default.
• W2033862008 created "2016-06-24" @default.
• W2033862008 creator A5002372529 @default.
• W2033862008 creator A5008497291 @default.
• W2033862008 creator A5013168738 @default.
• W2033862008 creator A5019912293 @default.
• W2033862008 creator A5019943798 @default.
• W2033862008 creator A5022814723 @default.
• W2033862008 creator A5035937335 @default.
• W2033862008 creator A5042228448 @default.
• W2033862008 creator A5055069040 @default.
• W2033862008 creator A5069691156 @default.
• W2033862008 creator A5071091256 @default.
• W2033862008 creator A5089396932 @default.
• W2033862008 creator A5090073823 @default.
• W2033862008 creator A5090327349 @default.
• W2033862008 date "2008-02-01" @default.
• W2033862008 modified "2023-10-17" @default.
• W2033862008 title "Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins" @default.
• W2033862008 cites W1490235594 @default.
• W2033862008 cites W1530578004 @default.
• W2033862008 cites W1565080352 @default.
• W2033862008 cites W1572279530 @default.
• W2033862008 cites W1820877372 @default.
• W2033862008 cites W1866771879 @default.
• W2033862008 cites W1964434412 @default.
• W2033862008 cites W1966477801 @default.
• W2033862008 cites W1975922282 @default.
• W2033862008 cites W1979381676 @default.
• W2033862008 cites W1981586536 @default.
• W2033862008 cites W1984902956 @default.
• W2033862008 cites W1987450040 @default.
• W2033862008 cites W1993106535 @default.
• W2033862008 cites W2000307270 @default.
• W2033862008 cites W2000951822 @default.
• W2033862008 cites W2010982832 @default.
• W2033862008 cites W2011683499 @default.
• W2033862008 cites W2055198172 @default.
• W2033862008 cites W2064901683 @default.
• W2033862008 cites W2099317173 @default.
• W2033862008 cites W2104880716 @default.
• W2033862008 cites W2146948320 @default.
• W2033862008 cites W2147672878 @default.
• W2033862008 cites W2161533700 @default.
• W2033862008 cites W2163399401 @default.
• W2033862008 cites W2413324144 @default.
• W2033862008 cites W3022057079 @default.
• W2033862008 cites W51509219 @default.
• W2033862008 doi "https://doi.org/10.1177/1753425907087257" @default.
• W2033862008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18387918" @default.
• W2033862008 hasPublicationYear "2008" @default.
• W2033862008 type Work @default.
• W2033862008 sameAs 2033862008 @default.
• W2033862008 citedByCount "15" @default.
• W2033862008 countsByYear W20338620082012 @default.
• W2033862008 countsByYear W20338620082013 @default.
• W2033862008 countsByYear W20338620082014 @default.
• W2033862008 countsByYear W20338620082016 @default.
• W2033862008 countsByYear W20338620082017 @default.
• W2033862008 countsByYear W20338620082022 @default.
• W2033862008 crossrefType "journal-article" @default.
• W2033862008 hasAuthorship W2033862008A5002372529 @default.
• W2033862008 hasAuthorship W2033862008A5008497291 @default.
• W2033862008 hasAuthorship W2033862008A5013168738 @default.
• W2033862008 hasAuthorship W2033862008A5019912293 @default.
• W2033862008 hasAuthorship W2033862008A5019943798 @default.
• W2033862008 hasAuthorship W2033862008A5022814723 @default.
• W2033862008 hasAuthorship W2033862008A5035937335 @default.
• W2033862008 hasAuthorship W2033862008A5042228448 @default.
• W2033862008 hasAuthorship W2033862008A5055069040 @default.
• W2033862008 hasAuthorship W2033862008A5069691156 @default.
• W2033862008 hasAuthorship W2033862008A5071091256 @default.
• W2033862008 hasAuthorship W2033862008A5089396932 @default.
• W2033862008 hasAuthorship W2033862008A5090073823 @default.
• W2033862008 hasAuthorship W2033862008A5090327349 @default.
• W2033862008 hasBestOaLocation W20338620081 @default.
• W2033862008 hasConcept C104317684 @default.
• W2033862008 hasConcept C11268172 @default.
• W2033862008 hasConcept C12554922 @default.
• W2033862008 hasConcept C134018914 @default.
• W2033862008 hasConcept C143065580 @default.
• W2033862008 hasConcept C144464004 @default.
• W2033862008 hasConcept C146587185 @default.
• W2033862008 hasConcept C147789679 @default.
• W2033862008 hasConcept C181199279 @default.
• W2033862008 hasConcept C184651966 @default.
• W2033862008 hasConcept C185592680 @default.
• W2033862008 hasConcept C2776217839 @default.
• W2033862008 hasConcept C2776621215 @default.
• W2033862008 hasConcept C2778754761 @default.
• W2033862008 hasConcept C2778917026 @default.
• W2033862008 hasConcept C41625074 @default.
• W2033862008 hasConcept C547475151 @default.
• W2033862008 hasConcept C55493867 @default.
• W2033862008 hasConcept C86803240 @default.
• W2033862008 hasConceptScore W2033862008C104317684 @default.
• W2033862008 hasConceptScore W2033862008C11268172 @default.
• W2033862008 hasConceptScore W2033862008C12554922 @default.

• next