Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033865710> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2033865710 endingPage "4505" @default.
- W2033865710 startingPage "4502" @default.
- W2033865710 abstract "The design and synthesis of indazolinone containing kinase inhibitors are reported. Regioisomers that showed profound potency variation in previously-reported isoindolinone and aminoindazole systems were surprisingly found to have similar potencies in the case of the indazolinone chemical series. An interpretation using differential hinge hydrogen bonding and tautomeric equilibrium of indazolinone ring system is supported by quantum mechanics calculations. The equipotent inhibition of a representative kinase (KDR) by regioisomeric indazolinones 4 and 5 is clear evidence that in case of the indazolinone hinge, both tautomers are equally favored, and should be considered in design of inhibitors." @default.
- W2033865710 created "2016-06-24" @default.
- W2033865710 creator A5005529926 @default.
- W2033865710 creator A5006402261 @default.
- W2033865710 creator A5012619985 @default.
- W2033865710 creator A5014487006 @default.
- W2033865710 creator A5031696055 @default.
- W2033865710 creator A5044440916 @default.
- W2033865710 creator A5044826327 @default.
- W2033865710 date "2012-07-01" @default.
- W2033865710 modified "2023-09-23" @default.
- W2033865710 title "Contribution of indazolinone tautomers to kinase activity" @default.
- W2033865710 cites W2007604505 @default.
- W2033865710 cites W2017808402 @default.
- W2033865710 cites W2031498310 @default.
- W2033865710 cites W2034336270 @default.
- W2033865710 cites W2086979769 @default.
- W2033865710 cites W2096849227 @default.
- W2033865710 cites W2180938914 @default.
- W2033865710 doi "https://doi.org/10.1016/j.bmcl.2012.06.009" @default.
- W2033865710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22738639" @default.
- W2033865710 hasPublicationYear "2012" @default.
- W2033865710 type Work @default.
- W2033865710 sameAs 2033865710 @default.
- W2033865710 citedByCount "1" @default.
- W2033865710 countsByYear W20338657102014 @default.
- W2033865710 crossrefType "journal-article" @default.
- W2033865710 hasAuthorship W2033865710A5005529926 @default.
- W2033865710 hasAuthorship W2033865710A5006402261 @default.
- W2033865710 hasAuthorship W2033865710A5012619985 @default.
- W2033865710 hasAuthorship W2033865710A5014487006 @default.
- W2033865710 hasAuthorship W2033865710A5031696055 @default.
- W2033865710 hasAuthorship W2033865710A5044440916 @default.
- W2033865710 hasAuthorship W2033865710A5044826327 @default.
- W2033865710 hasConcept C111233374 @default.
- W2033865710 hasConcept C112887158 @default.
- W2033865710 hasConcept C147597530 @default.
- W2033865710 hasConcept C178790620 @default.
- W2033865710 hasConcept C184235292 @default.
- W2033865710 hasConcept C185592680 @default.
- W2033865710 hasConcept C202235601 @default.
- W2033865710 hasConcept C2780378348 @default.
- W2033865710 hasConcept C2991951333 @default.
- W2033865710 hasConcept C32909587 @default.
- W2033865710 hasConcept C55493867 @default.
- W2033865710 hasConcept C71240020 @default.
- W2033865710 hasConceptScore W2033865710C111233374 @default.
- W2033865710 hasConceptScore W2033865710C112887158 @default.
- W2033865710 hasConceptScore W2033865710C147597530 @default.
- W2033865710 hasConceptScore W2033865710C178790620 @default.
- W2033865710 hasConceptScore W2033865710C184235292 @default.
- W2033865710 hasConceptScore W2033865710C185592680 @default.
- W2033865710 hasConceptScore W2033865710C202235601 @default.
- W2033865710 hasConceptScore W2033865710C2780378348 @default.
- W2033865710 hasConceptScore W2033865710C2991951333 @default.
- W2033865710 hasConceptScore W2033865710C32909587 @default.
- W2033865710 hasConceptScore W2033865710C55493867 @default.
- W2033865710 hasConceptScore W2033865710C71240020 @default.
- W2033865710 hasIssue "14" @default.
- W2033865710 hasLocation W20338657101 @default.
- W2033865710 hasLocation W20338657102 @default.
- W2033865710 hasOpenAccess W2033865710 @default.
- W2033865710 hasPrimaryLocation W20338657101 @default.
- W2033865710 hasRelatedWork W1872872970 @default.
- W2033865710 hasRelatedWork W1953541549 @default.
- W2033865710 hasRelatedWork W1966980303 @default.
- W2033865710 hasRelatedWork W1982344229 @default.
- W2033865710 hasRelatedWork W2323091514 @default.
- W2033865710 hasRelatedWork W2323175946 @default.
- W2033865710 hasRelatedWork W2398612775 @default.
- W2033865710 hasRelatedWork W2951398945 @default.
- W2033865710 hasRelatedWork W3048604546 @default.
- W2033865710 hasRelatedWork W3083615080 @default.
- W2033865710 hasVolume "22" @default.
- W2033865710 isParatext "false" @default.
- W2033865710 isRetracted "false" @default.
- W2033865710 magId "2033865710" @default.
- W2033865710 workType "article" @default.