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- W2033868413 abstract "A new inhibitor against disease-related enzymes, collagenase, hyaluronidase, and xanthine oxidase, has been developed by the laccase-catalyzed conjugation of catechin on poly(ε-lysine). The resulting poly(ε-lysine)−catechin conjugate showed greatly improved inhibition effects on activity of these enzymes, whereas the catechin monomer showed very low inhibition activity. The kinetic analysis on the inhibition of collagenase exhibited that the conjugate was a mixed-type inhibitor. The amplified activities might offer high potential as a therapeutic agent for prevention of various enzyme-related diseases." @default.
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- W2033868413 date "2004-08-04" @default.
- W2033868413 modified "2023-10-03" @default.
- W2033868413 title "Amplification of Inhibitory Activity of Catechin against Disease-Related Enzymes by Conjugation on Poly(ε-lysine)" @default.
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- W2033868413 doi "https://doi.org/10.1021/bm049823x" @default.
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