FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033869275> ?p ?o ?g. }

• W2033869275 endingPage "695" @default.
• W2033869275 startingPage "682" @default.
• W2033869275 abstract "Khat (Catha edulis) is an evergreen tree/shrub that is thought to affect sexual motivation or libido. Its positive effect on sexual desire is more frequently observed in females than in males and occurs when khat is chewed. Thus, khat's effects on sexual behavior may depend on the release mode of its active constituent.This study aimed to investigate the effect of dried khat alkaloids on the sexual motivation and estradiol levels of female rats, with special emphasis on the importance of the sustained release effect.Dried khat leaves were extracted and isolated. The alkaloids in khat extract were identified and calculated using thin layer chromatography and high-performance liquid chromatography. The isolated khat extract was microencapsulated using a phase separation coacervation method. The morphology, particle size, yield, drug loading, and entrapment efficiency were evaluated. The in vitro release and stability of alkaloids in khat extract and in khat extract microcapsules were determined. The effect of khat extract microcapsules and varying doses of khat extract on sexual motivation in female rats were investigated. Additionally, estradiol levels, vaginal secretions and vaginal pH were determined.The differences in the effect of khat extract and khat extract microcapsules on sexual motivation, vaginal secretion and estradiol levels in female rats were compared. Results. Cathine and norephedrine were identified in the isolated khat extract at composition of 81.3% and 17.2%, respectively. Among the formulations studied, khat extract microcapsules of formulation 2:3:5 (containing a ratio of khat extract to ovalbumin to gelatin of 2:3:5) were found to exhibit higher yield, loading, and entrapment efficiency. Khat extract microcapsules showed sustained in vitro release and were more stable than khat extract. In addition, khat extract microcapsules enhanced sexual motivation, increased vaginal secretions, and upregulated estradiol level in female rats.The sustained release of alkaloids from dried khat has significantly enhanced the sexual motivation and increased the estradiol level of female rats. Thus the release of dried khat alkaloids from microcapsules might be an effective means of enhancing the libido in females." @default.
• W2033869275 created "2016-06-24" @default.
• W2033869275 creator A5009079233 @default.
• W2033869275 creator A5052397987 @default.
• W2033869275 creator A5067094080 @default.
• W2033869275 date "2009-03-01" @default.
• W2033869275 modified "2023-09-27" @default.
• W2033869275 title "Extraction and Microencapsulation of Khat: Effects on Sexual Motivation and Estradiol Level in Female Rats" @default.
• W2033869275 cites W1495421425 @default.
• W2033869275 cites W1514817670 @default.
• W2033869275 cites W1515090561 @default.
• W2033869275 cites W1549619776 @default.
• W2033869275 cites W1747161056 @default.
• W2033869275 cites W1963966682 @default.
• W2033869275 cites W1963984655 @default.
• W2033869275 cites W1972299636 @default.
• W2033869275 cites W1973248802 @default.
• W2033869275 cites W1974643121 @default.
• W2033869275 cites W1976321605 @default.
• W2033869275 cites W1978413959 @default.
• W2033869275 cites W1981656359 @default.
• W2033869275 cites W1987995635 @default.
• W2033869275 cites W1993112064 @default.
• W2033869275 cites W1999925128 @default.
• W2033869275 cites W2000463633 @default.
• W2033869275 cites W2005163322 @default.
• W2033869275 cites W2005249121 @default.
• W2033869275 cites W2007101824 @default.
• W2033869275 cites W2011115123 @default.
• W2033869275 cites W2011115854 @default.
• W2033869275 cites W2011834815 @default.
• W2033869275 cites W2014573072 @default.
• W2033869275 cites W2015279743 @default.
• W2033869275 cites W2025993388 @default.
• W2033869275 cites W2031861087 @default.
• W2033869275 cites W2036862760 @default.
• W2033869275 cites W2037394228 @default.
• W2033869275 cites W2038467744 @default.
• W2033869275 cites W2039060523 @default.
• W2033869275 cites W2043828859 @default.
• W2033869275 cites W2044381164 @default.
• W2033869275 cites W2045105204 @default.
• W2033869275 cites W2050774429 @default.
• W2033869275 cites W2055680435 @default.
• W2033869275 cites W2057313063 @default.
• W2033869275 cites W2058671113 @default.
• W2033869275 cites W2061696705 @default.
• W2033869275 cites W2064440181 @default.
• W2033869275 cites W2067753073 @default.
• W2033869275 cites W2074313055 @default.
• W2033869275 cites W2076388232 @default.
• W2033869275 cites W2076770308 @default.
• W2033869275 cites W2078857839 @default.
• W2033869275 cites W2079727968 @default.
• W2033869275 cites W2083773032 @default.
• W2033869275 cites W2085689996 @default.
• W2033869275 cites W2090467134 @default.
• W2033869275 cites W2090837608 @default.
• W2033869275 cites W20993284 @default.
• W2033869275 cites W2108273636 @default.
• W2033869275 cites W2111145301 @default.
• W2033869275 cites W2111227773 @default.
• W2033869275 cites W2111923270 @default.
• W2033869275 cites W2124671775 @default.
• W2033869275 cites W2125309442 @default.
• W2033869275 cites W2127561636 @default.
• W2033869275 cites W2128560430 @default.
• W2033869275 cites W2131519759 @default.
• W2033869275 cites W2134165690 @default.
• W2033869275 cites W2135423203 @default.
• W2033869275 cites W2136707925 @default.
• W2033869275 cites W2136748748 @default.
• W2033869275 cites W2143152699 @default.
• W2033869275 cites W2149832719 @default.
• W2033869275 cites W2152309097 @default.
• W2033869275 cites W2152767999 @default.
• W2033869275 cites W2157411845 @default.
• W2033869275 cites W2162042648 @default.
• W2033869275 cites W2170614475 @default.
• W2033869275 cites W2172036001 @default.
• W2033869275 cites W2313868936 @default.
• W2033869275 cites W4244728283 @default.
• W2033869275 cites W2017629531 @default.
• W2033869275 doi "https://doi.org/10.1111/j.1743-6109.2008.01157.x" @default.
• W2033869275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19143913" @default.
• W2033869275 hasPublicationYear "2009" @default.
• W2033869275 type Work @default.
• W2033869275 sameAs 2033869275 @default.
• W2033869275 citedByCount "13" @default.
• W2033869275 countsByYear W20338692752012 @default.
• W2033869275 countsByYear W20338692752013 @default.
• W2033869275 countsByYear W20338692752015 @default.
• W2033869275 countsByYear W20338692752017 @default.
• W2033869275 countsByYear W20338692752020 @default.
• W2033869275 countsByYear W20338692752021 @default.
• W2033869275 crossrefType "journal-article" @default.
• W2033869275 hasAuthorship W2033869275A5009079233 @default.
• W2033869275 hasAuthorship W2033869275A5052397987 @default.

• next