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- W2033908049 abstract "Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides ( dilps ) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated by up-regulation of the Drosophila FOXO (dFOXO) target genes 4E-BP and l ( 2 ) efl and the insulin/IGF-binding protein IMP-L2 . These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved." @default.
- W2033908049 created "2016-06-24" @default.
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- W2033908049 date "2008-04-29" @default.
- W2033908049 modified "2023-10-13" @default.
- W2033908049 title "<i>Drosophila</i> germ-line modulation of insulin signaling and lifespan" @default.
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- W2033908049 doi "https://doi.org/10.1073/pnas.0709128105" @default.
- W2033908049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2359818" @default.
- W2033908049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18434551" @default.
- W2033908049 hasPublicationYear "2008" @default.
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