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- W2033920804 abstract "Microglia, major immune effector cells in the central nervous system, become activated during brain injury. In this study we showed that the blood component plasminogen/plasmin activates microglia. Plasminogen-induced IL-1beta, TNF-alpha, and iNOS mRNA expression in primary cultured rat microglia and BV2 murine microglial cells. Plasmin caused a similar response. Serine protease inhibitors suppressed both plasminogen- and plasmin-induced IL-1beta and TNF-alpha expression, indicating the importance of serine protease activity in plasminogen/plasmin activation of microglia. Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. Furthermore, plasminogen stimulated CREB and NF-kappaB DNA binding activity, and this activation was also reduced by trolox and NAC. These results suggest that plasminogen activates microglia via stimulation of ROS production." @default.
- W2033920804 created "2016-06-24" @default.
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- W2033920804 date "2003-12-01" @default.
- W2033920804 modified "2023-10-12" @default.
- W2033920804 title "Plasminogen-induced IL-1β and TNF-α production in microglia is regulated by reactive oxygen species" @default.
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- W2033920804 doi "https://doi.org/10.1016/j.bbrc.2003.11.010" @default.
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