Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033940602> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2033940602 endingPage "392" @default.
- W2033940602 startingPage "388" @default.
- W2033940602 abstract "A quantitative and selective method has been developed for the determination of a novel local anaesthetic compound pentacaine, trans-2-(1-pyrrolidinyl)cyclohexyl-3-pentyloxycarbanilate hydrochloride, in biological samples. After ion pair extraction from 1 M HCl into 1,2-dichloroethane, pentacaine and a structurally related internal standard were derivatized to prevent thermal decomposition in the gas chromatograph. An on-column methylation technique with trimethylanilinium hydroxide was used. Determination was performed by gas chromatography/mass spectrometry (GC/MS) with selected ion monitoring. Interferences by endogenous lipophilic constituents were avoided by including an n-hexane wash before the ion pair extraction. This wash step did not reduce the drug recoveries. The method gave linear results over a concentration range of 5-100 ng ml−1 with a coefficient of variation less than 10% at 5 ng pentacaine ml−1. Specimens of plasma, whole blood, urine as well as in vitro preparations such as hepatic microsomes were successfully analysed." @default.
- W2033940602 created "2016-06-24" @default.
- W2033940602 creator A5057473936 @default.
- W2033940602 creator A5074770955 @default.
- W2033940602 creator A5090033850 @default.
- W2033940602 date "1985-08-01" @default.
- W2033940602 modified "2023-10-18" @default.
- W2033940602 title "Determination of pentacaine, trans-2-(1-pyrrolidinyl)cyclohexyl-3-pentyloxycarbanilate hydrochloride, in biological samples by gas chromatography/mass spectrometry" @default.
- W2033940602 cites W1970700397 @default.
- W2033940602 cites W1976190161 @default.
- W2033940602 cites W2065915078 @default.
- W2033940602 doi "https://doi.org/10.1002/bms.1200120806" @default.
- W2033940602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2931128" @default.
- W2033940602 hasPublicationYear "1985" @default.
- W2033940602 type Work @default.
- W2033940602 sameAs 2033940602 @default.
- W2033940602 citedByCount "2" @default.
- W2033940602 crossrefType "journal-article" @default.
- W2033940602 hasAuthorship W2033940602A5057473936 @default.
- W2033940602 hasAuthorship W2033940602A5074770955 @default.
- W2033940602 hasAuthorship W2033940602A5090033850 @default.
- W2033940602 hasConcept C123460561 @default.
- W2033940602 hasConcept C162356407 @default.
- W2033940602 hasConcept C178790620 @default.
- W2033940602 hasConcept C179302884 @default.
- W2033940602 hasConcept C185592680 @default.
- W2033940602 hasConcept C205345274 @default.
- W2033940602 hasConcept C2776460385 @default.
- W2033940602 hasConcept C2777077568 @default.
- W2033940602 hasConcept C43617362 @default.
- W2033940602 hasConcept C4725764 @default.
- W2033940602 hasConceptScore W2033940602C123460561 @default.
- W2033940602 hasConceptScore W2033940602C162356407 @default.
- W2033940602 hasConceptScore W2033940602C178790620 @default.
- W2033940602 hasConceptScore W2033940602C179302884 @default.
- W2033940602 hasConceptScore W2033940602C185592680 @default.
- W2033940602 hasConceptScore W2033940602C205345274 @default.
- W2033940602 hasConceptScore W2033940602C2776460385 @default.
- W2033940602 hasConceptScore W2033940602C2777077568 @default.
- W2033940602 hasConceptScore W2033940602C43617362 @default.
- W2033940602 hasConceptScore W2033940602C4725764 @default.
- W2033940602 hasIssue "8" @default.
- W2033940602 hasLocation W20339406021 @default.
- W2033940602 hasLocation W20339406022 @default.
- W2033940602 hasOpenAccess W2033940602 @default.
- W2033940602 hasPrimaryLocation W20339406021 @default.
- W2033940602 hasRelatedWork W1981976271 @default.
- W2033940602 hasRelatedWork W1991134895 @default.
- W2033940602 hasRelatedWork W1992714963 @default.
- W2033940602 hasRelatedWork W2033413454 @default.
- W2033940602 hasRelatedWork W2033940602 @default.
- W2033940602 hasRelatedWork W2047511728 @default.
- W2033940602 hasRelatedWork W2079996778 @default.
- W2033940602 hasRelatedWork W2081925920 @default.
- W2033940602 hasRelatedWork W2092817559 @default.
- W2033940602 hasRelatedWork W2096652817 @default.
- W2033940602 hasVolume "12" @default.
- W2033940602 isParatext "false" @default.
- W2033940602 isRetracted "false" @default.
- W2033940602 magId "2033940602" @default.
- W2033940602 workType "article" @default.