FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033969179> ?p ?o ?g. }

• W2033969179 endingPage "1149" @default.
• W2033969179 startingPage "1142" @default.
• W2033969179 abstract "Although α-nucleosides are not found in nucleic acid, they do occur as constituents of smaller molecules in living cells, e.g., in vitamin B12. There are now several examples of α-nucleosides exerting a biological activity in some instances equal to, or even exceeding, that of the corresponding β-anomer. Examples include growth inhibitory properties against mouse leukemia cells and antitumor activity. From stereochemical point of view, α-anomers serve as references for studying of interaction of the base with the sugar moiety in β-anomers and may help in better understanding of structure–activity relationships. One important problem preventing conformational analysis of α nucleosides is uncertainty in the determination of vicinal coupling constants from simulation of overlapping sugar proton resonances of strongly coupled spin systems. A successful resolution of near-isochronous H3′ and H4′ resonances made possible a full conformational analysis for a series of α-anomers C5-substituted 2′-deoxyuridines, including methyl, ethyl, isopropyl, fluor, vinyl, and bromovinyl, in comparison to their β counterparts. Conformation of the sugar ring is determined from proton–proton coupling constants and described in terms of pseudorotation between two main puckering domains C2′endo (S) and C3′endo (N). A thorough analysis of chemical shifts as well as conformation of the sugar ring and C4′–C5′ rotamers made possible determination of conformational preferences in equilibrium about the glycosidic bond between two regions, anti and syn. This work provides insights into the role of anomeric configuration of the base in conformational behavior of the sugar moiety, a link in the backbone of nucleic acids." @default.
• W2033969179 created "2016-06-24" @default.
• W2033969179 creator A5001493896 @default.
• W2033969179 creator A5010360036 @default.
• W2033969179 creator A5029050926 @default.
• W2033969179 creator A5062372955 @default.
• W2033969179 creator A5079985617 @default.
• W2033969179 date "2001-05-01" @default.
• W2033969179 modified "2023-09-28" @default.
• W2033969179 title "1H NMR Conformational Study of a Variety of α-Anomers of C5-Substituted 2′-Deoxyuridines: Comparison to Their Antiherpetic β Counterparts" @default.
• W2033969179 cites W1591929564 @default.
• W2033969179 cites W1962972136 @default.
• W2033969179 cites W1965311327 @default.
• W2033969179 cites W1966477744 @default.
• W2033969179 cites W1973851519 @default.
• W2033969179 cites W1979478654 @default.
• W2033969179 cites W1989517603 @default.
• W2033969179 cites W1995344800 @default.
• W2033969179 cites W1997360594 @default.
• W2033969179 cites W2004990129 @default.
• W2033969179 cites W2011246523 @default.
• W2033969179 cites W2018573281 @default.
• W2033969179 cites W2025352183 @default.
• W2033969179 cites W2027718673 @default.
• W2033969179 cites W2030268030 @default.
• W2033969179 cites W2036410245 @default.
• W2033969179 cites W2037996594 @default.
• W2033969179 cites W2040653354 @default.
• W2033969179 cites W2049863403 @default.
• W2033969179 cites W2055240119 @default.
• W2033969179 cites W2056414768 @default.
• W2033969179 cites W2061822610 @default.
• W2033969179 cites W2066309541 @default.
• W2033969179 cites W2073134966 @default.
• W2033969179 cites W2075483585 @default.
• W2033969179 cites W2079630507 @default.
• W2033969179 cites W2125639615 @default.
• W2033969179 cites W2164057100 @default.
• W2033969179 cites W2165786297 @default.
• W2033969179 cites W23781914 @default.
• W2033969179 cites W265068126 @default.
• W2033969179 cites W2993638028 @default.
• W2033969179 cites W53123824 @default.
• W2033969179 doi "https://doi.org/10.1006/bbrc.2001.4921" @default.
• W2033969179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11355892" @default.
• W2033969179 hasPublicationYear "2001" @default.
• W2033969179 type Work @default.
• W2033969179 sameAs 2033969179 @default.
• W2033969179 citedByCount "7" @default.
• W2033969179 countsByYear W20339691792014 @default.
• W2033969179 countsByYear W20339691792021 @default.
• W2033969179 crossrefType "journal-article" @default.
• W2033969179 hasAuthorship W2033969179A5001493896 @default.
• W2033969179 hasAuthorship W2033969179A5010360036 @default.
• W2033969179 hasAuthorship W2033969179A5029050926 @default.
• W2033969179 hasAuthorship W2033969179A5062372955 @default.
• W2033969179 hasAuthorship W2033969179A5079985617 @default.
• W2033969179 hasConcept C111429119 @default.
• W2033969179 hasConcept C147789679 @default.
• W2033969179 hasConcept C150487720 @default.
• W2033969179 hasConcept C155518411 @default.
• W2033969179 hasConcept C173985810 @default.
• W2033969179 hasConcept C178790620 @default.
• W2033969179 hasConcept C181199279 @default.
• W2033969179 hasConcept C185592680 @default.
• W2033969179 hasConcept C18705241 @default.
• W2033969179 hasConcept C24107716 @default.
• W2033969179 hasConcept C2776568683 @default.
• W2033969179 hasConcept C2777709666 @default.
• W2033969179 hasConcept C2779413573 @default.
• W2033969179 hasConcept C2779461342 @default.
• W2033969179 hasConcept C2780378348 @default.
• W2033969179 hasConcept C32909587 @default.
• W2033969179 hasConcept C34490408 @default.
• W2033969179 hasConcept C55493867 @default.
• W2033969179 hasConcept C71240020 @default.
• W2033969179 hasConcept C7947691 @default.
• W2033969179 hasConceptScore W2033969179C111429119 @default.
• W2033969179 hasConceptScore W2033969179C147789679 @default.
• W2033969179 hasConceptScore W2033969179C150487720 @default.
• W2033969179 hasConceptScore W2033969179C155518411 @default.
• W2033969179 hasConceptScore W2033969179C173985810 @default.
• W2033969179 hasConceptScore W2033969179C178790620 @default.
• W2033969179 hasConceptScore W2033969179C181199279 @default.
• W2033969179 hasConceptScore W2033969179C185592680 @default.
• W2033969179 hasConceptScore W2033969179C18705241 @default.
• W2033969179 hasConceptScore W2033969179C24107716 @default.
• W2033969179 hasConceptScore W2033969179C2776568683 @default.
• W2033969179 hasConceptScore W2033969179C2777709666 @default.
• W2033969179 hasConceptScore W2033969179C2779413573 @default.
• W2033969179 hasConceptScore W2033969179C2779461342 @default.
• W2033969179 hasConceptScore W2033969179C2780378348 @default.
• W2033969179 hasConceptScore W2033969179C32909587 @default.
• W2033969179 hasConceptScore W2033969179C34490408 @default.
• W2033969179 hasConceptScore W2033969179C55493867 @default.
• W2033969179 hasConceptScore W2033969179C71240020 @default.
• W2033969179 hasConceptScore W2033969179C7947691 @default.
• W2033969179 hasIssue "5" @default.

• next