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- W2033969820 abstract "To assess the effects of environmental temperature on the response to hypoxia in neonates, we studied 5 unsedated lambs in the first week after birth. We catheterized the carotid artery (CA) and pulmonary artery (PA) (via the jugular vein). After at least one day, we measured pH, blood gases, arterial and mixed venous O2 content, VO2, heart rate (HR), CA and PA pressures, and cardiac output (CO) in both warm (W) (25°C) and cool (C) (17.4 ± 1.1°C) environments. In C, with no shivering, VO2 increased 40% (14.9 to 20.8 ml/kg/min) and arteriovenous O2 content difference (A-V) 19%, CO 18%, and HR 14%. In 4 lambs, we studied the same variables during hypoxia (FIO2=0.09 for 1 hr) at both temperatures. In C, hypoxia produced a greater fall of VO2 (26% vs. 6%) and of A-V (30% vs. 19%) and a smaller increase of CO (8% vs. 14%) and of HR (26% vs. 43%); in C, core temperature decreased more (2.1° vs. 0.4°), but base deficit was the same (-6 vs. -4.5 meq). Despite the greater fall in VO2 during hypoxia in C, the lowest value achieved was still higher than that in W, even during normoxia. Similarly, CO during hypoxia was greater in C than in W. These findings may explain variabilities reported in normal resting values and responses to hypoxia. They also indicate that, contrary to previous reports, during severe hypoxia neonates have a decreased reserve of metabolic and cardiovascular responses in a cool compared with a warm environment. (Supported by NIH grant HL 23681.)" @default.
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- W2033969820 date "1981-04-01" @default.
- W2033969820 modified "2023-09-25" @default.
- W2033969820 title "1426 EFFECTS OF AMBIENT TEMPERATURE ON CIRCULATION AND O2 CONSUMPTION (VO2) IN NEWBORN LAMBS, AT REST AND DURING ACUTE HYPOXIA" @default.
- W2033969820 doi "https://doi.org/10.1203/00006450-198104001-01455" @default.
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