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• W2033972585 abstract "Previous work has proposed rhoptry protein 2 (ROP2) as the physical link that tethers host mitochondria to the parasitophorous vacuole membrane (PVM) surrounding the intracellular parasite, Toxoplasma gondii. A recent analysis of the ROP2 structure, however, raised questions about this model. To determine whether ROP2 is necessary, we created a parasite line that lacks the entire ROP2 locus consisting of the three closely related genes, ROP2a, ROP2b and ROP8. We show that this knockout mutant retains the ability to recruit host mitochondria in a manner that is indistinguishable from the parental strain, re-opening the question of which molecules mediate this association." @default.
• W2033972585 created "2016-06-24" @default.
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• W2033972585 date "2010-10-01" @default.
• W2033972585 modified "2023-09-26" @default.
• W2033972585 title "Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8" @default.
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• W2033972585 doi "https://doi.org/10.1016/j.ijpara.2010.07.002" @default.
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