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• W2033974562 abstract "Hamster embryo cells were sequentially exposed to benzo[a]pyrene (BaP) (3 days) and different phorbol esters (4 days). Compounds which have been shown to act as tumor promoters in mouse skin carcinogenesis, showed a promotion-like effect on the formation of morphologically transformed colonies, while non-promoting analogs did not enhance the transformation frequency. In experiments where the exposure sequence was reversed, i.e. 12-O-tetradecanoyl phorbol-13-acetate (TPA) in the first exposure period and BaP in the second period, no significant enhancement of the transformation frequency was observed. The exposure to a low concentration of BaP in the second exposure period following a higher concentration in the first period, resulted in a strong enhancement of the transformation frequency suggesting that BaP also acts as a promoter." @default.
• W2033974562 created "2016-06-24" @default.
• W2033974562 creator A5056841206 @default.
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• W2033974562 date "1982-10-01" @default.
• W2033974562 modified "2023-09-25" @default.
• W2033974562 title "Promotional effect of different phorbol esters on morphological transformation of hamster embryo cells" @default.
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• W2033974562 doi "https://doi.org/10.1016/0304-3835(82)90101-x" @default.
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