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- W2033975722 abstract "We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic–clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate." @default.
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- W2033975722 date "2001-07-01" @default.
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- W2033975722 title "Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates" @default.
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- W2033975722 doi "https://doi.org/10.1016/s0014-827x(01)01062-x" @default.
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