Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033983791> ?p ?o ?g. }
- W2033983791 endingPage "1566" @default.
- W2033983791 startingPage "1552" @default.
- W2033983791 abstract "Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal and differentiation of cancer-initiating cells. One such recurrent mutation targets the binding pocket of the ubiquitin ligase Fbxw7. Missense FBXW7 mutations are prevalent in various tumors, including T cell acute lymphoblastic leukemia (T-ALL). To study the effects of such lesions, we generated animals carrying regulatable Fbxw7 mutant alleles. Here, we show that these mutations specifically bolster cancer-initiating cell activity in collaboration with Notch1 oncogenes but spare normal hematopoietic stem cell function. We were also able to show that FBXW7 mutations specifically affect the ubiquitylation and half-life of c-Myc protein, a key T-ALL oncogene. Using animals carrying c-Myc fusion alleles, we connected Fbxw7 function to c-Myc abundance and correlated c-Myc expression to leukemia-initiating activity. Finally, we demonstrated that small-molecule-mediated suppression of MYC activity leads to T-ALL remission, suggesting an effective therapeutic strategy." @default.
- W2033983791 created "2016-06-24" @default.
- W2033983791 creator A5006848089 @default.
- W2033983791 creator A5014490969 @default.
- W2033983791 creator A5015010943 @default.
- W2033983791 creator A5020549289 @default.
- W2033983791 creator A5024753086 @default.
- W2033983791 creator A5025489542 @default.
- W2033983791 creator A5029030202 @default.
- W2033983791 creator A5029718580 @default.
- W2033983791 creator A5037890359 @default.
- W2033983791 creator A5043149847 @default.
- W2033983791 creator A5045424501 @default.
- W2033983791 creator A5046937022 @default.
- W2033983791 creator A5065131405 @default.
- W2033983791 creator A5084923564 @default.
- W2033983791 date "2013-06-01" @default.
- W2033983791 modified "2023-10-10" @default.
- W2033983791 title "The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability" @default.
- W2033983791 cites W1954102273 @default.
- W2033983791 cites W1964891290 @default.
- W2033983791 cites W1965428318 @default.
- W2033983791 cites W1966218963 @default.
- W2033983791 cites W1973751980 @default.
- W2033983791 cites W1982023788 @default.
- W2033983791 cites W1989804575 @default.
- W2033983791 cites W1990320777 @default.
- W2033983791 cites W2000589976 @default.
- W2033983791 cites W2004603629 @default.
- W2033983791 cites W2009949436 @default.
- W2033983791 cites W2012538791 @default.
- W2033983791 cites W2015377623 @default.
- W2033983791 cites W2020419538 @default.
- W2033983791 cites W2028238878 @default.
- W2033983791 cites W2038676786 @default.
- W2033983791 cites W2038970416 @default.
- W2033983791 cites W2041175983 @default.
- W2033983791 cites W2041535798 @default.
- W2033983791 cites W2045766577 @default.
- W2033983791 cites W2046719062 @default.
- W2033983791 cites W2047746661 @default.
- W2033983791 cites W2054551614 @default.
- W2033983791 cites W2060605982 @default.
- W2033983791 cites W2060710804 @default.
- W2033983791 cites W2063124444 @default.
- W2033983791 cites W2064026123 @default.
- W2033983791 cites W2068646859 @default.
- W2033983791 cites W2069795464 @default.
- W2033983791 cites W2071152209 @default.
- W2033983791 cites W2071746976 @default.
- W2033983791 cites W2081536052 @default.
- W2033983791 cites W2086943873 @default.
- W2033983791 cites W2099698731 @default.
- W2033983791 cites W2106836163 @default.
- W2033983791 cites W2111167992 @default.
- W2033983791 cites W2112357436 @default.
- W2033983791 cites W2112738731 @default.
- W2033983791 cites W2116274406 @default.
- W2033983791 cites W2116965161 @default.
- W2033983791 cites W2120572492 @default.
- W2033983791 cites W2121266842 @default.
- W2033983791 cites W2124201592 @default.
- W2033983791 cites W2129129812 @default.
- W2033983791 cites W2132230421 @default.
- W2033983791 cites W2134471382 @default.
- W2033983791 cites W2135763107 @default.
- W2033983791 cites W2137116933 @default.
- W2033983791 cites W2144762247 @default.
- W2033983791 cites W2147253462 @default.
- W2033983791 cites W2147373929 @default.
- W2033983791 cites W2147587166 @default.
- W2033983791 cites W2157830903 @default.
- W2033983791 cites W2161577298 @default.
- W2033983791 cites W2163965017 @default.
- W2033983791 cites W2167869412 @default.
- W2033983791 doi "https://doi.org/10.1016/j.cell.2013.05.041" @default.
- W2033983791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146439" @default.
- W2033983791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23791182" @default.
- W2033983791 hasPublicationYear "2013" @default.
- W2033983791 type Work @default.
- W2033983791 sameAs 2033983791 @default.
- W2033983791 citedByCount "280" @default.
- W2033983791 countsByYear W20339837912013 @default.
- W2033983791 countsByYear W20339837912014 @default.
- W2033983791 countsByYear W20339837912015 @default.
- W2033983791 countsByYear W20339837912016 @default.
- W2033983791 countsByYear W20339837912017 @default.
- W2033983791 countsByYear W20339837912018 @default.
- W2033983791 countsByYear W20339837912019 @default.
- W2033983791 countsByYear W20339837912020 @default.
- W2033983791 countsByYear W20339837912021 @default.
- W2033983791 countsByYear W20339837912022 @default.
- W2033983791 countsByYear W20339837912023 @default.
- W2033983791 crossrefType "journal-article" @default.
- W2033983791 hasAuthorship W2033983791A5006848089 @default.
- W2033983791 hasAuthorship W2033983791A5014490969 @default.
- W2033983791 hasAuthorship W2033983791A5015010943 @default.
- W2033983791 hasAuthorship W2033983791A5020549289 @default.