Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033991618> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2033991618 endingPage "17" @default.
- W2033991618 startingPage "15" @default.
- W2033991618 abstract "Forty-six patients with stable angina pectoris were randomized to receive either oral sustained-release nitroglycerin (SRNG, 6.5 mg) or placebo (P) 3 times a day for a 2-week double-blind trial. They were investigated for the frequency of anginal episodes, for sublingual nitroglycerin consumption and for exercise tolerance. There was a slight but significant decrease in the number of anginal episodes (6.4 ±1.5 episodes/week with P, 4.9 ± 1.7 with SRNG, p < 0.005) and sublingual nitroglycerin consumption (3.9 ± 1 tablets/week with P, 2.7 ± 1 with SRNG, p < 0.005). The patients performed 3 upright multistage (increments of 30 W every 3 minutes) exercise tests on a bicycle ergometer before the start of the study and 1 hour after the intake of SRNG or P, at the end of each double-blind phase. Exercise capacity, expressed as exercise duration, increased from 8.9 ± 3.8 minutes with P to 10.2 ± 3.8 minutes with SRNG (14.6 %; p < 0.001). At symptom-limited exercise, ST depression was significantly reduced (p < 0.05) during the SRNG phase. Thirty-four patients (74 %) reached a higher peak heart rate (139 beats/min with P, 145 beats/min with SRNG; p < 0.001) and 35 patients (76 %) a higher ratepressure product (+ 6 %; p < 0.001). These changes in exercise tolerance are relatively modest and at least 11 patients would have benefited from larger doses of nitrates. Although the individual variability of dose response to nitrates is wide, it is concluded that oral SRNG (6.5 mg 3 times daily) is an effective prophylactic therapy in stable angina pectoris and that exercise capacity, measured 1 hour after administration, is improved." @default.
- W2033991618 created "2016-06-24" @default.
- W2033991618 creator A5003034879 @default.
- W2033991618 creator A5006425352 @default.
- W2033991618 creator A5058830405 @default.
- W2033991618 date "1984-01-01" @default.
- W2033991618 modified "2023-09-27" @default.
- W2033991618 title "Oral sustained-release nitroglycerin in chronic stable angina: A multicenter, double-blind, randomized crossover trial" @default.
- W2033991618 cites W1964384852 @default.
- W2033991618 cites W1965959205 @default.
- W2033991618 cites W1970038371 @default.
- W2033991618 cites W1975092445 @default.
- W2033991618 cites W1989735248 @default.
- W2033991618 cites W2023197655 @default.
- W2033991618 cites W2028374720 @default.
- W2033991618 cites W2040497473 @default.
- W2033991618 cites W2042616569 @default.
- W2033991618 cites W2143327141 @default.
- W2033991618 cites W2171347902 @default.
- W2033991618 doi "https://doi.org/10.1016/0002-9149(84)90676-3" @default.
- W2033991618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6419574" @default.
- W2033991618 hasPublicationYear "1984" @default.
- W2033991618 type Work @default.
- W2033991618 sameAs 2033991618 @default.
- W2033991618 citedByCount "14" @default.
- W2033991618 crossrefType "journal-article" @default.
- W2033991618 hasAuthorship W2033991618A5003034879 @default.
- W2033991618 hasAuthorship W2033991618A5006425352 @default.
- W2033991618 hasAuthorship W2033991618A5058830405 @default.
- W2033991618 hasConcept C126322002 @default.
- W2033991618 hasConcept C142724271 @default.
- W2033991618 hasConcept C164705383 @default.
- W2033991618 hasConcept C168563851 @default.
- W2033991618 hasConcept C204787440 @default.
- W2033991618 hasConcept C27081682 @default.
- W2033991618 hasConcept C2777953023 @default.
- W2033991618 hasConcept C2778425758 @default.
- W2033991618 hasConcept C2779350572 @default.
- W2033991618 hasConcept C2991744798 @default.
- W2033991618 hasConcept C42219234 @default.
- W2033991618 hasConcept C500558357 @default.
- W2033991618 hasConcept C71924100 @default.
- W2033991618 hasConcept C84393581 @default.
- W2033991618 hasConcept C87813604 @default.
- W2033991618 hasConceptScore W2033991618C126322002 @default.
- W2033991618 hasConceptScore W2033991618C142724271 @default.
- W2033991618 hasConceptScore W2033991618C164705383 @default.
- W2033991618 hasConceptScore W2033991618C168563851 @default.
- W2033991618 hasConceptScore W2033991618C204787440 @default.
- W2033991618 hasConceptScore W2033991618C27081682 @default.
- W2033991618 hasConceptScore W2033991618C2777953023 @default.
- W2033991618 hasConceptScore W2033991618C2778425758 @default.
- W2033991618 hasConceptScore W2033991618C2779350572 @default.
- W2033991618 hasConceptScore W2033991618C2991744798 @default.
- W2033991618 hasConceptScore W2033991618C42219234 @default.
- W2033991618 hasConceptScore W2033991618C500558357 @default.
- W2033991618 hasConceptScore W2033991618C71924100 @default.
- W2033991618 hasConceptScore W2033991618C84393581 @default.
- W2033991618 hasConceptScore W2033991618C87813604 @default.
- W2033991618 hasIssue "1" @default.
- W2033991618 hasLocation W20339916181 @default.
- W2033991618 hasLocation W20339916182 @default.
- W2033991618 hasOpenAccess W2033991618 @default.
- W2033991618 hasPrimaryLocation W20339916181 @default.
- W2033991618 hasRelatedWork W1533026973 @default.
- W2033991618 hasRelatedWork W1984223073 @default.
- W2033991618 hasRelatedWork W2011844417 @default.
- W2033991618 hasRelatedWork W2077168757 @default.
- W2033991618 hasRelatedWork W2090075170 @default.
- W2033991618 hasRelatedWork W2186811653 @default.
- W2033991618 hasRelatedWork W2424937630 @default.
- W2033991618 hasRelatedWork W2436802121 @default.
- W2033991618 hasRelatedWork W2467740035 @default.
- W2033991618 hasRelatedWork W2184512671 @default.
- W2033991618 hasVolume "53" @default.
- W2033991618 isParatext "false" @default.
- W2033991618 isRetracted "false" @default.
- W2033991618 magId "2033991618" @default.
- W2033991618 workType "article" @default.