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• W2033993574 startingPage "187" @default.
• W2033993574 abstract "Normal C57Bl/6 mouse spleen cells cultured alone for 4 days (suppressor generation culture) were shown, in mixing experiments, to suppress the primary cytotoxic T-lymphocyte (CTL) response of freshly explanted C57Bl/6 spleen cells against allogeneic tumor cells. This suppression was not apparent when spleen cells from mice pretreated with 1 mg/kg vinblastine (VLB), were used for the suppressor generation culture. However, suppression was noted with vincristine (VCR) at the same dose. Similarly, CTL generation cultures of spleen cells from mice treated with 12 LD10 VLB (3 mg/kg) were inhibited while those of spleen cells from mice treated with 12 LD10 VCR (1.5 mg/kg) were not. These effects observed following in vivo injection of the vinca alkaloids were also seen following addition of the drugs in vitro. In these experiments various anticancer drugs [arabinofuranosylcytosine (Ara-C), 200–1000 nM; Adriamycin (AM), 10–100 nM; VCR, 1–100 nM; VLB, 1–100 nM] were added to suppressor cell generation cultures. Ara-C (1 μM) and VLB (10 nM) inhibited the development of suppressor activity, whereas AM (100 nM) and VCR (100 nM) had no effect. The data indicate that these effects were not due to differences in the number of viable cells recovered. On the other hand, when these drugs were added to CTL generation culture at a responder to stimulator cell ratio of 50:1 (a ratio which gave somewhat less than optimal responses), Ara-C markedly inhibited the development of CTL, VCR and VLB both caused a dose dependent inhibition of the response and AM had no effect. In other experiments, the development of a primary humoral response to SRBC in culture with spleen cells from drug-treated donor mice was more sensitive to VCR than to VLB. These data show that VCR and VLB have different selective effects on components and/or functions of immune responses." @default.
• W2033993574 created "2016-06-24" @default.
• W2033993574 creator A5007091924 @default.
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• W2033993574 date "1982-01-01" @default.
• W2033993574 modified "2023-09-27" @default.
• W2033993574 title "The differential sensitivity of T cell immune functions to vincristine and vinblastine" @default.
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• W2033993574 doi "https://doi.org/10.1016/0192-0561(82)90048-0" @default.
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• W2033993574 hasPublicationYear "1982" @default.
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