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• W2034000134 abstract "Recent studies have shown that indoleamine 2,3-dioxygenase (IDO) plays a pivotal role in the modulation of immune response against tumor and virus infection. Here we demonstrate the pro-apoptotic effect of l-kynurenine, a tryptophan catabolite of IDO, on human NK cell line, NK92 MI. Treatment with l-kynurenine dose-dependently induced growth inhibition and apoptosis in NK92 MI cells. Treatment with the antioxidant NAC completely protected cells from l-kynurenine-induced apoptosis. Moreover, we found that treatment with Z-VAD-fmk and ZB4 slightly inhibited l-kynurenine-induced apoptosis, suggesting that l-kynurenine-induced apoptosis in NK cells occurs primarily through an ROS mediated pathway. We observed that the presence of NAC blocks cytochrome c release and activation of caspase-3 during l-kynurenine-induced apoptosis. Overall, we conclude that l-kynurenine resulting from IDO can cause cell death via ROS pathway in NK cells. Our findings provide a new insight into the interaction between NK cells and IDO positive cancer cells in regulating immune responses." @default.
• W2034000134 created "2016-06-24" @default.
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• W2034000134 date "2011-08-01" @default.
• W2034000134 modified "2023-09-26" @default.
• W2034000134 title "l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species" @default.
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• W2034000134 doi "https://doi.org/10.1016/j.intimp.2011.02.005" @default.
• W2034000134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21352963" @default.
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