FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034000908> ?p ?o ?g. }

• W2034000908 endingPage "1292" @default.
• W2034000908 startingPage "1279" @default.
• W2034000908 abstract "Transplant of immature cardiomyocytes is recently attracting a great deal of interest as a new experimental strategy for the treatment of failing hearts. Full understanding of normal cardiomyogenesis is essential to make this regenerative therapy feasible. We analyzed the molecular and functional changes of Ca(2+) handling proteins during development of the mouse heart from early embryo at 9.5 days postcoitum (dpc) through adulthood. From the early to the late (18 dpc) embryonic stage, mRNAs estimated by the real time PCR for ryanodine receptor (type 2, RyR2), sarcoplasmic reticulum (SR) Ca(2+) pump (type 2, SERCA2) and phospholamban (PLB) increased by 3-15 fold in the values normalized to GAPDH mRNA, although Na(+)/Ca(2+) exchanger (type 1, NCX1) mRNA was unchanged. After birth, there was a further increase in the mRNAs for RyR2, SERCA2 and PLB by 18-33 fold, but a 50% decrease in NCX1 mRNA. The protein levels of RyR2, SERCA2, PLB and NCX1, which were normalized to total protein, showed qualitatively parallel developmental changes. L-type Ca(2+) channel currents (I(Ca-L)) were increased during the development (1.3-fold at 18 dpc, 2.2-fold at adult stage, vs. 9.5 dpc). At 9.5 dpc, the Ca(2+) transient was, unlike adulthood, unaffected by the SR blockers, ryanodine (5 microM) and thapsigargin (2 microM), and also by a blocker of the Ca(2+) entry via Na(+)/Ca(2+) exchanger, KB-R 7943 (1 microM). The Ca(2+) transient was abolished after application of nisoldipine (5 microM). These results indicate that activator Ca(2+) for contraction in the early embryonic stage depends almost entirely on I(Ca-L)." @default.
• W2034000908 created "2016-06-24" @default.
• W2034000908 creator A5002110232 @default.
• W2034000908 creator A5003406700 @default.
• W2034000908 creator A5039379192 @default.
• W2034000908 creator A5059094129 @default.
• W2034000908 creator A5069292529 @default.
• W2034000908 creator A5079500797 @default.
• W2034000908 creator A5080572816 @default.
• W2034000908 creator A5083257131 @default.
• W2034000908 date "2002-08-01" @default.
• W2034000908 modified "2023-10-15" @default.
• W2034000908 title "Developmental changes of Ca2+ handling in mouse ventricular cells from early embryo to adulthood" @default.
• W2034000908 cites W1631250427 @default.
• W2034000908 cites W1967889754 @default.
• W2034000908 cites W1971936727 @default.
• W2034000908 cites W1972662556 @default.
• W2034000908 cites W1980813028 @default.
• W2034000908 cites W1994189373 @default.
• W2034000908 cites W1997312408 @default.
• W2034000908 cites W2009781552 @default.
• W2034000908 cites W2028649508 @default.
• W2034000908 cites W2029339610 @default.
• W2034000908 cites W2029920925 @default.
• W2034000908 cites W2046786443 @default.
• W2034000908 cites W2050260272 @default.
• W2034000908 cites W2063288946 @default.
• W2034000908 cites W2077580209 @default.
• W2034000908 cites W2080293185 @default.
• W2034000908 cites W2082235062 @default.
• W2034000908 cites W2085267754 @default.
• W2034000908 cites W2107267961 @default.
• W2034000908 cites W2111867044 @default.
• W2034000908 cites W2118810404 @default.
• W2034000908 cites W2126440444 @default.
• W2034000908 cites W2131388270 @default.
• W2034000908 cites W2139909492 @default.
• W2034000908 cites W2141260882 @default.
• W2034000908 cites W2142226883 @default.
• W2034000908 cites W2144219092 @default.
• W2034000908 cites W2157013107 @default.
• W2034000908 cites W2158644069 @default.
• W2034000908 cites W2165992501 @default.
• W2034000908 cites W2275889027 @default.
• W2034000908 doi "https://doi.org/10.1016/s0024-3205(02)01826-x" @default.
• W2034000908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12106593" @default.
• W2034000908 hasPublicationYear "2002" @default.
• W2034000908 type Work @default.
• W2034000908 sameAs 2034000908 @default.
• W2034000908 citedByCount "80" @default.
• W2034000908 countsByYear W20340009082012 @default.
• W2034000908 countsByYear W20340009082013 @default.
• W2034000908 countsByYear W20340009082014 @default.
• W2034000908 countsByYear W20340009082015 @default.
• W2034000908 countsByYear W20340009082016 @default.
• W2034000908 countsByYear W20340009082017 @default.
• W2034000908 countsByYear W20340009082018 @default.
• W2034000908 countsByYear W20340009082019 @default.
• W2034000908 countsByYear W20340009082020 @default.
• W2034000908 countsByYear W20340009082021 @default.
• W2034000908 countsByYear W20340009082022 @default.
• W2034000908 countsByYear W20340009082023 @default.
• W2034000908 crossrefType "journal-article" @default.
• W2034000908 hasAuthorship W2034000908A5002110232 @default.
• W2034000908 hasAuthorship W2034000908A5003406700 @default.
• W2034000908 hasAuthorship W2034000908A5039379192 @default.
• W2034000908 hasAuthorship W2034000908A5059094129 @default.
• W2034000908 hasAuthorship W2034000908A5069292529 @default.
• W2034000908 hasAuthorship W2034000908A5079500797 @default.
• W2034000908 hasAuthorship W2034000908A5080572816 @default.
• W2034000908 hasAuthorship W2034000908A5083257131 @default.
• W2034000908 hasConcept C104317684 @default.
• W2034000908 hasConcept C105580179 @default.
• W2034000908 hasConcept C113217602 @default.
• W2034000908 hasConcept C126322002 @default.
• W2034000908 hasConcept C134018914 @default.
• W2034000908 hasConcept C158617107 @default.
• W2034000908 hasConcept C16685009 @default.
• W2034000908 hasConcept C17137333 @default.
• W2034000908 hasConcept C185592680 @default.
• W2034000908 hasConcept C190712762 @default.
• W2034000908 hasConcept C2775953344 @default.
• W2034000908 hasConcept C2777146706 @default.
• W2034000908 hasConcept C2777735026 @default.
• W2034000908 hasConcept C519063684 @default.
• W2034000908 hasConcept C55493867 @default.
• W2034000908 hasConcept C71924100 @default.
• W2034000908 hasConcept C86803240 @default.
• W2034000908 hasConcept C95444343 @default.
• W2034000908 hasConceptScore W2034000908C104317684 @default.
• W2034000908 hasConceptScore W2034000908C105580179 @default.
• W2034000908 hasConceptScore W2034000908C113217602 @default.
• W2034000908 hasConceptScore W2034000908C126322002 @default.
• W2034000908 hasConceptScore W2034000908C134018914 @default.
• W2034000908 hasConceptScore W2034000908C158617107 @default.
• W2034000908 hasConceptScore W2034000908C16685009 @default.
• W2034000908 hasConceptScore W2034000908C17137333 @default.
• W2034000908 hasConceptScore W2034000908C185592680 @default.

• next