FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034001008> ?p ?o ?g. }

• W2034001008 endingPage "70" @default.
• W2034001008 startingPage "65" @default.
• W2034001008 abstract "Objectives We have previously shown that serum prostate-specific antigen (PSA) is proportional to prostate cancer volume and that progression of prostate cancer is proportional to volume, but other investigators have not found serum PSA to be as useful in predicting pathologic stage at the time of radical prostatectomy. Because our series is the only study to examine prospectively all radical specimens at 3-mm intervals, we have examined the relationship between serum PSA and the morphologic indicators of cancer progression in our first 350 radical prostatectomies. Methods Preoperative serum PSA level was tabulated in 350 consecutive patients with prostate adenocarcinoma and compared with morphologic variables in the radical prostatectomy specimen. Morphologic variables included cancer volume, histologic grade, capsular penetration, seminal vesicle invasion, and lymph node metastasis. Results Serum PSA showed strong correlation with all morphologic variables, which were highly intercorrelated. Serum PSA level was strongly correlated with cancer volume, histologic grade, and frequency of regional spread to lymph nodes. Close intercorrelations found between all variables were translated into a scale relating each level of serum PSA elevation to stage of disease in morphologic terms. Using this scale, serum PSA level can contribute to patient evaluation and treatment decisions in men with prostate cancer. Conclusions. Serum PSA is primarily determined by prostate cancer volume and secondarily by the percentage of high-grade cancer (Gleason grades 4 and 5) in the prostate. Because of this basic relationship, serum levels of PSA provide a clinically useful estimate of morphologic findings in the prostate. Serial PSA determinations should reflect the growth of the cancer as well as the gradual evolution of more malignant cells with the passage of time. The use of a serum PSA-based rating scale can contribute to patient evaluation and treatment decisions in men with prostate cancer." @default.
• W2034001008 created "2016-06-24" @default.
• W2034001008 creator A5007787587 @default.
• W2034001008 creator A5035337773 @default.
• W2034001008 creator A5068820671 @default.
• W2034001008 creator A5071647275 @default.
• W2034001008 date "1995-07-01" @default.
• W2034001008 modified "2023-09-26" @default.
• W2034001008 title "Serum prostate-specific antigen and the biologic progression of prostate cancer" @default.
• W2034001008 cites W1571849492 @default.
• W2034001008 cites W1980245127 @default.
• W2034001008 cites W1997134471 @default.
• W2034001008 cites W2054921086 @default.
• W2034001008 cites W2058525489 @default.
• W2034001008 cites W2061879006 @default.
• W2034001008 cites W2064028125 @default.
• W2034001008 cites W2076409735 @default.
• W2034001008 cites W2330292521 @default.
• W2034001008 cites W2397717046 @default.
• W2034001008 cites W2400762825 @default.
• W2034001008 cites W2406502491 @default.
• W2034001008 cites W2409274539 @default.
• W2034001008 cites W2417221359 @default.
• W2034001008 cites W2418785680 @default.
• W2034001008 cites W38417416 @default.
• W2034001008 doi "https://doi.org/10.1016/s0090-4295(99)80161-7" @default.
• W2034001008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7541589" @default.
• W2034001008 hasPublicationYear "1995" @default.
• W2034001008 type Work @default.
• W2034001008 sameAs 2034001008 @default.
• W2034001008 citedByCount "50" @default.
• W2034001008 countsByYear W20340010082015 @default.
• W2034001008 countsByYear W20340010082016 @default.
• W2034001008 countsByYear W20340010082017 @default.
• W2034001008 countsByYear W20340010082022 @default.
• W2034001008 crossrefType "journal-article" @default.
• W2034001008 hasAuthorship W2034001008A5007787587 @default.
• W2034001008 hasAuthorship W2034001008A5035337773 @default.
• W2034001008 hasAuthorship W2034001008A5068820671 @default.
• W2034001008 hasAuthorship W2034001008A5071647275 @default.
• W2034001008 hasBestOaLocation W20340010081 @default.
• W2034001008 hasConcept C121608353 @default.
• W2034001008 hasConcept C126322002 @default.
• W2034001008 hasConcept C126894567 @default.
• W2034001008 hasConcept C142724271 @default.
• W2034001008 hasConcept C143998085 @default.
• W2034001008 hasConcept C146357865 @default.
• W2034001008 hasConcept C151730666 @default.
• W2034001008 hasConcept C2776235491 @default.
• W2034001008 hasConcept C2779013556 @default.
• W2034001008 hasConcept C2779466945 @default.
• W2034001008 hasConcept C2780192828 @default.
• W2034001008 hasConcept C2781406297 @default.
• W2034001008 hasConcept C71924100 @default.
• W2034001008 hasConcept C86803240 @default.
• W2034001008 hasConceptScore W2034001008C121608353 @default.
• W2034001008 hasConceptScore W2034001008C126322002 @default.
• W2034001008 hasConceptScore W2034001008C126894567 @default.
• W2034001008 hasConceptScore W2034001008C142724271 @default.
• W2034001008 hasConceptScore W2034001008C143998085 @default.
• W2034001008 hasConceptScore W2034001008C146357865 @default.
• W2034001008 hasConceptScore W2034001008C151730666 @default.
• W2034001008 hasConceptScore W2034001008C2776235491 @default.
• W2034001008 hasConceptScore W2034001008C2779013556 @default.
• W2034001008 hasConceptScore W2034001008C2779466945 @default.
• W2034001008 hasConceptScore W2034001008C2780192828 @default.
• W2034001008 hasConceptScore W2034001008C2781406297 @default.
• W2034001008 hasConceptScore W2034001008C71924100 @default.
• W2034001008 hasConceptScore W2034001008C86803240 @default.
• W2034001008 hasIssue "1" @default.
• W2034001008 hasLocation W20340010081 @default.
• W2034001008 hasLocation W20340010082 @default.
• W2034001008 hasOpenAccess W2034001008 @default.
• W2034001008 hasPrimaryLocation W20340010081 @default.
• W2034001008 hasRelatedWork W189616576 @default.
• W2034001008 hasRelatedWork W1979955543 @default.
• W2034001008 hasRelatedWork W2002000959 @default.
• W2034001008 hasRelatedWork W2060445317 @default.
• W2034001008 hasRelatedWork W2092129431 @default.
• W2034001008 hasRelatedWork W2169120358 @default.
• W2034001008 hasRelatedWork W2395453437 @default.
• W2034001008 hasRelatedWork W2979919955 @default.
• W2034001008 hasRelatedWork W3087899116 @default.
• W2034001008 hasRelatedWork W93186087 @default.
• W2034001008 hasVolume "46" @default.
• W2034001008 isParatext "false" @default.
• W2034001008 isRetracted "false" @default.
• W2034001008 magId "2034001008" @default.
• W2034001008 workType "article" @default.