FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034001161> ?p ?o ?g. }

• W2034001161 endingPage "463" @default.
• W2034001161 startingPage "457" @default.
• W2034001161 abstract "Treatment with statins is considered a first line therapy in atherosclerotic disease. Intraplaque angiogenesis is involved in plaque progression and instability. It remains unclear whether the beneficial effect of statin treatment in humans is achieved through reduced intraplaque angiogenesis. The aim of this study was to evaluate the capillaries density in carotid plaques removed from patients treated with statin versus untreated patients.We studied 102 patients who underwent carotid endarterectomy: 98 of them met the inclusion criteria and entered the study; 75 men and 23 women; mean age 66+/-8 years (range 42-83 years). Forty-three patients (44%) were on statin treatment at least 3 months before endarterectomy and 55 (56%) had never received statin treatment. The intensity of intraplaque angiogenesis was evaluated with immunohistochemistry using the antibody CD34. The number of capillaries per mm(2) was measured with a custom designed image tool analysis. With the exception of serum total cholesterol levels and serum low-density cholesterol levels, the two groups of patients did not vary significantly in cardiovascular risk factors and in parameters pertaining to the procedure profile. Patients on statin treatment had less capillaries per mm(2) than patients not receiving this kind of drugs (0.97+/-0.61 per mm(2) versus 1.39+/-0.98 per mm(2), p=0.031). Univariate associations between possible explanatory variables and number of capillaries per mm(2) were tested using Spearman rank R. Variables associated with a p-value <0.20 (age, serum creatinine, serum total cholesterol, serum low-density lipoprotein, serum homocysteine, presence of diabetes mellitus and statin treatment) were entered in a multivariable model. Multivariate analysis showed that statin treatment was the only independent predictor (t=-5.39, p<0.001) of intraplaque angiogenesis.Statin therapy is associated with reduced intraplaque angiogenesis in the carotid arteries. This could provide an explanation for the beneficial effects of this kind of drug on patients with atherosclerotic disease." @default.
• W2034001161 created "2016-06-24" @default.
• W2034001161 creator A5012748201 @default.
• W2034001161 creator A5018170454 @default.
• W2034001161 creator A5022488178 @default.
• W2034001161 creator A5026119862 @default.
• W2034001161 creator A5026873624 @default.
• W2034001161 creator A5028942611 @default.
• W2034001161 creator A5077271389 @default.
• W2034001161 creator A5078668808 @default.
• W2034001161 date "2007-06-01" @default.
• W2034001161 modified "2023-09-25" @default.
• W2034001161 title "Statin treated patients have reduced intraplaque angiogenesis in carotid endarterectomy specimens" @default.
• W2034001161 cites W1561059299 @default.
• W2034001161 cites W1783580437 @default.
• W2034001161 cites W1981192304 @default.
• W2034001161 cites W1985564012 @default.
• W2034001161 cites W1986858103 @default.
• W2034001161 cites W2020594884 @default.
• W2034001161 cites W2028103879 @default.
• W2034001161 cites W2057576736 @default.
• W2034001161 cites W2060709766 @default.
• W2034001161 cites W2068304309 @default.
• W2034001161 cites W2073751205 @default.
• W2034001161 cites W2074253462 @default.
• W2034001161 cites W2076110739 @default.
• W2034001161 cites W2081038112 @default.
• W2034001161 cites W2090278791 @default.
• W2034001161 cites W2091911167 @default.
• W2034001161 cites W2092692976 @default.
• W2034001161 cites W2093018150 @default.
• W2034001161 cites W2095426703 @default.
• W2034001161 cites W2106084279 @default.
• W2034001161 cites W2110941452 @default.
• W2034001161 cites W2113771464 @default.
• W2034001161 cites W2115268091 @default.
• W2034001161 cites W2119210523 @default.
• W2034001161 cites W2147912194 @default.
• W2034001161 cites W2152639592 @default.
• W2034001161 cites W2155598961 @default.
• W2034001161 cites W2163127813 @default.
• W2034001161 cites W2322095705 @default.
• W2034001161 cites W2322356560 @default.
• W2034001161 cites W2410386716 @default.
• W2034001161 doi "https://doi.org/10.1016/j.atherosclerosis.2007.01.035" @default.
• W2034001161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17335827" @default.
• W2034001161 hasPublicationYear "2007" @default.
• W2034001161 type Work @default.
• W2034001161 sameAs 2034001161 @default.
• W2034001161 citedByCount "58" @default.
• W2034001161 countsByYear W20340011612012 @default.
• W2034001161 countsByYear W20340011612013 @default.
• W2034001161 countsByYear W20340011612014 @default.
• W2034001161 countsByYear W20340011612015 @default.
• W2034001161 countsByYear W20340011612016 @default.
• W2034001161 countsByYear W20340011612017 @default.
• W2034001161 countsByYear W20340011612018 @default.
• W2034001161 countsByYear W20340011612019 @default.
• W2034001161 countsByYear W20340011612020 @default.
• W2034001161 countsByYear W20340011612021 @default.
• W2034001161 countsByYear W20340011612022 @default.
• W2034001161 countsByYear W20340011612023 @default.
• W2034001161 crossrefType "journal-article" @default.
• W2034001161 hasAuthorship W2034001161A5012748201 @default.
• W2034001161 hasAuthorship W2034001161A5018170454 @default.
• W2034001161 hasAuthorship W2034001161A5022488178 @default.
• W2034001161 hasAuthorship W2034001161A5026119862 @default.
• W2034001161 hasAuthorship W2034001161A5026873624 @default.
• W2034001161 hasAuthorship W2034001161A5028942611 @default.
• W2034001161 hasAuthorship W2034001161A5077271389 @default.
• W2034001161 hasAuthorship W2034001161A5078668808 @default.
• W2034001161 hasConcept C126322002 @default.
• W2034001161 hasConcept C126894567 @default.
• W2034001161 hasConcept C142724271 @default.
• W2034001161 hasConcept C144301174 @default.
• W2034001161 hasConcept C164705383 @default.
• W2034001161 hasConcept C2776839432 @default.
• W2034001161 hasConcept C2778271429 @default.
• W2034001161 hasConcept C2779745121 @default.
• W2034001161 hasConcept C2780394083 @default.
• W2034001161 hasConcept C2781068581 @default.
• W2034001161 hasConcept C2987047532 @default.
• W2034001161 hasConcept C38180746 @default.
• W2034001161 hasConcept C71924100 @default.
• W2034001161 hasConcept C90924648 @default.
• W2034001161 hasConceptScore W2034001161C126322002 @default.
• W2034001161 hasConceptScore W2034001161C126894567 @default.
• W2034001161 hasConceptScore W2034001161C142724271 @default.
• W2034001161 hasConceptScore W2034001161C144301174 @default.
• W2034001161 hasConceptScore W2034001161C164705383 @default.
• W2034001161 hasConceptScore W2034001161C2776839432 @default.
• W2034001161 hasConceptScore W2034001161C2778271429 @default.
• W2034001161 hasConceptScore W2034001161C2779745121 @default.
• W2034001161 hasConceptScore W2034001161C2780394083 @default.
• W2034001161 hasConceptScore W2034001161C2781068581 @default.
• W2034001161 hasConceptScore W2034001161C2987047532 @default.
• W2034001161 hasConceptScore W2034001161C38180746 @default.
• W2034001161 hasConceptScore W2034001161C71924100 @default.

• next