Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034001737> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034001737 endingPage "914" @default.
- W2034001737 startingPage "907" @default.
- W2034001737 abstract "A new approach to the synthesis of 1 (DS003, BMS-599793), a small-molecule HIV entry inhibitor, is described. The initial medical chemistry route has been modified by rearranging the sequence of synthetic steps followed by replacement of the Suzuki coupling step by the Negishi conditions. Acylation of the resulting azaindole 7 under the Friedel–Crafts conditions is studied using monoesters of chlorooxalic acid in the presence of aluminum chloride. Polymorphism of 1 is also investigated to develop conditions suitable for preparation of the desired Form 1 of the target compound. The new route is further optimized and scaled up to establish a new process that is applied to the synthesis of kilogram quantites of the target active pharmaceutical ingredient." @default.
- W2034001737 created "2016-06-24" @default.
- W2034001737 creator A5013574354 @default.
- W2034001737 creator A5021461979 @default.
- W2034001737 creator A5031956134 @default.
- W2034001737 creator A5036011375 @default.
- W2034001737 creator A5045983964 @default.
- W2034001737 creator A5049481641 @default.
- W2034001737 creator A5074826873 @default.
- W2034001737 creator A5084347124 @default.
- W2034001737 date "2013-06-11" @default.
- W2034001737 modified "2023-10-10" @default.
- W2034001737 title "Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale" @default.
- W2034001737 cites W1971057735 @default.
- W2034001737 cites W1978890358 @default.
- W2034001737 cites W1996024432 @default.
- W2034001737 cites W2031522946 @default.
- W2034001737 cites W2061343703 @default.
- W2034001737 cites W2069224810 @default.
- W2034001737 cites W2072609569 @default.
- W2034001737 cites W2079627885 @default.
- W2034001737 cites W2130882232 @default.
- W2034001737 cites W2153663490 @default.
- W2034001737 cites W2951549983 @default.
- W2034001737 cites W4243732566 @default.
- W2034001737 doi "https://doi.org/10.1021/op400012p" @default.
- W2034001737 hasPublicationYear "2013" @default.
- W2034001737 type Work @default.
- W2034001737 sameAs 2034001737 @default.
- W2034001737 citedByCount "16" @default.
- W2034001737 countsByYear W20340017372015 @default.
- W2034001737 countsByYear W20340017372016 @default.
- W2034001737 countsByYear W20340017372017 @default.
- W2034001737 countsByYear W20340017372018 @default.
- W2034001737 countsByYear W20340017372019 @default.
- W2034001737 countsByYear W20340017372020 @default.
- W2034001737 countsByYear W20340017372021 @default.
- W2034001737 countsByYear W20340017372022 @default.
- W2034001737 countsByYear W20340017372023 @default.
- W2034001737 crossrefType "journal-article" @default.
- W2034001737 hasAuthorship W2034001737A5013574354 @default.
- W2034001737 hasAuthorship W2034001737A5021461979 @default.
- W2034001737 hasAuthorship W2034001737A5031956134 @default.
- W2034001737 hasAuthorship W2034001737A5036011375 @default.
- W2034001737 hasAuthorship W2034001737A5045983964 @default.
- W2034001737 hasAuthorship W2034001737A5049481641 @default.
- W2034001737 hasAuthorship W2034001737A5074826873 @default.
- W2034001737 hasAuthorship W2034001737A5084347124 @default.
- W2034001737 hasConcept C161790260 @default.
- W2034001737 hasConcept C178790620 @default.
- W2034001737 hasConcept C185592680 @default.
- W2034001737 hasConcept C193557335 @default.
- W2034001737 hasConcept C202224193 @default.
- W2034001737 hasConcept C21951064 @default.
- W2034001737 hasConcept C71866858 @default.
- W2034001737 hasConceptScore W2034001737C161790260 @default.
- W2034001737 hasConceptScore W2034001737C178790620 @default.
- W2034001737 hasConceptScore W2034001737C185592680 @default.
- W2034001737 hasConceptScore W2034001737C193557335 @default.
- W2034001737 hasConceptScore W2034001737C202224193 @default.
- W2034001737 hasConceptScore W2034001737C21951064 @default.
- W2034001737 hasConceptScore W2034001737C71866858 @default.
- W2034001737 hasIssue "6" @default.
- W2034001737 hasLocation W20340017371 @default.
- W2034001737 hasOpenAccess W2034001737 @default.
- W2034001737 hasPrimaryLocation W20340017371 @default.
- W2034001737 hasRelatedWork W1579587594 @default.
- W2034001737 hasRelatedWork W2027222228 @default.
- W2034001737 hasRelatedWork W2132213465 @default.
- W2034001737 hasRelatedWork W2330642802 @default.
- W2034001737 hasRelatedWork W2337804912 @default.
- W2034001737 hasRelatedWork W2373491783 @default.
- W2034001737 hasRelatedWork W2949937524 @default.
- W2034001737 hasRelatedWork W2950127649 @default.
- W2034001737 hasRelatedWork W2950188360 @default.
- W2034001737 hasRelatedWork W4322758452 @default.
- W2034001737 hasVolume "17" @default.
- W2034001737 isParatext "false" @default.
- W2034001737 isRetracted "false" @default.
- W2034001737 magId "2034001737" @default.
- W2034001737 workType "article" @default.