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• W2034002331 abstract "La enfermedad celíaca (EC) se ha asociado con hígado graso no alcohólico (HGNA) y hepatopatías crónicas, como cirrosis biliar primaria (CBP), hepatitis autoinmune (HAI) y colangitis esclerosante primaria (CEP). Estudiar la frecuencia de marcadores serólogicos de EC en pacientes con las hepatopatías mencionadas y su correlación con la biopsia duodenal. En pacientes con HGNA, CBP, HAI y CEP, se estudiaron los anticuerpos IgA antiendomisio (AE) por inmunofluorescencia indirecta, IgA-IgG antigliadina (AG) y anticuerpos antitransglutaminasa tisular humano (h-ATG) mediante ELISA. En los casos positivos para al menos un marcador, se realizó una biopsia duodenal. Nueve de 101 pacientes tuvieron marcadores positivos de EC (8,9%): 7 de ellos sólo h-ATG, uno con AE y AG, y uno con los tres marcadores. Los casos positivos fueron 3/38 (7,9%) en HGNA, 3/44 (6,8%) en CBP, 2/16 (12,5%) en HAI y 1/3 en CEP. Cuatro casos con h-ATG positivos tuvieron títulos bajos (20-30 U; valores normales < 20 U) y 4 títulos altos (> 30 U). Se realizó una endoscopia con biopsia duodenal en 8 de ellos, que fue normal en 7 y compatible con EC en etapa I de Marsh en un paciente con HGNA, AG y AE positivos. El caso del único paciente con los tres marcadores positivos no se estudió por fallecer contemporáneamente. Ninguno de ellos tenía clínica sugerente de EC. La frecuencia del marcador serológico h-ATG de EC es significativa en las hepatopatías descritas. Sin embargo, debe confirmarse con biopsia duodenal, dada las elevadas tasas de histología normal en nuestro estudio. Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases (CLD), such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). AIM: To study the frequency of serological markers of CD in patients with NAFLD and CLD and their correlation with duodenal biopsy. In patients with NAFLD, PBC, AIH and PSC, we studied anti-endomysium (AE) IgA by indirect immunofluorescence and anti-gliadin IgA-IgG (AG) and human anti-tissue transglutaminase (tTG) IgA antibodies by an ELISA technique. Patients with positive serology for at least one marker underwent endoscopy with duodenal biopsies. Positive CD markers were found in 9 of 101 patients (8.9%): 7 patients were positive for tTG alone, 1 for AE and AG, and 1 patient for 3 antibodies. Positivity was as follows: 3/38 (7.9%) in NAFLD, 3/44 (6.8%) in PBC, 2/16 (12.5%) in AIH and 1/3 in PSC. Endoscopy was performed in 8 patients, with normal duodenal biopsy in 7 and 1 patient with Marsh stage 1 CD with NAFLD, positive AE and AG. The only patient with 3 positive markers died during the study without undergoing endoscopy. None of the patients had symptoms suggestive of CD. A high prevalence of positive tTG was found in patients with CLD and NAFLD. However, duodenal biopsy should be performed in these patients, given that the results of this procedure were normal in most patients in this study." @default.
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• W2034002331 title "Estudio de enfermedad celíaca en pacientes con enfermedad por hígado graso no alcohólico y con hepatopatías autoinmunes" @default.
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• W2034002331 doi "https://doi.org/10.1157/13114565" @default.
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