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- W2034002522 abstract "Merck, a respected pharmaceutical ally in our fight against pain, recently announced their voluntary removal of rofecoxib (Vioxx) from the international market because of significantly increased rates of cardiovascular disease in patients taking the drug for more than 18 months. This COX 2 anti-inflammatory has an important place in our pharmacological armamentarium for chronic pain and acute pain. One of its rapidly growing uses is in pre-emptive analgesia prior to surgery, where it has demonstrated considerable benefit in reducing the opioid analgesic doses needed to control post-operative pain. The promise of this effect for the health care system included more rapid recovery from surgery and fewer complications of higher doses of opioids such as sedation and respiratory depression, leading to shorter hospital stays. Rather than placing warning labels about the risks of extended use, Merck opted to pull the drug completely. One might say that this does not matter—there are plenty of other COX 2 Inhibitors available on the market. However, those of us who spend our days seeing dozens …" @default.
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- W2034002522 date "2004-12-01" @default.
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- W2034002522 title "Balancing Risks and Benefits in Pain Medicine: Wither Vioxx" @default.
- W2034002522 doi "https://doi.org/10.1111/j.1526-4637.2004.04056.x" @default.
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