FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034003661> ?p ?o ?g. }

• W2034003661 endingPage "2381" @default.
• W2034003661 startingPage "2375" @default.
• W2034003661 abstract "Mucosally administered antigens are often poorly immunogenic due to the difficulty of transporting antigens through the mucosal epithelium. We investigated a new route of intranasal-associated lymphoid tissue (intra-NALT) administration of antigens to circumvent the antigen transportation barrier. A comparative study was carried out on mice administered with killed whole cells of Moraxella catarrhalis strain 25238 plus cholera toxin (CT) by intra-NALT injection and nasal inoculation. Both routes induced significant elevations of several isotype antibodies against strain 25238 in saliva, lung lavage, and serum as measured by an enzyme-linked immunosorbent assay (ELISA). Most of these antibodies were paralleled by the numbers of their corresponding antibody forming cells in mucosal or systemic lymphoid tissues. However, intra-NALT injection elicited higher levels of immunoglobulin (Ig) A and IgG in saliva, IgA and IgG in lung lavage, and IgG and IgM in sera than nasal inoculation (P<or=0.05). In addition, both routes generated significant reductions of bacteria in lungs following an aerosol challenge with strain 25238 in a mouse model of pulmonary clearance. Once again, intra-NALT route showed better bacterial clearance in mouse lungs than nasal inoculation (P<0.01). These results demonstrate that intra-NALT administration of antigens is a convenient and effective route for mucosal immunization that elicits improved mucosal and systemic immunity. This new route can be used as a model to study mucosal antigens or vaccine candidates for antigen activation and interaction with the NALT that is one of major inductive sites for common mucosal immune system." @default.
• W2034003661 created "2016-06-24" @default.
• W2034003661 creator A5038319487 @default.
• W2034003661 creator A5062388610 @default.
• W2034003661 creator A5065621593 @default.
• W2034003661 creator A5077483649 @default.
• W2034003661 date "2002-05-01" @default.
• W2034003661 modified "2023-10-14" @default.
• W2034003661 title "A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model" @default.
• W2034003661 cites W1528520360 @default.
• W2034003661 cites W1594804329 @default.
• W2034003661 cites W1884708982 @default.
• W2034003661 cites W1916435595 @default.
• W2034003661 cites W1940283378 @default.
• W2034003661 cites W1964005878 @default.
• W2034003661 cites W1975826225 @default.
• W2034003661 cites W1977388584 @default.
• W2034003661 cites W1994988080 @default.
• W2034003661 cites W2005741947 @default.
• W2034003661 cites W2015066951 @default.
• W2034003661 cites W2020178528 @default.
• W2034003661 cites W2043965523 @default.
• W2034003661 cites W2052509225 @default.
• W2034003661 cites W2067331389 @default.
• W2034003661 cites W2071536249 @default.
• W2034003661 cites W2104216391 @default.
• W2034003661 cites W2105252692 @default.
• W2034003661 cites W2105941724 @default.
• W2034003661 cites W2107068916 @default.
• W2034003661 cites W2108788329 @default.
• W2034003661 cites W2112795143 @default.
• W2034003661 cites W2116974603 @default.
• W2034003661 cites W2131505205 @default.
• W2034003661 cites W2142890591 @default.
• W2034003661 cites W2147699573 @default.
• W2034003661 cites W2152307233 @default.
• W2034003661 cites W2152759128 @default.
• W2034003661 cites W2163204755 @default.
• W2034003661 cites W2164411621 @default.
• W2034003661 cites W2167933104 @default.
• W2034003661 cites W4300999069 @default.
• W2034003661 doi "https://doi.org/10.1016/s0264-410x(02)00097-x" @default.
• W2034003661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12009294" @default.
• W2034003661 hasPublicationYear "2002" @default.
• W2034003661 type Work @default.
• W2034003661 sameAs 2034003661 @default.
• W2034003661 citedByCount "30" @default.
• W2034003661 countsByYear W20340036612012 @default.
• W2034003661 countsByYear W20340036612013 @default.
• W2034003661 countsByYear W20340036612017 @default.
• W2034003661 countsByYear W20340036612022 @default.
• W2034003661 crossrefType "journal-article" @default.
• W2034003661 hasAuthorship W2034003661A5038319487 @default.
• W2034003661 hasAuthorship W2034003661A5062388610 @default.
• W2034003661 hasAuthorship W2034003661A5065621593 @default.
• W2034003661 hasAuthorship W2034003661A5077483649 @default.
• W2034003661 hasConcept C147483822 @default.
• W2034003661 hasConcept C159654299 @default.
• W2034003661 hasConcept C181152851 @default.
• W2034003661 hasConcept C203014093 @default.
• W2034003661 hasConcept C2776551000 @default.
• W2034003661 hasConcept C2776925733 @default.
• W2034003661 hasConcept C2779102806 @default.
• W2034003661 hasConcept C2780898057 @default.
• W2034003661 hasConcept C501593827 @default.
• W2034003661 hasConcept C85663871 @default.
• W2034003661 hasConcept C86803240 @default.
• W2034003661 hasConcept C8891405 @default.
• W2034003661 hasConcept C89423630 @default.
• W2034003661 hasConceptScore W2034003661C147483822 @default.
• W2034003661 hasConceptScore W2034003661C159654299 @default.
• W2034003661 hasConceptScore W2034003661C181152851 @default.
• W2034003661 hasConceptScore W2034003661C203014093 @default.
• W2034003661 hasConceptScore W2034003661C2776551000 @default.
• W2034003661 hasConceptScore W2034003661C2776925733 @default.
• W2034003661 hasConceptScore W2034003661C2779102806 @default.
• W2034003661 hasConceptScore W2034003661C2780898057 @default.
• W2034003661 hasConceptScore W2034003661C501593827 @default.
• W2034003661 hasConceptScore W2034003661C85663871 @default.
• W2034003661 hasConceptScore W2034003661C86803240 @default.
• W2034003661 hasConceptScore W2034003661C8891405 @default.
• W2034003661 hasConceptScore W2034003661C89423630 @default.
• W2034003661 hasIssue "17-18" @default.
• W2034003661 hasLocation W20340036611 @default.
• W2034003661 hasLocation W20340036612 @default.
• W2034003661 hasOpenAccess W2034003661 @default.
• W2034003661 hasPrimaryLocation W20340036611 @default.
• W2034003661 hasRelatedWork W164700985 @default.
• W2034003661 hasRelatedWork W1814470721 @default.
• W2034003661 hasRelatedWork W2078748389 @default.
• W2034003661 hasRelatedWork W2145781638 @default.
• W2034003661 hasRelatedWork W2206000012 @default.
• W2034003661 hasRelatedWork W2401779655 @default.
• W2034003661 hasRelatedWork W2416575227 @default.
• W2034003661 hasRelatedWork W2464262634 @default.
• W2034003661 hasRelatedWork W2991296003 @default.
• W2034003661 hasRelatedWork W4244345790 @default.
• W2034003661 hasVolume "20" @default.

• next