FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034003825> ?p ?o ?g. }

• W2034003825 endingPage "1207" @default.
• W2034003825 startingPage "1197" @default.
• W2034003825 abstract "Mouse and human natural killer T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, including self iGb3 and microbial alpha-glycuronosylceramides. The importance of the canonical Valpha14-Jalpha18 TCR alpha chain for antigen recognition by NKT cells is well recognized, but the mechanisms underlying the Vbeta8, Vbeta7, and Vbeta2 bias in mouse have not been explored. To study the influences of thymic selection and the constraints of pairing with Valpha14-Jalpha18, we have created a population of mature T cells expressing Valpha14-Jalpha18 TCR alpha chain in CD1d-deficient mice and studied its recognition properties in vitro and in vivo. Transgenic cells expressed a diverse Vbeta repertoire but their recognition of endogenous ligands and synthetic iGb3 was restricted to the same biased Vbeta repertoire as expressed in natural NKT cells. In contrast, alpha-GalCer, a synthetic homologue of microbial alpha-glycuronosylceramides, was recognized by a broader set of Vbeta chains, including the biased NKT set but also Vbeta6, Vbeta9, Vbeta10, and Vbeta14. These surprising findings demonstrate that, whereas Vbeta8, Vbeta7, and Vbeta2 represent the optimal solution for recognition of endogenous ligand, many Vbeta chains that are potentially useful for the recognition of foreign lipids fail to be selected in the NKT cell repertoire." @default.
• W2034003825 created "2016-06-24" @default.
• W2034003825 creator A5000757144 @default.
• W2034003825 creator A5007598672 @default.
• W2034003825 creator A5023002972 @default.
• W2034003825 creator A5046086498 @default.
• W2034003825 creator A5060376799 @default.
• W2034003825 date "2006-05-01" @default.
• W2034003825 modified "2023-09-23" @default.
• W2034003825 title "Mechanisms imposing the Vβ bias of Vα14 natural killer T cells and consequences for microbial glycolipid recognition" @default.
• W2034003825 cites W1538172952 @default.
• W2034003825 cites W1891618442 @default.
• W2034003825 cites W1953558998 @default.
• W2034003825 cites W1976710853 @default.
• W2034003825 cites W1992344128 @default.
• W2034003825 cites W1992919103 @default.
• W2034003825 cites W1994183260 @default.
• W2034003825 cites W2007394628 @default.
• W2034003825 cites W2010598169 @default.
• W2034003825 cites W2015194963 @default.
• W2034003825 cites W2016462697 @default.
• W2034003825 cites W2021106791 @default.
• W2034003825 cites W2024251508 @default.
• W2034003825 cites W2032474818 @default.
• W2034003825 cites W2065980555 @default.
• W2034003825 cites W2069556438 @default.
• W2034003825 cites W2079683161 @default.
• W2034003825 cites W2098405100 @default.
• W2034003825 cites W2099465341 @default.
• W2034003825 cites W2110711445 @default.
• W2034003825 cites W2115339386 @default.
• W2034003825 cites W2121095247 @default.
• W2034003825 cites W2121895986 @default.
• W2034003825 cites W2126068224 @default.
• W2034003825 cites W2127046119 @default.
• W2034003825 cites W2132427916 @default.
• W2034003825 cites W2134342349 @default.
• W2034003825 cites W2134377582 @default.
• W2034003825 cites W2139364837 @default.
• W2034003825 cites W2139710737 @default.
• W2034003825 cites W2142256483 @default.
• W2034003825 cites W2150454876 @default.
• W2034003825 cites W2151164793 @default.
• W2034003825 cites W2160069839 @default.
• W2034003825 cites W2160617431 @default.
• W2034003825 cites W4313347807 @default.
• W2034003825 doi "https://doi.org/10.1084/jem.20060418" @default.
• W2034003825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2121203" @default.
• W2034003825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16651387" @default.
• W2034003825 hasPublicationYear "2006" @default.
• W2034003825 type Work @default.
• W2034003825 sameAs 2034003825 @default.
• W2034003825 citedByCount "96" @default.
• W2034003825 countsByYear W20340038252012 @default.
• W2034003825 countsByYear W20340038252013 @default.
• W2034003825 countsByYear W20340038252014 @default.
• W2034003825 countsByYear W20340038252015 @default.
• W2034003825 countsByYear W20340038252016 @default.
• W2034003825 countsByYear W20340038252017 @default.
• W2034003825 countsByYear W20340038252018 @default.
• W2034003825 countsByYear W20340038252019 @default.
• W2034003825 countsByYear W20340038252020 @default.
• W2034003825 countsByYear W20340038252021 @default.
• W2034003825 crossrefType "journal-article" @default.
• W2034003825 hasAuthorship W2034003825A5000757144 @default.
• W2034003825 hasAuthorship W2034003825A5007598672 @default.
• W2034003825 hasAuthorship W2034003825A5023002972 @default.
• W2034003825 hasAuthorship W2034003825A5046086498 @default.
• W2034003825 hasAuthorship W2034003825A5060376799 @default.
• W2034003825 hasBestOaLocation W20340038251 @default.
• W2034003825 hasConcept C139563560 @default.
• W2034003825 hasConcept C147483822 @default.
• W2034003825 hasConcept C167672396 @default.
• W2034003825 hasConcept C19317047 @default.
• W2034003825 hasConcept C203014093 @default.
• W2034003825 hasConcept C22222904 @default.
• W2034003825 hasConcept C2776090121 @default.
• W2034003825 hasConcept C2778607024 @default.
• W2034003825 hasConcept C86803240 @default.
• W2034003825 hasConcept C8891405 @default.
• W2034003825 hasConcept C95444343 @default.
• W2034003825 hasConceptScore W2034003825C139563560 @default.
• W2034003825 hasConceptScore W2034003825C147483822 @default.
• W2034003825 hasConceptScore W2034003825C167672396 @default.
• W2034003825 hasConceptScore W2034003825C19317047 @default.
• W2034003825 hasConceptScore W2034003825C203014093 @default.
• W2034003825 hasConceptScore W2034003825C22222904 @default.
• W2034003825 hasConceptScore W2034003825C2776090121 @default.
• W2034003825 hasConceptScore W2034003825C2778607024 @default.
• W2034003825 hasConceptScore W2034003825C86803240 @default.
• W2034003825 hasConceptScore W2034003825C8891405 @default.
• W2034003825 hasConceptScore W2034003825C95444343 @default.
• W2034003825 hasIssue "5" @default.
• W2034003825 hasLocation W20340038251 @default.
• W2034003825 hasLocation W20340038252 @default.
• W2034003825 hasLocation W20340038253 @default.
• W2034003825 hasLocation W20340038254 @default.
• W2034003825 hasOpenAccess W2034003825 @default.

• next