Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034003932> ?p ?o ?g. }
- W2034003932 endingPage "2812" @default.
- W2034003932 startingPage "2806" @default.
- W2034003932 abstract "Breast cancer accounts for approximately 30% of all new cancer cases each year, with an annual incidence of approximately 200,000. Additionally, almost 25% of breast cancers are noted to overexpress Her2, which is an epidermal growth factor receptor. Overexpression of Her2 has been associated with a more aggressive phenotype with decreased survival. Trastuzumab, a recombinant monoclonal antibody against the Her2 receptor, is the only FDA-approved targeted agent for treatment of Her2-overexpressing breast cancer. However, despite the great success achieved with trastuzumab, many women will either not respond or eventually progress despite trastuzumab treatment. As a result, significant efforts have been applied to finding other therapies besides trastuzumab for the treatment of Her2-positive breast cancer. Work has been directed at trying to elucidate the exact mechanism of resistance to trastuzumab and identifying ways to overcome them, at increasing the efficacy of trastuzumab by combining it with other therapeutic agents and at investigating other novel agents." @default.
- W2034003932 created "2016-06-24" @default.
- W2034003932 creator A5071666554 @default.
- W2034003932 creator A5087724207 @default.
- W2034003932 date "2008-12-01" @default.
- W2034003932 modified "2023-09-30" @default.
- W2034003932 title "Her2-positive breast cancer: Herceptin and beyond" @default.
- W2034003932 cites W1599285204 @default.
- W2034003932 cites W1644299043 @default.
- W2034003932 cites W1963592300 @default.
- W2034003932 cites W1967226516 @default.
- W2034003932 cites W1988104771 @default.
- W2034003932 cites W1988289423 @default.
- W2034003932 cites W1992234802 @default.
- W2034003932 cites W1993144843 @default.
- W2034003932 cites W1996920020 @default.
- W2034003932 cites W2001447115 @default.
- W2034003932 cites W2009218955 @default.
- W2034003932 cites W2014457594 @default.
- W2034003932 cites W2030754505 @default.
- W2034003932 cites W2034801324 @default.
- W2034003932 cites W2035484878 @default.
- W2034003932 cites W2040142253 @default.
- W2034003932 cites W2059411043 @default.
- W2034003932 cites W2063249691 @default.
- W2034003932 cites W2065725840 @default.
- W2034003932 cites W2068449976 @default.
- W2034003932 cites W2073385822 @default.
- W2034003932 cites W2087186976 @default.
- W2034003932 cites W2091733153 @default.
- W2034003932 cites W2092384484 @default.
- W2034003932 cites W2092796888 @default.
- W2034003932 cites W2095342969 @default.
- W2034003932 cites W2095879193 @default.
- W2034003932 cites W2097964229 @default.
- W2034003932 cites W2099545363 @default.
- W2034003932 cites W2100375606 @default.
- W2034003932 cites W2105196235 @default.
- W2034003932 cites W2109193695 @default.
- W2034003932 cites W2110444464 @default.
- W2034003932 cites W2112893608 @default.
- W2034003932 cites W2115759102 @default.
- W2034003932 cites W2120946253 @default.
- W2034003932 cites W2121117803 @default.
- W2034003932 cites W2121620150 @default.
- W2034003932 cites W2126620646 @default.
- W2034003932 cites W2126831997 @default.
- W2034003932 cites W2130900820 @default.
- W2034003932 cites W2135535356 @default.
- W2034003932 cites W2139135964 @default.
- W2034003932 cites W2142506125 @default.
- W2034003932 cites W2144124503 @default.
- W2034003932 cites W2146384083 @default.
- W2034003932 cites W2146406055 @default.
- W2034003932 cites W2149908785 @default.
- W2034003932 cites W2154100643 @default.
- W2034003932 cites W2159459001 @default.
- W2034003932 cites W2160329331 @default.
- W2034003932 cites W2167766783 @default.
- W2034003932 cites W2168111658 @default.
- W2034003932 cites W2172265576 @default.
- W2034003932 cites W2222638000 @default.
- W2034003932 cites W2318605753 @default.
- W2034003932 doi "https://doi.org/10.1016/j.ejca.2008.09.013" @default.
- W2034003932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19022660" @default.
- W2034003932 hasPublicationYear "2008" @default.
- W2034003932 type Work @default.
- W2034003932 sameAs 2034003932 @default.
- W2034003932 citedByCount "171" @default.
- W2034003932 countsByYear W20340039322012 @default.
- W2034003932 countsByYear W20340039322013 @default.
- W2034003932 countsByYear W20340039322014 @default.
- W2034003932 countsByYear W20340039322015 @default.
- W2034003932 countsByYear W20340039322016 @default.
- W2034003932 countsByYear W20340039322017 @default.
- W2034003932 countsByYear W20340039322018 @default.
- W2034003932 countsByYear W20340039322019 @default.
- W2034003932 countsByYear W20340039322020 @default.
- W2034003932 countsByYear W20340039322021 @default.
- W2034003932 countsByYear W20340039322022 @default.
- W2034003932 countsByYear W20340039322023 @default.
- W2034003932 crossrefType "journal-article" @default.
- W2034003932 hasAuthorship W2034003932A5071666554 @default.
- W2034003932 hasAuthorship W2034003932A5087724207 @default.
- W2034003932 hasConcept C121608353 @default.
- W2034003932 hasConcept C126322002 @default.
- W2034003932 hasConcept C143998085 @default.
- W2034003932 hasConcept C159654299 @default.
- W2034003932 hasConcept C203014093 @default.
- W2034003932 hasConcept C2779786085 @default.
- W2034003932 hasConcept C2781230642 @default.
- W2034003932 hasConcept C2908728163 @default.
- W2034003932 hasConcept C530470458 @default.
- W2034003932 hasConcept C542903549 @default.
- W2034003932 hasConcept C71924100 @default.
- W2034003932 hasConceptScore W2034003932C121608353 @default.
- W2034003932 hasConceptScore W2034003932C126322002 @default.
- W2034003932 hasConceptScore W2034003932C143998085 @default.