FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034005051> ?p ?o ?g. }

• W2034005051 endingPage "102" @default.
• W2034005051 startingPage "99" @default.
• W2034005051 abstract "In a drug discrimination paradigm, the 5-HT2A/2C receptor antagonists, ritanserin, ICI 169,369 (2-(2-dimethylaminoethylthio-3-phenylquinoline hydrochloride) and mianserin, and the preferential 5-HT2A receptor antagonist, ketanserin, antagonised the discriminative stimulus effects of the 5-HT2A/2C receptor agonist, DOI ((2,5-dimethoxy-4-iodohenyl)-2-aminopropan) (0.63 mg/kg i.p.). Effective dose50 (ED50) values were: 0.32, 0.39, 0.15 and 0.03 mg/kg s.c., respectively. While the novel, selective 5-HT2C receptor antagonist, SB 200,646 (N-(1-methyl-5-iodolyl)-N′-(3-pyridyl) urea hydrochloride) was inactive (10 mg/kg s.c. and 20 mg/kg p.o.), the highly selective 5-HT2A receptor antagonist, MDL 100,907 (R-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4- fluorophenylethyl]-4-piperidine-methanol) very potently (ED50 = 0.0006) abolished the action of DOI. MDL 100,907 may display antipsychotic properties and the ‘atypical’ antipsychotics, clozapine, risperidone and sertindole, each of which possesses marked affinity at 5-HT2A receptors, abolished the discriminative stimulus effects of DOI (ED50 values of 0.07, 0.03 and 0.33 mg/kg, respectively). In contrast, haloperidol (0.16) was ineffective. These data demonstrate that 5-HT2A receptors mediate the discriminative stimulus effects of DOI and support the hypothesis that an antagonistic action at 5-HT2A receptors contributes to the in vivo actions of ‘atypical’ antipsychotics." @default.
• W2034005051 created "2016-06-24" @default.
• W2034005051 creator A5041494494 @default.
• W2034005051 creator A5058418331 @default.
• W2034005051 creator A5090546204 @default.
• W2034005051 date "1994-10-01" @default.
• W2034005051 modified "2023-10-16" @default.
• W2034005051 title "Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the ‘atypical’ antipsychotics, clozapine and risperidone" @default.
• W2034005051 cites W1964936180 @default.
• W2034005051 cites W1990975960 @default.
• W2034005051 cites W2001850627 @default.
• W2034005051 cites W2012698769 @default.
• W2034005051 cites W2014776578 @default.
• W2034005051 cites W2025678690 @default.
• W2034005051 cites W2030828774 @default.
• W2034005051 cites W2032646493 @default.
• W2034005051 cites W2154371572 @default.
• W2034005051 doi "https://doi.org/10.1016/0014-2999(94)90643-2" @default.
• W2034005051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7530204" @default.
• W2034005051 hasPublicationYear "1994" @default.
• W2034005051 type Work @default.
• W2034005051 sameAs 2034005051 @default.
• W2034005051 citedByCount "119" @default.
• W2034005051 countsByYear W20340050512012 @default.
• W2034005051 countsByYear W20340050512013 @default.
• W2034005051 countsByYear W20340050512014 @default.
• W2034005051 countsByYear W20340050512015 @default.
• W2034005051 countsByYear W20340050512016 @default.
• W2034005051 countsByYear W20340050512017 @default.
• W2034005051 countsByYear W20340050512018 @default.
• W2034005051 countsByYear W20340050512019 @default.
• W2034005051 countsByYear W20340050512022 @default.
• W2034005051 countsByYear W20340050512023 @default.
• W2034005051 crossrefType "journal-article" @default.
• W2034005051 hasAuthorship W2034005051A5041494494 @default.
• W2034005051 hasAuthorship W2034005051A5058418331 @default.
• W2034005051 hasAuthorship W2034005051A5090546204 @default.
• W2034005051 hasConcept C118552586 @default.
• W2034005051 hasConcept C134018914 @default.
• W2034005051 hasConcept C170493617 @default.
• W2034005051 hasConcept C185592680 @default.
• W2034005051 hasConcept C2775864247 @default.
• W2034005051 hasConcept C2776412080 @default.
• W2034005051 hasConcept C2776885963 @default.
• W2034005051 hasConcept C2776921671 @default.
• W2034005051 hasConcept C2777450907 @default.
• W2034005051 hasConcept C2777785214 @default.
• W2034005051 hasConcept C2778122271 @default.
• W2034005051 hasConcept C2778938600 @default.
• W2034005051 hasConcept C2779917531 @default.
• W2034005051 hasConcept C2780494398 @default.
• W2034005051 hasConcept C2780777758 @default.
• W2034005051 hasConcept C2780831388 @default.
• W2034005051 hasConcept C2780948584 @default.
• W2034005051 hasConcept C513476851 @default.
• W2034005051 hasConcept C53910766 @default.
• W2034005051 hasConcept C55493867 @default.
• W2034005051 hasConcept C71924100 @default.
• W2034005051 hasConcept C98274493 @default.
• W2034005051 hasConceptScore W2034005051C118552586 @default.
• W2034005051 hasConceptScore W2034005051C134018914 @default.
• W2034005051 hasConceptScore W2034005051C170493617 @default.
• W2034005051 hasConceptScore W2034005051C185592680 @default.
• W2034005051 hasConceptScore W2034005051C2775864247 @default.
• W2034005051 hasConceptScore W2034005051C2776412080 @default.
• W2034005051 hasConceptScore W2034005051C2776885963 @default.
• W2034005051 hasConceptScore W2034005051C2776921671 @default.
• W2034005051 hasConceptScore W2034005051C2777450907 @default.
• W2034005051 hasConceptScore W2034005051C2777785214 @default.
• W2034005051 hasConceptScore W2034005051C2778122271 @default.
• W2034005051 hasConceptScore W2034005051C2778938600 @default.
• W2034005051 hasConceptScore W2034005051C2779917531 @default.
• W2034005051 hasConceptScore W2034005051C2780494398 @default.
• W2034005051 hasConceptScore W2034005051C2780777758 @default.
• W2034005051 hasConceptScore W2034005051C2780831388 @default.
• W2034005051 hasConceptScore W2034005051C2780948584 @default.
• W2034005051 hasConceptScore W2034005051C513476851 @default.
• W2034005051 hasConceptScore W2034005051C53910766 @default.
• W2034005051 hasConceptScore W2034005051C55493867 @default.
• W2034005051 hasConceptScore W2034005051C71924100 @default.
• W2034005051 hasConceptScore W2034005051C98274493 @default.
• W2034005051 hasIssue "1" @default.
• W2034005051 hasLocation W20340050511 @default.
• W2034005051 hasLocation W20340050512 @default.
• W2034005051 hasOpenAccess W2034005051 @default.
• W2034005051 hasPrimaryLocation W20340050511 @default.
• W2034005051 hasRelatedWork W1994289021 @default.
• W2034005051 hasRelatedWork W1995879637 @default.
• W2034005051 hasRelatedWork W2012184181 @default.
• W2034005051 hasRelatedWork W2016046125 @default.
• W2034005051 hasRelatedWork W2043499184 @default.
• W2034005051 hasRelatedWork W2067198564 @default.
• W2034005051 hasRelatedWork W2091512835 @default.
• W2034005051 hasRelatedWork W2092108097 @default.
• W2034005051 hasRelatedWork W2093993467 @default.
• W2034005051 hasRelatedWork W2181872958 @default.
• W2034005051 hasVolume "264" @default.
• W2034005051 isParatext "false" @default.

• next