Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034005055> ?p ?o ?g. }
- W2034005055 endingPage "5166" @default.
- W2034005055 startingPage "5157" @default.
- W2034005055 abstract "Exosomes represent a discrete population of vesicles that are secreted from various cell types to the extracellular media. Their protein and lipid composition are a consequence of sorting events at the level of the multivesicular body, a central organelle which integrates endocytic and secretory pathways. Characterization of exosomes from different biological samples has shown the presence of common as well as cell-type specific proteins. Remarkably, the protein content of the exosomes is modified upon pathological or stress conditions. Hepatocytes play a central role in the body response to stress metabolizing potentially harmful endogenous substances as well as xenobiotics. In the present study, we described and characterized for the first time exosome secretion in nontumoral hepatocytes, and with the use of a systematic proteomic approach, we establish the first extensive proteome of a hepatocyte-derived exosome population which should be useful in furthering our understanding of the hepatic function and in the identification of components that may serve as biomarkers for hepatic alterations. Our analysis identifies a significant number of proteins previously described among exosomes derived from others cell types as well as proteins involved in metabolizing lipoproteins, endogenous compounds and xenobiotics, not previously described in exosomes. Furthermore, we demonstrated that exosomal membrane proteins can constitute an interesting tool to express nonexosomal proteins into exosomes with therapeutic purposes." @default.
- W2034005055 created "2016-06-24" @default.
- W2034005055 creator A5011586488 @default.
- W2034005055 creator A5013928900 @default.
- W2034005055 creator A5020455290 @default.
- W2034005055 creator A5021757579 @default.
- W2034005055 creator A5042331837 @default.
- W2034005055 creator A5054735287 @default.
- W2034005055 creator A5059654999 @default.
- W2034005055 creator A5060374963 @default.
- W2034005055 creator A5062732763 @default.
- W2034005055 creator A5082486218 @default.
- W2034005055 date "2008-11-11" @default.
- W2034005055 modified "2023-10-02" @default.
- W2034005055 title "Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes" @default.
- W2034005055 cites W1494035906 @default.
- W2034005055 cites W1524589668 @default.
- W2034005055 cites W1571387405 @default.
- W2034005055 cites W1600015917 @default.
- W2034005055 cites W1762620449 @default.
- W2034005055 cites W1879810571 @default.
- W2034005055 cites W1973159101 @default.
- W2034005055 cites W1977613047 @default.
- W2034005055 cites W1979876641 @default.
- W2034005055 cites W1986353574 @default.
- W2034005055 cites W1986879755 @default.
- W2034005055 cites W1995310930 @default.
- W2034005055 cites W1997571827 @default.
- W2034005055 cites W1999232604 @default.
- W2034005055 cites W2019169633 @default.
- W2034005055 cites W2028525371 @default.
- W2034005055 cites W2033598310 @default.
- W2034005055 cites W2035091931 @default.
- W2034005055 cites W2039988386 @default.
- W2034005055 cites W2041594626 @default.
- W2034005055 cites W2046026467 @default.
- W2034005055 cites W2046620120 @default.
- W2034005055 cites W2047418972 @default.
- W2034005055 cites W2049480378 @default.
- W2034005055 cites W2052815854 @default.
- W2034005055 cites W2054637102 @default.
- W2034005055 cites W2055313665 @default.
- W2034005055 cites W2061950248 @default.
- W2034005055 cites W2062984171 @default.
- W2034005055 cites W2064569549 @default.
- W2034005055 cites W2066357496 @default.
- W2034005055 cites W2067013656 @default.
- W2034005055 cites W2072451938 @default.
- W2034005055 cites W2080338272 @default.
- W2034005055 cites W2086077027 @default.
- W2034005055 cites W2089081493 @default.
- W2034005055 cites W2089907993 @default.
- W2034005055 cites W2090175640 @default.
- W2034005055 cites W2098949645 @default.
- W2034005055 cites W2101413395 @default.
- W2034005055 cites W2103994324 @default.
- W2034005055 cites W2107486259 @default.
- W2034005055 cites W2111545764 @default.
- W2034005055 cites W2114622977 @default.
- W2034005055 cites W2119764013 @default.
- W2034005055 cites W2122369254 @default.
- W2034005055 cites W2122635106 @default.
- W2034005055 cites W2129062330 @default.
- W2034005055 cites W2129269469 @default.
- W2034005055 cites W2129935560 @default.
- W2034005055 cites W2133558220 @default.
- W2034005055 cites W2136690190 @default.
- W2034005055 cites W2139466117 @default.
- W2034005055 cites W2141003137 @default.
- W2034005055 cites W2142598717 @default.
- W2034005055 cites W2143418398 @default.
- W2034005055 cites W2145978043 @default.
- W2034005055 cites W2146996431 @default.
- W2034005055 cites W2147116051 @default.
- W2034005055 cites W2150079601 @default.
- W2034005055 cites W2155366992 @default.
- W2034005055 cites W2156281143 @default.
- W2034005055 cites W2159538229 @default.
- W2034005055 cites W2170114979 @default.
- W2034005055 cites W4246066782 @default.
- W2034005055 doi "https://doi.org/10.1021/pr8004887" @default.
- W2034005055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2696236" @default.
- W2034005055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19367702" @default.
- W2034005055 hasPublicationYear "2008" @default.
- W2034005055 type Work @default.
- W2034005055 sameAs 2034005055 @default.
- W2034005055 citedByCount "495" @default.
- W2034005055 countsByYear W20340050552012 @default.
- W2034005055 countsByYear W20340050552013 @default.
- W2034005055 countsByYear W20340050552014 @default.
- W2034005055 countsByYear W20340050552015 @default.
- W2034005055 countsByYear W20340050552016 @default.
- W2034005055 countsByYear W20340050552017 @default.
- W2034005055 countsByYear W20340050552018 @default.
- W2034005055 countsByYear W20340050552019 @default.
- W2034005055 countsByYear W20340050552020 @default.
- W2034005055 countsByYear W20340050552021 @default.
- W2034005055 countsByYear W20340050552022 @default.