FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034005730> ?p ?o ?g. }

• W2034005730 endingPage "556" @default.
• W2034005730 startingPage "549" @default.
• W2034005730 abstract "Abstract In this study, we evaluated the effect produced by lateral ventricle (intracerebroventricular, ICV) infusion of the selective angiotensin (Ang)-(1-7) antagonist, d -Ala 7 -Ang-(1-7) (A-779), in the modulation of the baroreflex control of heart rate in two-kidney, one clip renovascular hypertensive rats (2K1C) treated with the angiotensin-converting enzyme (ACE) inhibitor enalapril. Twenty days after the surgery to produce renovascular hypertension, ICV cannulas were implanted in the rats with blood pressure (BP) greater than 145 mm Hg (n=33) and in sham-operated rats (n=32). Five days later, the rats were treated with enalapril (10 mg · kg −1 · d −1 ; 6 days, in the drinking water) or vehicle (tap water). On the sixth day of treatment, direct continuous BP recording and measurement of reflex changes in heart rate elicited by phenylephrine were made in conscious rats before and at 1 hour of ICV infusion of saline (8 μL/h) or A-779 (4 μg/h). To evaluate the degree of ACE blockade produced by enalapril treatment, the pressor effect of Ang I (50 ng, IV, and 100 ng, ICV) and plasma ACE activity was determined. As expected, enalapril treatment in 2K1C produced a significant fall in BP, significant attenuation in the pressor response of Ang I (IV), and a reduction in plasma ACE activity. In addition, enalapril treatment increased the baroreflex sensitivity (0.76±0.04 versus 0.43±0.04 ms/mm Hg in 2K1C untreated rats). ICV infusion of A-779 reverted the improvement in baroreflex sensitivity produced by enalapril treatment in 2K1C (from 0.80±0.07 to 0.42±0.08 ms/mm Hg) and also attenuated the baroreflex sensitivity in untreated 2K1C (0.36±0.05 versus 0.48±0.06 ms/mm Hg) and untreated sham-operated rats (1.21±0.05 versus 0.78±0.17 ms/mm Hg). These results suggest that central endogenous Ang-(1-7) is involved at least in part in the improvement of baroreflex sensitivity observed in 2K1C after peripheral chronic ACE inhibition." @default.
• W2034005730 created "2016-06-24" @default.
• W2034005730 creator A5008125686 @default.
• W2034005730 creator A5035283922 @default.
• W2034005730 creator A5070903060 @default.
• W2034005730 creator A5087277690 @default.
• W2034005730 creator A5089147956 @default.
• W2034005730 date "1997-09-01" @default.
• W2034005730 modified "2023-10-18" @default.
• W2034005730 title "Role of Angiotensin-(1-7) in the Modulation of the Baroreflex in Renovascular Hypertensive Rats" @default.
• W2034005730 cites W1517253080 @default.
• W2034005730 cites W1971097984 @default.
• W2034005730 cites W1988453846 @default.
• W2034005730 cites W1995848440 @default.
• W2034005730 cites W2001091806 @default.
• W2034005730 cites W2021802364 @default.
• W2034005730 cites W2024086991 @default.
• W2034005730 cites W2031978210 @default.
• W2034005730 cites W2043429797 @default.
• W2034005730 cites W2058168232 @default.
• W2034005730 cites W2061138599 @default.
• W2034005730 cites W2066891092 @default.
• W2034005730 cites W2070504913 @default.
• W2034005730 cites W2076212391 @default.
• W2034005730 cites W2079577579 @default.
• W2034005730 cites W2103805194 @default.
• W2034005730 cites W2104598696 @default.
• W2034005730 cites W2146426947 @default.
• W2034005730 cites W2155369856 @default.
• W2034005730 cites W2161075936 @default.
• W2034005730 cites W2161835009 @default.
• W2034005730 cites W2184083248 @default.
• W2034005730 cites W2282722486 @default.
• W2034005730 cites W2423092490 @default.
• W2034005730 cites W2466253782 @default.
• W2034005730 doi "https://doi.org/10.1161/01.hyp.30.3.549" @default.
• W2034005730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9322980" @default.
• W2034005730 hasPublicationYear "1997" @default.
• W2034005730 type Work @default.
• W2034005730 sameAs 2034005730 @default.
• W2034005730 citedByCount "86" @default.
• W2034005730 countsByYear W20340057302012 @default.
• W2034005730 countsByYear W20340057302013 @default.
• W2034005730 countsByYear W20340057302014 @default.
• W2034005730 countsByYear W20340057302015 @default.
• W2034005730 countsByYear W20340057302016 @default.
• W2034005730 countsByYear W20340057302017 @default.
• W2034005730 countsByYear W20340057302018 @default.
• W2034005730 countsByYear W20340057302019 @default.
• W2034005730 countsByYear W20340057302020 @default.
• W2034005730 countsByYear W20340057302021 @default.
• W2034005730 countsByYear W20340057302022 @default.
• W2034005730 countsByYear W20340057302023 @default.
• W2034005730 crossrefType "journal-article" @default.
• W2034005730 hasAuthorship W2034005730A5008125686 @default.
• W2034005730 hasAuthorship W2034005730A5035283922 @default.
• W2034005730 hasAuthorship W2034005730A5070903060 @default.
• W2034005730 hasAuthorship W2034005730A5087277690 @default.
• W2034005730 hasAuthorship W2034005730A5089147956 @default.
• W2034005730 hasConcept C126322002 @default.
• W2034005730 hasConcept C134018914 @default.
• W2034005730 hasConcept C191237925 @default.
• W2034005730 hasConcept C198710026 @default.
• W2034005730 hasConcept C27016395 @default.
• W2034005730 hasConcept C2775940317 @default.
• W2034005730 hasConcept C2777952589 @default.
• W2034005730 hasConcept C2777953023 @default.
• W2034005730 hasConcept C2781243531 @default.
• W2034005730 hasConcept C2908929049 @default.
• W2034005730 hasConcept C71924100 @default.
• W2034005730 hasConcept C84393581 @default.
• W2034005730 hasConceptScore W2034005730C126322002 @default.
• W2034005730 hasConceptScore W2034005730C134018914 @default.
• W2034005730 hasConceptScore W2034005730C191237925 @default.
• W2034005730 hasConceptScore W2034005730C198710026 @default.
• W2034005730 hasConceptScore W2034005730C27016395 @default.
• W2034005730 hasConceptScore W2034005730C2775940317 @default.
• W2034005730 hasConceptScore W2034005730C2777952589 @default.
• W2034005730 hasConceptScore W2034005730C2777953023 @default.
• W2034005730 hasConceptScore W2034005730C2781243531 @default.
• W2034005730 hasConceptScore W2034005730C2908929049 @default.
• W2034005730 hasConceptScore W2034005730C71924100 @default.
• W2034005730 hasConceptScore W2034005730C84393581 @default.
• W2034005730 hasIssue "3" @default.
• W2034005730 hasLocation W20340057301 @default.
• W2034005730 hasLocation W20340057302 @default.
• W2034005730 hasOpenAccess W2034005730 @default.
• W2034005730 hasPrimaryLocation W20340057301 @default.
• W2034005730 hasRelatedWork W2016647631 @default.
• W2034005730 hasRelatedWork W2023610543 @default.
• W2034005730 hasRelatedWork W2042660006 @default.
• W2034005730 hasRelatedWork W2055757354 @default.
• W2034005730 hasRelatedWork W2108711978 @default.
• W2034005730 hasRelatedWork W2116320226 @default.
• W2034005730 hasRelatedWork W2126797993 @default.
• W2034005730 hasRelatedWork W2129609331 @default.
• W2034005730 hasRelatedWork W2147788422 @default.
• W2034005730 hasRelatedWork W3169425549 @default.

• next